Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics고 처리량 스크리닝 데이터베이스의 마이닝은 COVID-19 치료제의 잠재적 표적으로서 AP-1 및 자가포식 경로를 나타냅니다Article Published on 2021-03-242022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] addition Anti-SARS-CoV-2 Activity Antiviral AP-1 approved approved drug approved drugs autophagy autophagy pathway Candidates caused class coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 therapeutics CPE Cytopathic effect Data mining database drug drug activity drug library effective effort global pandemic High-throughput screening Hope house human clinical trials in vivo mechanism New coronavirus new coronavirus SARS-CoV-2 phenotypic Potential treatment potential treatments profile pursuit reveal SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly target Target identification therapeutic Viral [DOI] 10.1038/s41598-021-86110-8 PMC 바로가기 [Article Type] Article
The Unique Impact of COVID-19 on Human Gut Microbiome ResearchMedicine Published on 2021-03-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addressed Affect bidirectional relationship change clinical trial clinical trials Community coronavirus COVID-19 COVID-19 virus Diseases faecal microbiota transfer Gut gut microbiome Human hygiene Impact implication increasingly indirect effect influence investigated lockdowns lung Microbiome microbiome research microbiota pandemic population level Potential treatment recruitment repeated Research Sample size statistical analyses Study design Transplant trials unique [DOI] 10.3389/fmed.2021.652464 PMC 바로가기 [Article Type] Medicine
Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids인간 기관지 오르가노이드의 SARS-CoV-2 감염 중 관련 허브 유전자 발현의 탐색 및 검증Genome Database Published on 2021-03-162022-09-10 Journal: Human Genomics [Category] 유전자 메커니즘, [키워드] 3D structure model acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed Bioinformatics analysis bronchial organoid CCL2 CCL5 coronavirus COVID-19 CXCL1 CXCL10 CXCL8 Cytokines DEGs differentially expressed gene Differentially expressed genes downloaded downregulated gene EGF exploration expressed expression feasibility FGF2 FN1 Gene Expression Gene ontology Genes genomes GEO Health help high mortality hub genes Human bronchial organoids human bronchus ICAM1 identify IL1B IL6 immune response in vitro model Infection infection mechanism infection rate Interaction KEGG Kyoto Microarray MMP9 mRNA mRNA expression Novel coronavirus Novel coronavirus infection pandemic Pathogenesis pathway Pathways patients PBMC PBMCs Potential treatment PPI prognostic protein-protein interaction Protein–protein interaction R software respiratory Result SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus significantly suggested System three-dimensional structure Treatment upregulated gene were used [DOI] 10.1186/s40246-021-00316-5 PMC 바로가기 [Article Type] Genome Database
Clinician Attitudes to Using Low-Dose Radiation Therapy to Treat COVID-19 Lung DiseaseCOVID-19 Scientific Communication Published on 2021-03-152022-10-30 Journal: International journal of radiation oncology, biolo [Category] COVID-19, MERS, [키워드] addressed analyzed approach Attitude category Clinical practice clinical setting clinical trial clinician common coronavirus disease COVID-19 current Efficacy ENhance facilitate feasibility identify implementation interview lack Lung disease material Patient patient selection patients with COVID-19 Perspective potential benefit Potential treatment quantification Radiation radiation therapy recruitment required Research resource Result risk subsequent the patient transcribed transfer Transmission Treatment treatment for COVID-19 Trial were recorded [DOI] 10.1016/j.ijrobp.2020.12.003 PMC 바로가기 [Article Type] COVID-19 Scientific Communication
Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma PatientsArticle Published on 2021-03-122022-10-31 Journal: Cancers [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome adenocarcinoma alveolar alveolar epithelial cells Analysis AT2 Cancer CD36 Cell cells cellular distribution Clinical management co-expressed Cohort coronavirus coronavirus disease COVID-19 COVID-19 pandemic death rates Defense DMBT1 elevated enzyme epithelial cell examined Express expressed expression expression level expression profile Features Genes Health HHIP highest Host host protein identify implicated individual Inflammation landscape lung lung adenocarcinoma lung cancer patient lung cancer patients lung cell lung cells lung epithelial Lung epithelial cells Lung inflammation lung neoplasms malignant marker Mortality normal novel coronavirus SARS-CoV-2 offer pandemic pathway patients patients with comorbidity Pneumonia Population positively correlated Potential treatment presenting Proteases proteases Tmprss2 pulmonary raising receptor Respiratory complications Respiratory failure risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 receptor scRNA-seq significantly simple single-cell Single-cell RNA sequencing Single-cell RNA-sequencing Spread symptomatic target the United State therapeutic target tissue TMPRSS2 TMPRSS4 [DOI] 10.3390/cancers13061250 PMC 바로가기 [Article Type] Article
In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2Original Article Published on 2021-03-102022-10-30 Journal: Molecular Therapy [Category] COVID-19, [키워드] absence Abstract anti-viral therapeutics approach CCR5 CD4 cell line cellular co-expressed codon optimization Combination Engineered red blood cells erythrocyte Express expressing expression facilitate fusion protein high expression level HIV-1 Hoffmann Infection Interaction lack neutralization neutralize neutralized nuclei organelle Potential treatment Prevent produced progenitor cell progenitor cells Proteins RBC RBCs receptor receptors red blood cell required SARS-CoV-2 spike transgene trimeric viral entry viral infections viral replication virions [DOI] 10.1016/j.omtm.2021.03.003 PMC 바로가기 [Article Type] Original Article
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19Review Published on 2021-03-092022-10-29 Journal: Stem Cell Reports [Category] COVID-19, SARS, [키워드] Affect animal models ASC benefit Cell challenge COVID-19 COVID-19 pandemic human physiology identify limit Organoid pandemic Pandemics pathogenic virus Potential treatment promise public health SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 pandemic specificity virus [DOI] 10.1016/j.stemcr.2020.11.009 PMC 바로가기 [Article Type] Review
Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2Research Article Published on 2021-03-082022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis antibodies antibody antibody repertoire Antigen B cell coronavirus coronavirus disease COVID-19 cross-neutralizing cross-neutralizing antibody cross-reactive antibody cross-reactivity demonstrated Dromedary epitope epitope mapping Health humans hyperimmune immunoassay immunofluorescence immunogenic immunoprecipitation Immunotherapy investigated linear MERS-CoV Microarray Middle East nanobody Neutralizing peptides Potential treatment Prophylactic Proteins Pseudovirus neutralization assays respiratory syndrome coronavirus S trimer SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 proteins Sequencing seropositive specificity Support tested therapeutic agent Treatment [DOI] 10.1172/jci.insight.145785 PMC 바로가기 [Article Type] Research Article
Antiviral Activity of the Propylamylatin TM Formula against the Novel Coronavirus SARS-CoV-2 In Vitro Using Direct Injection and Gas Assays in Virus SuspensionsArticle Published on 2021-03-052022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Muscodor albus activity acute respiratory syndrome Antiviral antiviral agent Antiviral effect antiviral therapy approved body temperature Combination component components coronavirus Course COVID-19 Direct effective evaluated experiment faster Formula global public health inactivated inactivation Infectious virus injection investigated majority Mild Moderate COVID-19 novel novel coronavirus disease occurred Plaque assay Potential treatment propionic acid provided quantified reduction in Remdesivir SARS-CoV-2 severe COVID-19 Suspension synergy temperature therapeutic Treatment undetectable VERO E6 cells viral inactivation virus Volatile organic compounds Volume [DOI] 10.3390/v13030415 PMC 바로가기 [Article Type] Article
Tocilizumab administration is associated with the reduction in biomarkers of coronavirus disease 2019 infection토실리주맙 투여는 코로나바이러스 질병 2019 감염의 바이오마커 감소와 관련이 있습니다Meta-Analysis Published on 2021-03-012022-08-31 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 95% CI administration Analysis article benefit Biomarker Biomarkers C-reactive protein caused confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection D-dimer database death case dimer effective Effectiveness Evidence ferritin immunomodulator increment Infection interleukin interleukin-6 life lymphocyte Lymphocyte count mean difference Meta-analysis number of death Patient Potential treatment procalcitonin PubMed Central random reducing reduction reduction in retrieved searched severity the disease Tocilizumab Treatment [DOI] 10.1002/jmv.26698 PMC 바로가기 [Article Type] Meta-Analysis