The SARS-CoV-2 induced targeted amino acid profiling in patients at hospitalized and convalescent stage입원 및 회복기 환자에서 SARS-CoV-2 유도 표적 아미노산 프로파일링Metabolism Published on 2021-03-262022-09-10 Journal: Bioscience Reports [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] AAAs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids biochemical Combination complete recovery convalescent convalescent patient Convalescent patients convalescent stage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patients except for Fatty acid fatty acid oxidation fatty acids Health Health crisis Hospitalization Hospitalized hospitalized patients Infection inflammatory status Injury liver majority manifested metabolites methionine MOST Patient plasma Post-infection reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus subject subjects suggested [DOI] 10.1042/BSR20204201 PMC 바로가기 [Article Type] Metabolism
Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasmaResearch Article Published on 2021-03-052022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] active against acute respiratory syndrome antimalarial drug blood sample clinical study conditions coronavirus COVID-19 pandemic develop development Dilution emergency response ESI freeze-thaw cycles HCQ Human plasma Hydroxychloroquine injected Ion LC-MS/MS system less Liquid chromatography m/z matrix effect metabolite metabolites normalized overcome pandemic quantification quantitation ranged reported Result Sample SARS-CoV-2 selected Tandem mass spectrometry temperature Total Volume was used were used [DOI] 10.1371/journal.pone.0247356 PMC 바로가기 [Article Type] Research Article
Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection플라즈마의 확산 및 이완 편집된 양성자 NMR 분광법은 SARS-CoV-2 감염의 고충실도 초분자 바이오마커 시그니처를 보여줍니다Article Published on 2021-03-022022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 바이오마커, 진단, [키워드] age-matched control Analysis applied Biomarker carried choline classification Combination Comparator group component Concentration Control COVID-19 diagnostic diagnostics discriminant analysis elevated experiments following functional Functional assessment glycoprotein Glycoproteins healthy high-density High-density lipoprotein Hospitalized identity low-density Low-density lipoprotein Magnetic resonance spectroscopy marker metabolite metabolites molecular molecular markers negative patients NMR not significantly different nuclear nuclear magnetic resonance Patient patients phospholipid Phospholipids plasma positive Principal component principal component analysis proton Receiver operator characteristic reduced Relaxation respiratory rRT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 positive patients SARS-CoV-2 positivity selected signature significantly Spectroscopy statistical Structure Symptoms the disease was determined [DOI] 10.1021/acs.analchem.0c04952 PMC 바로가기 [Article Type] Article
Lactobacillus plantarum strain HT-W104-B1: potential bacterium isolated from Malaysian fermented foods for control of the dermatophyte Trichophyton rubrum락토바실러스 플란타룸 균주 HT-W104-B1: 말레이시아 발효식품에서 분리된 피부사상균 트리코피톤 루브럼 제어를 위한 잠재적 세균Original Paper Published on 2021-02-242024-07-28 Journal: World journal of microbiology & biotechnology [Category] 백선증, [키워드] anti-fungals Dermatophyte Lactic acid bacteria metabolites Organic acids [DOI] 10.1007/s11274-021-03020-7 PMC 바로가기 [Article Type] Original Paper
Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19약물, 대사 산물 및 폐 축적 작은 Lysosomotropic 분자: 다중 표적은 SARS-CoV-2 감염 및 COVID-19로의 진행을 방해합니다Hypothesis Published on 2021-02-112022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect approved drug approved drugs Bacterial biological characteristic candidate cathepsin cathepsin L cathepsin L-dependent characteristic Chloroquine compounds condition coronavirus coronavirus disease COVID-19 CRS cytokine Cytokine release syndrome Cytokine storm disease drug Drug repurposing drugs Effects eligibility criteria endothelial enrichment heterogeneous group host cells hydroxy Hypothesis IL-6 Inflammatory intrinsic lysosomal enzyme lysosomal enzymes lysosome Lysosomes lysosomotropism metabolite metabolites Multiple OTC pandemic Patient pharmacological profile Progress Prophylaxis pulmonary tissue pulmonary tissue accumulation receiving respiratory SARS-CoV-2 SARS-COV-2 infection second messengers severe acute respiratory syndrome Coronavirus Small molecules Stress stress response systemic inflammation targeting targets tissue transition Treatment triggered Viral viral entry viral host cell entry viral infections [DOI] 10.3390/ijms22041797 PMC 바로가기 [Article Type] Hypothesis
Covid-19 Automated Diagnosis and Risk Assessment through Metabolomics and Machine Learning대사체학 및 기계 학습을 통한 Covid-19 자동 진단 및 위험 평가Article Published on 2021-02-022022-09-11 Journal: Analytical Chemistry [Category] MERS, 바이오마커, 치료기술, [키워드] Algorithm Analysis applied approach assessment assist Biomarker Biomarkers blinded Control COVID-19 COVID-19 diagnosis cross-sectional cross-sectional study Decision-making Diagnostic method elect enrolled equation feature Government Health Healthcare professional healthcare professionals identify impairment Infection introduced machine learning Machine learning algorithms management mass spectrometry metabolite metabolites minutes outcomes pathophysiology Patient Patient management plasma sample plasma samples platform poverty Region reopening resources risk Risk assessment Risk management robustness sensitivity specificity the disease [DOI] 10.1021/acs.analchem.0c04497 PMC 바로가기 [Article Type] Article
Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolitesArticle Published on 2021-01-272022-10-04 Journal: Communications Biology [Category] 치료제, [키워드] addition ADP-ribose approaches base bind binding binding ability binding affinity binding pocket biochemical biological function Biological functions chromatin co-crystallized conditions DNA repair domain domains genomic highlight in viral investigated involved Ligand MERS-CoV metabolism metabolite metabolites Middle East nicotinamide adenine dinucleotide NMR spectroscopy observation physiological temperature provide recognize Replication Small molecules stability variety viral infection Viral proteins X-ray crystallography [DOI] 10.1038/s42003-020-01633-6 PMC 바로가기 [Article Type] Article
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19Multi-Omics는 경증과 중등도의 COVID-19 사이의 급격한 질병 상태 변화를 해결합니다Clinical Trial Published on 2020-12-102022-09-11 Journal: Cell [Category] SARS, 유전자 메커니즘, 임상, [키워드] accompanied amplify Analysis Blood blood clotting blood draw capture changes CITE-seq clinical measurements collected COVID-19 COVID-19 patient Diagnosis disease severity effective elevated feature identify immune Immune cell immune cells immune response Infection inflammatory signaling metabolic processes metabolite metabolites metabolomics Metrics Mild moderate disease multi Multi-omics phenotype plasma proteomics representing SARS-CoV-2 Secretome Sharp shift single-cell single-cell RNA-seq single-cell secretome. single-cell TCR-seq therapeutic intervention [DOI] 10.1016/j.cell.2020.10.037 PMC 바로가기 [Article Type] Clinical Trial
Novel Molecular Evidence Related to COVID-19 in Patients with Diabetes MellitusReview Published on 2020-12-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected aggravate angiotensin-converting enzyme 2 anti-inflammatory effect Asymptomatic COVID-19 Autoimmune benefit binding caused Cell cleavage clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 progression cytosolic Diabetes Mellitus Dipeptidyl peptidase-4 Effectiveness Evidence exhibit facilitate furin global pandemic glycemic control glycosylation Hospitalization human Angiotensin-converting enzyme hyperglycemia immune response induce inhibitor Injury innate immune system Innate immunity Lactate lower mortality medication metabolites Mild novel outcomes pancreatic Patient patients with diabete pro-inflammatory cytokine protective effect Randomized receptor reduction in renin–angiotensin–aldosterone system S protein SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 susceptibility targets Th1 Th2 immunity the S protein TMPRSS2 transmembrane serine protease Treatment Trigger uncontrolled vicious cycle viral entry viral genome viral S protein [DOI] 10.3390/jcm9123962 PMC 바로가기 [Article Type] Review
From Circulation to Cultivation: Plasmodium In Vivo versus In Vitroarticle Published on 2020-11-302024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] adaptation Ex vivo in vitro in vivo metabolites Plasmodium [Article Type] article