SARS-CoV2 wild type and mutant specific humoral and T cell immunity is superior after vaccination than after natural infectionSARS-CoV2 야생형 및 돌연변이 특이 체액성 및 T 세포 면역은 자연 감염 후보다 백신 접종 후 우수Article Published on 2022-04-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding Alpha antibodies antibody Antibody titer Antibody titers B.1.617.2 Blood blood sample Blood samples CD4 CD4+ T cell cytokine production delta variant Finger prick flow cytometric flow cytometric intracellular cytokine staining humoral IFN-γ IL-2 immune response immune responses Immunity Infection intracellular cytokine staining investigated mutant natural infection neutralisation no significant difference overcome pandemic Patient peptide peptides positive RBD RBD binding Receptor binding domain reduced response responses SARS-CoV2 significant difference significantly Specific Spike protein Stimulation strain Strong subject subjects T cell T cell response T cell responses tested the vaccine TNF-α vaccinated individuals vaccination variant variants Virus neutralization was reduced were measured wild type [DOI] 10.1371/journal.pone.0266701 PMC 바로가기 [Article Type] Article
Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccineSARS-CoV-2 BNT162b2-mRNA 백신 접종 3개월 후 항체 감소에도 불구하고 스파이크 특이적 T 세포 면역 지속Article Published on 2022-04-232022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] anti-RBD Anti-RBD antibody antibody Antigen boost cell-mediated immune cell-mediated response cellular correlation Effective vaccines effort evaluated expand HCW highlight Hospitalization humoral IFN-γ IL-2 immune response Immunity neutralization neutralizing antibody peptides persistence persistent produced public health measure reduce reduction SARS-CoV-2 SARS-CoV-2 transmission second dose spike T cell T-cell Th1 cytokine TNF-α to define vaccination Vaccine was performed Whole blood worker [DOI] 10.1038/s41598-022-07741-z PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 Proteins in Wastewater Samples by Mass Spectrometry질량 분석법에 의한 폐수 샘플의 SARS-CoV-2 단백질 검출Article Published on 2022-04-192022-09-11 Journal: Environmental science & technology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Biomarker Chain Reaction collected COVID-19 COVID-19 infection COVID-19 pandemic detection eight Epidemiology feces health system host cell Infection information liquid chromatography−mass spectrometry mass mass spectrometry mass vaccination occurred outbreak peptide peptides polymerase chain polymerase chain reaction pp1ab Protein proteomics quantification Quantitative quantitative polymerase chain reaction Sample SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 RNA SARS-CoV-2 virus Spectrometry the SARS-CoV-2 virus These data transcribed Treatment unique Urine vaccination wastewater [DOI] 10.1021/acs.est.1c04705 PMC 바로가기 [Article Type] Article
Systematic profiling of antigen bias in humoral response against SARS-CoV-2SARS-CoV-2에 대한 체액 반응의 항원 편향에 대한 체계적인 프로파일링Article Published on 2022-04-152022-09-11 Journal: Virus research [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adverse events antibodies Antigen Antigen bias Asymptomatic collected epitope Epitopes evaluate humoral humoral immune response IgG and IgM IgM responses immune system Microarray Patient patients peptide peptides promote Protein Proteome microarray RBD recovered patient response S-specific antibody SARS-CoV-2 SARS-CoV-2 vaccines sera significantly symptomatic the SARS-CoV-2 [DOI] 10.1016/j.virusres.2022.198711 PMC 바로가기 [Article Type] Article
Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterialsTHz 메타물질을 이용한 SARS-CoV-2 스파이크 단백질 유래 펩타이드 검출 및 판별Article Published on 2022-04-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid analyzed component coronavirus detection diagnostic distribution domain effective examined frequencies Health hydropathy information investigated Metamaterials molecular peptide peptides Protein Quantitative analysis RBD RBD sequences Receptor-binding domain reproducibility Research residue risk SARS-CoV SARS-CoV molecular sensing SARS-CoV-2 SARS-CoV-2 spike selective sensitivity sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome family species specificity Spread structural proteins Terahertz time-domain spectroscopy. the RBD unique viral entry [DOI] 10.1016/j.bios.2022.113981 PMC 바로가기 [Article Type] Article
Advances in the Development of SARS-CoV-2 Mpro InhibitorsSARS-CoV-2 Mpro 억제제 개발의 발전Review Published on 2022-04-142022-09-11 Journal: Molecules [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] acting advance antiviral drugs carried Chemical structure Compound COVID-19 demonstrated development displaying drug effort high affinity inhibitor inhibitors Initially main protease MERS MERS-CoV MPro outbreak peptide peptides protease Proteases reactive reported SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro Scientific community sequence small molecule tested these compound these compounds virus [DOI] 10.3390/molecules27082523 PMC 바로가기 [Article Type] Review
Anurans against SARS-CoV-2: A review of the potential antiviral action of anurans cutaneous peptidesArticle Published on 2022-04-142022-10-04 Journal: Virus research [Category] COVID19(2023년), SARS, 치료제, [키워드] Abstract addition antimicrobial peptide Antiviral antiviral action Antiviral actions Antiviral effect Anuran's skin caused China Clinical sign COVID-19 disease drug effective effort etiology identify identifying Image in silico literature review natural antiviral pandemic Patient peptide peptides Pneumonia Prevent reported SARS-CoV-2 secreted Sequencing Symptom tested the SARS-CoV-2 virus therapeutic agent therapeutic agents treat Treatment triggered viral infectious diseases virus viruses World Health Organization [DOI] 10.1016/j.virusres.2022.198769 PMC 바로가기 [Article Type] Article
CHARM: COVID-19 Health Action Response for Marines-Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testCHARM: qPCR SARS-CoV-2 테스트 양성 후 무증상 및 증상 감염에 대한 항원 특이적 인터페론-감마 및 IL2 반응의 해병을 위한 COVID-19 건강 조치 대응Article Published on 2022-04-072022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] Action All participants Asymptomatic Asymptomatic cases Cell mediated immunity class correlated COVID-19 COVID-19 symptoms COVID-19 vaccine COVID-19 vaccines dropped enrolled Enrollment epitope Epitopes Follow-up frequencies Frequency IFN-γ IFN-γ response IFN-γ responses IL2 immune response include Infection membrane N and M N and S proteins N protein nucleocapsid occurred participant Participants peaked peptide peptide pool peptides positive Post-infection predicted Protein Proteins qPCR qPCR test Responder response responses S proteins S, N and M proteins SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 test significantly Study participants subjects Support symptomatic symptomatic and asymptomatic symptomatic infection symptomatic participants T cell T cell response T cell responses tested the N protein These data were measured with COVID-19 [DOI] 10.1371/journal.pone.0266691 PMC 바로가기 [Article Type] Article
Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response재조합 VLP는 천연 SARS-COV-2 단백질에서 면역원성을 나타내지 않는 RBM 펩타이드를 강화하여 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-04-012022-09-11 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Antigen antigenicity Antisera candidate carrier protein core antigen coronavirus demonstrated effective delivery elicit epitope Epitopes HBcAg immunization in vitro inactivated indicate KLH linear mice motif Multi-epitope vaccine Neutralizing activity neutralizing antibody Neutralizing antibody response New overlapping Particle peptide peptide epitope peptides Protein RBM reactivity receptor binding motif receptor-binding motif Receptor-binding motif (RBM) recombinant respiratory robust S1 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine variants virus virus infection virus mutation Virus-like particle virus-like particles Virus-like particles (VLPs) VLP VLPs [DOI] 10.1016/j.nano.2022.102527 PMC 바로가기 [Article Type] Article
Assessment of humoral and cellular immune responses to SARS CoV-2 vaccination (BNT162b2) in immunocompromised renal allograft recipients면역 저하된 신장 동종이식 환자에서 SARS CoV-2 백신(BNT162b2)에 대한 체액 및 세포 면역 반응 평가Article Published on 2022-04-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence Allograft Assessing assessment belatacept BNT162b2 booster vaccinations both groups CD4+ CD8+ T-cell Cellular immune response controls Critical cytomegalovirus deficiencies demonstrated dose Efficacy examined healthy controls humoral IgG IgG response IgG responses immune immune response immune responses Immunocompromised immunosuppressive in both group individual Infection ISP kidney kidney transplant limit memory MMF mycophenolate mycophenolate mofetil no differences of BNT162b2 partial immunity Patient patients peptide peptides Pfizer Prednisone preventing infection protective immunity protocol recipient renal response responses SARS CoV-2 SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe deficiency severity shown spike spike IgG T-cell T-cell immunity T-cell Response T-cell responses tacrolimus vaccination Vaccine [DOI] 10.1111/tid.13813 PMC 바로가기 [Article Type] Article