What can cerebrospinal fluid testing and brain autopsies tell us about viral neuroinvasion of SARS-CoV-2뇌척수액 검사와 뇌 부검을 통해 SARS-CoV-2의 바이러스 신경 침범에 대해 알 수 있는 것Review Published on 2021-07-012022-09-11 Journal: Journal of medical virology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Autopsy autopsy study Brain Brainstem cause caused causes Central nervous system Cerebellum cerebrospinal cerebrospinal fluid cerebrum change Characteristics Clinical practice CNS complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CSF death detection rate diagnose direct infection documentation Evidence examined in some Infection limitations neuroinvasion Neuroinvasive Neurological symptom Neurological symptoms neurotropic Novel coronavirus olfactory pathological change pathophysiology Patient patients positive result primary symptom primary symptoms Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Viral viruses [DOI] 10.1002/jmv.26943 PMC 바로가기 [Article Type] Review
Chronology of COVID-19 Symptoms in Very Old Patients: Study of a Hospital OutbreakArticle Published on 2021-06-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Atypical symptoms chronic condition Cohort controls COVID-19 COVID-19 outbreak defined delirium Diagnosis diagnosis of COVID-19 distribution early diagnosis eight Fever first symptom FIVE Frequency Gastrointestinal symptom Hospitalized Inpatient IQR majority median Neurological symptom older patient older patients outbreak Patient patients positive patients proportion recorded rehabilitation respiratory symptom Symptom Symptoms symptoms of COVID-19 temporal pattern the disease typical symptom were infected [DOI] 10.3390/jcm10132962 PMC 바로가기 [Article Type] Article
The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer’s Disease PathologyCell and Developmental Biology Published on 2021-06-252022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition Altered Alzheimer’s disease Alzheimer’s disease anatomical distribution angiotensin-converting enzyme 2 Brain brain region brain regions caused cells Central nervous system contribute coronavirus coronavirus disease COVID-19 COVID-19 patient downregulated Endothelial cell expressed expression level immunohistochemistry Invasion manifestation mapped Neurological symptom nucleus pandemic pathology protein level Research SARS-CoV-2 suggested [DOI] 10.3389/fcell.2021.684874 PMC 바로가기 [Article Type] Cell and Developmental Biology
Persistent cognitive impairment associated with cerebrospinal fluid anti-SARS-CoV-2 antibodies six months after mild COVID-19Letter to the Editor Published on 2021-06-212022-10-30 Journal: Neurological Research and Practice [Category] COVID-19, [키워드] acute phase affected anti-SARS-CoV-2 antibody Central nervous system cerebrospinal fluid Cognitive impairment COVID-19 COVID-19 pandemic CSF antibodies disease Evidence female implementation increasingly individual Invasion long-lasting Mild Neurologic sequelae Neurological symptom Patient persistent SARS-CoV-2 SARS-COV-2 infection supplementary material the disease virus [DOI] 10.1186/s42466-021-00135-y PMC 바로가기 [Article Type] Letter to the Editor
nCoV-2019 infection induced neurological outcome and manifestation, linking its historical ancestor SARS-CoV and MERS-CoV: a systematic review and meta-analysisArticle Published on 2021-06-182022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 2019-nCoV addition Analysis analyzed article Case report clinical trials clinician collected correlated COVID-19 COVID-19 patient COVID-19 positive patient COVID-19 positive patients criteria cross cross-sectional cross-sectional study cumulative disease event headache help heterogeneity identify Infection lack management manifestation Manifestations mechanism MedCalc Meningitis MERS MERS-CoV Meta-analysis nCOV-2019 nervous system Neurologic impairment neurological Neurological involvement neurological manifestation neurological sign Neurological symptom NEUROLOGY observational study outcome pandemic Pandemics pathogenic Patient patients present presenting Prevalence proportion reported SARS-CoV screened searched Seizure severity Signs and symptoms Standard Symptom symptomatic systematic review was used [DOI] 10.1038/s41598-021-92188-x PMC 바로가기 [Article Type] Article
Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19Review Published on 2021-06-172022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Acute kidney injury addition adjuvant Ageusia analyzed Anosmia anti-vascular antioxidant antioxidants brain tissue cause caused cellular Central nervous system change clinical manifestation Complication contribute coronavirus 2 cough CoV infection COVID-19 death disease disorders distress drugs endothelial fatigue Fever Growth factors headache immunomodulators Infectious disease Inflammation Injury liver dysfunction modulating myalgias neuro-therapeutic management Neuroinvasive Neurological complication neurological damage neurological manifestation Neurological symptom oxidative stress respiratory SARS-CoV-2 Seizures specific treatment suggested Supportive treatment Symptom syndrome the disease Treatment Vaccine with COVID-19 [DOI] 10.3390/antiox10060971 PMC 바로가기 [Article Type] Review
Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s DiseaseNeuroscience Published on 2021-06-152022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] acute respiratory syndrome addition Brain cells Central nervous system change clearance CNS contribute coronavirus Coronavirus disease 2019 COVID-19 death delirium disease disorders Genetic globe highlight homeostatic Hyposmia immunopathology in viral include individual Infection infections Invasion lesson mechanism Meningitis MERS-CoV microglia microglial Middle East neurodegeneration Neurodegenerative diseases Neuroinvasive neurological Neurological symptom neurons neuropsychiatric disorders neurotropic outbreak pandemic Parkinson’s disease Parkinson’s disease pathogenic pathophysiology plasticity provide re-infected Reinfection Relevance respiratory syndrome coronavirus response responsible rising RNA RNA virus SARS-CoV-2 SARS-COV-2 infection stroke vasculature viral clearance viral infection viral RNA neurotropism [DOI] 10.3389/fncel.2021.670298 PMC 바로가기 [Article Type] Neuroscience
Heterogeneity in Regional Damage Detected by Neuroimaging and Neuropathological Studies in Older Adults With COVID-19: A Cognitive-Neuroscience Systematic Review to Inform the Long-Term Impact of the Virus on Neurocognitive TrajectoriesNeuroscience Published on 2021-06-032022-10-31 Journal: Frontiers in Aging Neuroscience [Category] COVID-19, [키워드] added Adults Affect Ageing behavioural Brain Cardiopulmonary Case series cellular damage cognitive consequence Consequences COVID-19 COVID-19 infection damage data-driven database develop DNA dysfunction Encephalitis Encephalopathy events Evolution exacerbated functional Health heterogeneity hospitalisation hospitalised patient identify Impact indicate Infection Inflammation involved manuscript mechanism Mental neurocognitive Neuroimaging neurological Neurological symptom Neuropathology Older older patient olfactory Other outcome output patients with COVID-19 Perspective Premature Region Regional reported review screened searched selected severe symptom stroke Support systematic review the disease virus Web of Science with COVID-19 [DOI] 10.3389/fnagi.2021.646908 PMC 바로가기 [Article Type] Neuroscience
Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of LiteratureCOVID-19 환자의 대뇌 정맥동 혈전증: 다기관 연구 및 문헌 검토Observational Study Published on 2021-06-012022-09-11 Journal: Journal of stroke and cerebrovascular diseases : t [Category] MERS, 바이오마커, 임상, [키워드] case sery cerebral cerebral venous sinus thrombosis Clinical management Clinical presentations Cohort complication of COVID-19 consciousness COVID-19 COVID-19 diagnosis COVID-19 infection COVID-19 positive patient COVID-19 symptom COVID-19 symptoms cross-sectional CVST D-dimer decreased consciousness Deep venous thrombosis develop diagnosed Diagnosis elevated evaluated event female Fever focal neurologic deficit Gastrointestinal symptom gastrointestinal symptoms headache Infection Inflammatory biomarker inflammatory biomarkers initial interquartile range laboratory data literature median time Most patient Most patients multicenter multicenter study Myocardial infarction neurologic Neurological symptom Neurological symptoms non-specific outcome Patient patients with COVID-19 positive positive patients Pulmonary embolism radiologic radiological reference range reference ranges Retrospective study review risk Risk factors SARS-CoV-2 significantly Sinus Sinus thrombosis stroke study period Symptom thrombosis venous venous sinus venous thromboembolic Venous thrombosis [DOI] 10.1016/j.jstrokecerebrovasdis.2021.105733 PMC 바로가기 [Article Type] Observational Study
Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 InfectionArticle Published on 2021-05-212022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] accompanied Brain Cerebrovascular disease change clinical picture control group correlated evaluated example FLAIR form healthy lesion manifestation Mild moderate MRI Neurological symptom Neurological symptoms New occur pandemic participant Patient Respiratory disease respiratory symptom SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severity silent subcortical subject the SARS-CoV-2 virus worsening [DOI] 10.3390/jpm11060442 PMC 바로가기 [Article Type] Article