Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression SystemBioengineering and Biotechnology Published on 2020-07-302022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] construction COVID-19 disease expression Genetic glycosylation patterns HEK-293T cells lack mammalian membrane protein molecular Morphological morphological feature non-infectious Pandemics Particle Particles pathogenic viruses powerful tool Protein Release Research Safe SARS-CoV-2 SARS-CoV-2 VLP SARS-CoV-2 VLPs self-assemble shown small envelope structural proteins System vaccine candidate Vero E6 cell virion Virological virus virus-like particles VLP [DOI] 10.3389/fbioe.2020.00862 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP막 단백질 ANKH는 구연산염과 ATP의 세포 내보내기를 매개하여 뼈의 기계적 성능에 중요합니다Research Article Published on 2020-07-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Affect affecting ANKH ankylosis Arthritis ATP blood vessel blood vessels bone bone matrix Brain calcification cells cellular citrate Concentration contribute Critical cultured cell cultured cells cytosol disposition ENPP1 excretion expected explain Extracellular extracellular ATP functional hands homeostasis Human hydroxyapatite in urine in vivo inhibitor joint joints membrane protein metabolite metabolomics mice muscle Mutation nucleoside nucleoside triphosphates pathway Patient phenotype phosphodiesterase plasma Prevent provide Pyrophosphatase Pyrophosphate reduced released spine thought tissues underlie undetectable Urine wild type [DOI] 10.1371/journal.pgen.1008884 PMC 바로가기 [Article Type] Research Article
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2Evolutionary Genetics Published on 2020-06-082022-10-31 Journal: Genetics and Molecular Biology [Category] COVID-19, [키워드] ACE2 ACE2 binding site Analysis catalytic domain contribute coronavirus COVID-19 Critical difference evolutionary dynamics Factors Genetic Genomic analysis hosts human populations humans identify infect infecting Infection innate immune responses inter and intra-species diversity mammal membrane protein Mortality natural selection New coronavirus orthologue pandemic of COVID-19 performed placental placental mammals polymorphism Positive selection rate of infection responsible reveal SARS-CoV-2 selected trajectory Variation virus [DOI] 10.1590/1678-4685-GMB-2020-0104 PMC 바로가기 [Article Type] Evolutionary Genetics
Virtual screening and repurposing of FDA approved drugs against COVID-19 main proteaseResearch article Published on 2020-06-012022-10-05 Journal: Life sciences [Category] SARS, 신약개발, 치료제, [키워드] 2019 New Coronavirus 2019-nCoV2019 New Coronavirus 3-C-like protease 3CLpro3-C-like protease acting addition Antiviral approved Comparisons Coronavirus disease 2019 CoV COVID COVID-19 COVID-19coronavirus disease 2019 CoVs dataset docking drug drugs EEnvelope envelope Epidemics FDA approved drug investigated knowledge material membrane protein MERS MERS CoVMiddle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome Coronavirus Mmembrane protein MPro nicotinamide NNucleocapsid nucleocapsid open reading frames ORFopen reading frames Phylogenetic phylogenetics protease provided Research resolved ribavirin Safe SARS CoV SARSSevere Acute Respiratory Syndrome CoV sequence Severe Acute Respiratory Syndrome CoV Significance Spike protein Sspike protein systemically Treatment Virtual screening virus Vitamin vitamin B12 Wuhan, China [DOI] 10.1016/j.lfs.2020.117627 [Article Type] Research article
Prediction and analysis of key protein structures of 2019-nCoVShort Communication Published on 2020-05-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] 2019-nCoV Analysis Angiotensin-converting enzyme angiotensin-converting enzyme 2 back mutation binding ability database docking result Drug screening envelope protein Frame help homology homology alignment material membrane protein molecular Multiple sequence alignment Mutation nCoV nucleocapsid protein overlap performed predict predicted prediction protease Protein Proteins Result sequence Sequence analysis significant changes in Spike protein Structural analysis Structure Virtual screening [DOI] 10.2217/fvl-2020-0020 PMC 바로가기 [Article Type] Short Communication
Codon Usage and Phenotypic Divergences of SARS-CoV-2 GenesArticle Published on 2020-04-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] accumulating acute respiratory illness acute respiratory syndrome Affect analyzed antiviral drugs antiviral therapeutics appear cause China codon codon usage Codon usage bias conserved coronavirus Coronaviruses Divergence Evolution faster FIVE Genes genes encoding high mortality rate host adaptation human host influence membrane membrane protein mutational bia Mutational bias natural selection nucleocapsid Nucleocapsid proteins nucleotide mutation occurred Orthocoronavirinae SARS-CoV-2 Spike protein Spread target Usage Vaccine virus Wuhan [DOI] 10.3390/v12050498 PMC 바로가기 [Article Type] Article
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2Research Article Published on 2020-03-272022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2-RBD amino acid transporter angiotensin-converting enzyme 2 AT1 bind binding cellular receptor chaperones complex coronavirus coronavirus disease COVID-19 domain enzyme Epidemic extracellular peptidase domain full-length human ACE2 heterodimers human ACE2 human cell in viral Infection insight interact Interaction Local membrane protein Microscopy molecular basis Neutral New coronavirus pandemic disease COVID-19 polar RBD receptor Receptor binding domain residues S protein SARS-CoV SARS-CoV-2 Science scientist spike glycoprotein Structure Trimeric spike protein [DOI] 10.1126/science.abb2762 PMC 바로가기 [Article Type] Research Article
Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) InfectivityEditorial Published on 2020-02-192022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect affected affecting cause China computational tool Coronaviral coronavirus country COVID-19 death disorder Epidemic evaluated health emergency Infection infections Infectivity intrinsic laboratory-confirmed LIGHT membrane protein MERS MERS-CoV Middle East Model New coronavirus nucleocapsid protein outbreak predisposition protein intrinsic disorder respiratory syndrome coronavirus rigidity SARS-CoV Shed shell shell disorder Spread the WHO Transmissibility Transmission Viral proteins virulence WHO World Health Organization Wuhan-2019-nCoV [DOI] 10.3390/biom10020331 PMC 바로가기 [Article Type] Editorial
Aptamer-Antibody Complementation On Multiwalled Carbon Nanotube-Gold Transduced Dielectrode Surfaces To Detect Pandemic Swine Influenza VirusArticle Published on 2019-10-252023-06-14 Journal: International journal of nanomedicine [Category] Fulltext, 신종인플루엔자, [키워드] aptasensor dielectrode sensor immunosensor influenza pandemic membrane protein [DOI] 10.2147/IJN.S219976 PMC 바로가기
Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box병원체 박스에서 플라스모디움 팔시파룸 미토콘드리아 말레이트: 퀴논 산화환원효소 억제제의 확인Article Published on 2019-06-212024-08-11 Journal: Genes [Category] 말라리아, [키워드] drug target energy metabolism Inhibitor screening membrane protein Mitochondria Plasmodium falciparum [DOI] 10.3390/genes10060471 PMC 바로가기 [Article Type] Article