Myocardial Involvement in COVID-19: an Interaction Between Comorbidities and Heart Failure with Preserved Ejection Fraction. A Further Indication of the Role of InflammationComorbidities of Heart Failure (J. Tromp, Section Editor) Published on 2021-04-222022-10-31 Journal: Current heart failure reports [Category] COVID-19, MERS, SARS, [키워드] abnormality Activation Affect association cardiac Cardiomyopathy cause Chronic kidney disease Comorbidity Course COVID-19 COVID-19 patient diabetes diastolic disease dysfunction echocardiographic Ejection Ejection fraction failure fibrosis healthy heart heart failure Heart failure with preserved ejection fraction HFpEF hospitalized patient hypertension impairment independent risk factor indication Inflammatory Involvement majority Myocardial inflammation obesity Patient patients predictor preserved Prevalence pro-inflammatory state pulmonary hypertension recent reveal risk role SARS-COV-2 infection the disease ventricular dysfunction with COVID-19 [DOI] 10.1007/s11897-021-00509-y PMC 바로가기 [Article Type] Comorbidities of Heart Failure (J. Tromp, Section Editor)
The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime Reviews Published on 2021-04-212022-10-05 Journal: Modern pathology : an official journal of the Unit [Category] 바이오마커, 진단, [키워드] Analysis Autopsy biopsy carried Cell change complex COVID-19 current Diffuse alveolar damage discrepancies Endothelial cell endothelial cells epithelial explain feature histology hyaline membranes IDO immune interstitial pneumonia lung Lung compliance Morphological observation Occurrence Pathogenesis pathogenesis of COVID-19 pathogenic PD-L1 phosphorylated Pneumonia presenting preserved radiological Respiratory failure SARS-CoV-2 STAT3 subject thromboembolic disease Vascular [DOI] 10.1038/s41379-021-00808-8 [Article Type] Reviews
Childbirth Care among SARS-CoV-2 Positive Women in ItalyArticle Published on 2021-04-162022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Asymptomatic average Birth Breastfeeding Care Childbirth Clinical practice Cohort collected Contact COVID-19 Evidence First wave hospital Hospital admission Infant information Italian Italy mother National New coronavirus Newborn outcome outcomes pandemic Perinatal care positive Pregnancy preserved prospective cohort study raised remained Safe SARS-CoV-2 SARS-COV-2 infection secure separated spread to Support was performed women [DOI] 10.3390/ijerph18084244 PMC 바로가기 [Article Type] Article
The C-Terminal Domain of Nef mut Is Dispensable for the CD8 + T Cell Immunogenicity of In Vivo Engineered Extracellular VesiclesArticle Published on 2021-04-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Antigen C-terminal C-terminus CD8 CD8+ T cell immunity cells deleted diffusion distal DNA DNA immunization effective elicit EVs expressing Extracellular Extracellular vesicles full-length fused Heterologous HIV-1 Nef HPV vaccines humans immune response Immunity immunogenicity injection isoform MOST not affect Perspective preserved Protein released S1 and S2 safety profile SARS-CoV-2 SARS-CoV-2 vaccines stability T cell translation tumor antigen Vaccine vaccine platform vector Vesicle [DOI] 10.3390/vaccines9040373 PMC 바로가기 [Article Type] Article
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protectionSARS-CoV-2에 대한 인간 중화 항체는 최적의 치료 보호를 위해 온전한 Fc 효과기 기능을 필요로 합니다Article Published on 2021-04-012022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Administered antibody benefit caused CD8 CD8+ CD8+ T cells Cell clinical trials COVID-19 pandemic Depletion disease effector function function hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IMPROVE in vivo Infection Inflammation innate immune loss-of-function lung Lung disease Lung infection lung; mAb mAbs mechanism of action mice mitigate monocyte Monocytes mouse model Neutralizing Neutralizing antibodies neutralizing antibody Pathogenesis phenotype preserved Prophylaxis reduce required respiratory Respiratory mechanics RNA RNA sequencing SARS-CoV-2 Signaling T cell T cells therapeutic therapy tissue repair transcriptional variant Virological [DOI] 10.1016/j.cell.2021.02.026 PMC 바로가기 [Article Type] Article
Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold StorageSARS-CoV-2 Spike G614 변종의 안정성이 냉장 보관 후 D614 변종의 안정성을 능가함Research Article Published on 2021-03-312022-09-10 Journal: mSphere [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding ability circulating circulation Cold cold chain cold storage conditions contribute coronavirus D614 mutation D614 variant D614G mutation dominant variant explain food freezing handling high stability higher efficiency infectious integrity Mutation Precaution precautions predominant preserved refrigeration respiratory RNA integrity SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein Spread stability storage temperature the spike protein variant variants Viral Viral RNA viral spread virus [DOI] 10.1128/mSphere.00104-21 PMC 바로가기 [Article Type] Research Article
Coronavirus disease 2019 (COVID-19) and QTc prolongationObservational Study Published on 2021-03-302022-10-27 Journal: BMC Public Health [Category] COVID-19, [키워드] age angiotensin-converting enzyme inhibitor arrhythmia baseline cardiovascular disease Chronic kidney disease Combination comparable congestive heart failure contribute Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients develop diagnosis of COVID-19 drug Ejection fraction End-stage renal disease ESRD hospital Hospitalization Hospitalized Hydroxychloroquine Infection Injury ischemic heart disease less Mortality objective Older Patient preserved QT prolongation QTc QTc interval QTC prolongation Result retrospective two groups USA ventricular virus [DOI] 10.1186/s12872-021-01963-1 PMC 바로가기 [Article Type] Observational Study
Coronavirus disease 2019 (COVID-19) and QTc prolongationObservational Study Published on 2021-03-302022-10-27 Journal: BMC Public Health [Category] Coronavirus, COVID-19, SARS, [키워드] age angiotensin-converting enzyme inhibitor arrhythmia baseline cardiovascular disease Chronic kidney disease Combination comparable congestive heart failure contribute Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients develop diagnosis of COVID-19 drug Ejection fraction End-stage renal disease ESRD hospital Hospitalization Hospitalized Hydroxychloroquine Infection Injury ischemic heart disease less Mortality objective Older Patient preserved QT prolongation QTc QTc interval QTC prolongation Result retrospective two groups USA ventricular virus [DOI] 10.1186/s12872-021-01963-1 PMC 바로가기 [Article Type] Observational Study
Coronavirus disease 2019 (COVID-19) and QTc prolongation코로나바이러스 질병 2019(COVID-19) 및 QTc 연장Observational Study Published on 2021-03-302022-09-01 Journal: BMC Public Health [Category] 임상, 진단, [키워드] ACEi age angiotensin angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors arrhythmia Azithromycin baseline cardiac injury cardiovascular disease Chronic kidney disease Combination comparable congestive heart failure contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients develop diagnosis of COVID-19 drug Ejection fraction End-stage renal disease ESRD heart disease hospital Hospitalization Hospitalized Hydroxychloroquine Infection Injury ischemic heart disease Kidney disease less Mortality objective observational study Older Older age Patient preserved prolongation QT prolongation QTc QTc interval QTC prolongation renal disease Result retrospective two groups USA ventricular ventricular arrhythmias virus [DOI] 10.1186/s12872-021-01963-1 PMC 바로가기 [Article Type] Observational Study
Structural analysis of viral ExoN domains reveals polyphyletic hijacking eventsResearch Article Published on 2021-03-172022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Analysis arenavirus cellular comparable conserved COVID-19 domain event exonuclease exonucleases genomes growth Host innate immune lack preserved Proofreading Protein RdRP reported reveal RNA virus RNA-dependent RNA polymerase sequence Signaling structural homology therapeutic strategy Viral proteins [DOI] 10.1371/journal.pone.0246981 PMC 바로가기 [Article Type] Research Article