Persistent Oxidative Stress and Inflammasome Activation in CD14 high CD16 − Monocytes From COVID-19 PatientsCOVID-19 환자의 CD14 높은 CD16- 단핵구에서 지속적인 산화 스트레스 및 염증 활성화Immunology Published on 2022-01-142022-08-31 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] addition caspase caspase-1 caused CD14 CD14highCD16− monocytes CD16 Cell contribute coronavirus coronavirus disease correlated COVID-19 dependent on disease severity displaying enrichment evidenced hallmark healthy controls hyperinflammation Hyperinflammatory IL-1β immunopathology implicated in vitro Inflammasome inflammasome activation lipid peroxidation Mild mitigate mitochondrial monocyte Monocytes NLRP3 NLRP3 inflammasome outcome outcomes oxidative oxidative stress oxidative stress response pathway Patient persistent response SARS-CoV-2 secretion severe COVID-19 patient severe COVID-19 patients signaling pathway Stress stress response stress responses Superoxide therapy [DOI] 10.3389/fimmu.2021.799558 PMC 바로가기 [Article Type] Immunology
Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection감염 후 최대 15개월까지 COVID-19(PASC)의 급성 후유증에서 CD16+ 단핵구에서 SARS CoV-2 S1 단백질의 지속성Immunology Published on 2022-01-102022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, [키워드] acute infection Affect analyzed B-cell CCR5 CD14+ CD16+ COVID-19 COVID-19 pandemic COVID-19 symptom elevated flow cytometric fractalkine full length healthy control healthy controls individuals infected individuals Infection Inflammation initial investigated mass spectrometry mechanism monocyte Monocytes mononuclear cells Month non-classical monocyte Non-classical monocytes PASC Patient patients Peripheral blood Post-infection S1 protein SARS CoV-2 SARS CoV-2 S1 protein SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 S1 protein sequence severe COVID-19 patient significantly statistically significant subset T-cell the SARS-CoV-2 Treatment [DOI] 10.3389/fimmu.2021.746021 PMC 바로가기 [Article Type] Immunology
Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7Article Published on 2022-01-102022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] amplification anti-viral responses Autoimmunity cascade Cell Control Critical differentiation antigen dysregulated elicit expression gene induction human cell human monocyte IFNα IFNβ Infection innate immune innate immune response interferon response interferons interferons (IFNs IRF7 MNDA monocyte Monocytes myeloid myeloid cell nuclear pathogen Pattern recognition receptors promoter Protein recruited recruitment regulated Regulation required response RNA Polymerase II Signal transduction STAT2 transcription factor transcriptional regulation Type Type I IFN type I interferon [DOI] 10.1038/s41467-021-27701-x PMC 바로가기 [Article Type] Article
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19Research Article Published on 2022-01-102022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] abrogated Anti-inflammatory therapy anti-inflammatory treatment autocrine Bacterial Bacterial infection bacterial superinfection bacterial superinfections caused CD11b CD163 CD66b CD86 Cell cellular characterized classical Clusters complicate Course COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP CXCR1 CXCR2 CXCR4 cytokine cytokine levels cytokine signaling Dexamethasone disease severity driven by dysregulated dysregulation elevated Ex vivo exacerbate exhibited expression function functional HLA-DR host response host-response hypercytokinemia Hyperinflammatory ICU IFN-γ IL-4 IL-6 level Immune cell immune cells immune response IMPROVE increased mortality induce Inflammatory marker inflammatory mediator Inflammatory mediators innate immune function Innate immunity low expression monocyte Monocytes MPO myeloid cell NET neutrophil paracrine paralysis patients phenotype phenotypic plasma provide receiving reduced reduction reduction in reflected response ROS production SARS-CoV-2 SARS-CoV-2 pathogenesis subsequent suppressed surface receptor Symptom synergistic systemic inflammation the disease TNF-α treated utility [DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
Inflammasome activation in neutrophils of patients with severe COVID-19Research article Published on 2022-01-062022-10-05 Journal: Blood advances [Category] COVID19(2023년), SARS, 변종, [키워드] Activation acute respiratory syndrome ASC coronavirus correlation COVID-19 COVID-19 patient demonstrated engage fluorescent form human disease implicated induce Inflammasome inflammasome activation Inflammation leukocytes Macrophage mice Microscopy microtubule organizing center monocyte NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils NLRP3 inflammasome nuclear nuclei nucleus pathogenesis of COVID-19 Patient Peripheral blood positive Protein reporter Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient stimulated the cytokine storm tracheal aspirate [DOI] 10.1182/bloodadvances.2021005949 [Article Type] Research article
Monocyte distribution width as a novel sepsis indicator in COVID-19 patientsCOVID-19 환자의 새로운 패혈증 지표로서 단핵구 분포 폭Research Published on 2022-01-042022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission analyzed assigned cause caused changes in Clinical data collected coronavirus coronavirus disease correlation COVID-19 COVID-19 infection COVID-19 patient Department determine distribution Emergency emergency department evaluated four group four groups hematological identify In-vitro increased risk Indicator individual Infection laboratory parameter Laboratory parameters localized infection MDW monitoring monocyte Monocytes Novel coronavirus novel coronavirus disease on admission parameter Patient poor prognosis positive correlation predict progression provide quartile quartiles respiratory Result Retrospective analysis SARS-CoV-2 SARS-COV-2 infection Sepsis severe acute respiratory syndrome Coronavirus severity of COVID-19 supplementary material systemic infection systemic inflammation tested trauma virus window [DOI] 10.1186/s12879-021-07016-4 PMC 바로가기 [Article Type] Research
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different SeveritiesImmunology Published on 2022-01-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accompanied addition Analysis Antigen antigen processing B-cell CD14 CD69 CD83 collected Coronavirus disease 2019 COVID-19 CXCR4 dataset datasets dendritic cell dendritic cells disease severity downregulated downregulation exhibited FOS healthy controls HLA HLA class II HLA-DRA HLA-DRB1 IGHV3-21 immune Immune cell immune characteristics immune disorder Immunoglobulin JUN leukocyte memory T memory T cells monocyte mononuclear cell myeloid myeloid cells pathway Patient PBMCs performed Peripheral blood peripheral immune response plasmacytoid dendritic cell progression stage proportion recovered recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Regulation reported severe symptom single-cell Single-cell RNA sequencing symptom onset T-cell differentiation upregulated upregulation [DOI] 10.3389/fimmu.2021.781432 PMC 바로가기 [Article Type] Immunology
Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes순환 면역 세포 및 가용성 매개체의 통합 분석Research Paper Published on 2022-01-012022-09-10 Journal: Theranostics [Category] 바이오마커, [키워드] activated activating adaptive addition Analysis analyzed asymptomatic infection Blood caused CCL2 CCL8 CD8+ Cell cellular chemokine chemokines circulating clinical manifestation clinical manifestations Clinical outcome Clustering cold-like symptom cold-like symptoms complex comprehensive analysis coronavirus disease Coronavirus disease 2019 correlated COVID19 COVID19 patient COVID19 patients Critical care CXCL10 CXCL9 Cytokines deregulated disease disease course disease severity exacerbated experimental variable expressing expression Extracellular Frequency GzmA GzmB healthy donors heterogeneous Hospital admission Hospitalization Host immune response IFNα IL18 IL1RA IL2 IL31 IL36B immune immune response immune signature immunological IMPROVE Infection Inflammation Inflammatory cytokine Inflammatory cytokines Inflammatory factor LAG3 Ligand ligands MIC Mild monocyte Monocytes Multivariate analysis NK cell NK cells NKG2D organ damage Patient PD1 predict Prognosis receptor reduction respiratory respiratory tract infection Respiratory tract infections reveal risk of death SARS-CoV-2 Sepsis Severe case similarity subset TNFα ULBP utility variety [DOI] 10.7150/thno.63463 PMC 바로가기 [Article Type] Research Paper
A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface420 Published on 2021-12-282022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome age B cells Blood children Coronavirus-2 COVID-19 COVID-19 patients cross-talk Cytokine storm deviation Ebola elicit encodes epithelia epithelial epithelial cell Express Factors fraction gene cluster hallmark healthy children Immune cell immune cells immune dysregulation induce infected with SARS-CoV-2 Inflammatory inflammatory phenotype influenza A initial Interaction interferon lung manifestation monocyte multiorgan failure myeloid cell nonstructural proteins pathogenic viruses Patient Perturbation Pneumonia Protein provide provoke reported SARS-CoV-2 SARS-CoV-2 protein severe COVID-19 severe disease Significance spike systemic inflammation transcriptional transduced virus [DOI] 10.1073/pnas.2116853118 PMC 바로가기 [Article Type] 420
People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenCOVID-19에 걸린 위독한 사람들은 사망을 예측하고 SARS-CoV-2 폐 바이러스 부담을 반영하는 말초 면역 프로필을 나타냅니다Article Published on 2021-12-212022-09-12 Journal: Cell Reports Medicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis association Blood contribute COVID-19 COVID-19 outcome Critically ill CXCL10 death gene modules higher risk immune cell state Immune profile immune state Inflammatory Inflammatory cytokines inflammatory monocytes interferon signaling Lower respiratory tract lung machine learning molecular feature monocyte Mortality myeloid cell outcomes peripheral Predictive respiratory sample SARS-CoV-2 severe COVID-19 single-cell Single-cell RNA sequencing single-cell RNA-seq subsequent transcriptional profile type I interferon upregulation viral burden with COVID-19 [DOI] 10.1016/j.xcrm.2021.100476 PMC 바로가기 [Article Type] Article