Respiratory distress syndrome – Page 12 – Communicable Diseases Research

Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial

중등도에서 중증 ARDS 환자의 폐 투과성 부종을 치료하기 위해 순차적으로 다중 상승하는 solnatide의 안전성 및 예비 효능 - 무작위, 위약 대조, 이중 맹검 시험

Randomized Controlled Trial

Published on 2021-09-202022-09-10
Journal: Trials [Category] SARS, 비임상, 임상,

Role of CT angiography in detecting acute pulmonary embolism associated with COVID-19 pneumonia

COVID-19 폐렴과 관련된 급성 폐색전증을 검출하는 데있어 CT 혈관 조영술의 역할

Chest Radiology

Published on 2021-09-172022-09-01
Journal: La Radiologia Medica [Category] 진단,

[키워드] acute pulmonary embolism acute respiratory distress acute respiratory distress syndrome acute respiratory symptom affected Analysis ARDS arterial oxygen saturation association C-reactive protein caused characterized Chest CT Chi-square chi-square tests clinical and laboratory parameters clinical feature collecting data Comorbidities Comorbidity consecutive patient contrast agent coronavirus coronavirus disease cough COVID-19 COVID-19 infection CRP value CRP values CT angiography CT scan D-dimer D-dimer level D-dimer levels detect Dyspnea elevated fatigue global pandemic help illness onset IMPROVE Inclusion inclusion criteria intensive care unit Intravenous injection Iomeprol Laboratory parameters management mechanical ventilation median time mono Nasopharyngeal swab Nasopharyngeal swab specimens outcomes oxygen Patient patients patients with PE patients without PE performed persistent cough Pneumonia positive presence of comorbidities pulmonary CT Pulmonary embolism real-time reverse-transcriptase polymerase-chain-reaction reduction in required respiratory respiratory distress Respiratory distress syndrome Result role rRT-PCR SARS-COV-2 infection selected significant increase significantly significantly higher significantly more statistical analysis syndrome those without PE was performed Wilcoxon rank-sum with COVID-19
[DOI] 10.1007/s11547-021-01415-y PMC 바로가기 [Article Type] Chest Radiology

COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France

COVID-19 환자는 프랑스 남동부에있는 SARS-COV-2 UK-Variant와 관련된 연령, 동반 성 프로파일 및 임상 프리젠 테이션

Observational Study

Published on 2021-09-162022-09-01
Journal: Scientific Reports [Category] SARS, 변종, 임상, 진단,

[키워드] Affect age analyzed Characteristics circulating variants Comorbidity COVID-19 patient described emergency department Epidemiology France French Riviera higher risk hospital Hospitalized hospitalized patient hospitalized patients ICU incidence rate increasingly Infectious disease Infectious diseases Modification modifications Nice observational study outcome pandemic Patient patients PCR performed positive sample profile proportion provided representing Respiratory distress syndrome SARS-CoV-2 Sequencing Spread the SARS-CoV-2 traits Transmissibility university university hospital variant viral infection
[DOI] 10.1038/s41598-021-95067-7 PMC 바로가기 [Article Type] Observational Study

Interleukin-1RA Mitigates SARS-CoV-2–Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice

Interleukin-1RA는 인간화 된 K18-HASE-2 마우스에서 SARS-COV-2- 유도 된 염증성 폐 혈관 누출 및 사망률을 완화시킨다.

10008

Published on 2021-09-092022-09-10
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] Fulltext, MERS, SARS, 바이오마커,

[키워드] activated activation of inflammasome acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Anakinra blockade cadherin caspase characterized content coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Digital Digital Content domain downregulation edema Endothelial cell endothelial cells human lung humanized Hyperinflammatory ies IL-1 IL-1 receptor antagonist IL-1ra immune response immunomodulatory therapy Infection Inflammasome Inflammatory Injury innate immune interleukin-1 junction junctions leakage lung lung edema lung endothelial Lungs mechanism mice morbidity morbidity and mortality NLR NLRP3 Prevent prevented Protein provide pyroptosis receptor receptor antagonist receptor signaling respiratory respiratory distress Respiratory distress syndrome Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Signaling significantly increased survival susceptible syndrome text Treatment Vascular Vascular injury vascular system injur VE-cadherin
[DOI] 10.1161/ATVBAHA.121.316925 PMC 바로가기 [Article Type] 10008

Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS

Comment

Published on 2021-09-092022-10-04
Journal: NPJ Regenerative Medicine [Category] 임상,

Fungal Genomics in Respiratory Medicine: What, How and When?

호흡기 의학의 진균 유전체학: 무엇을, 어떻게, 언제?

Review

Published on 2021-09-072022-09-10
Journal: Mycopathologia [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome advance aspergillosis Aspergillus fumigatus azole cause of death caused coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical death Diagnosis Diagnostic method diagnostics early diagnosis form fungal Fungal infection fungal infections fungal pathogen fungal pathogens Genomics Health higher risk Immunocompromised patients include Infection infections molecular molecular diagnostics Mortality Mucormycosis Mycoses pathogen Pathogens Patient patient survival pulmonary aspergillosis respiratory respiratory diseases respiratory distress Respiratory distress syndrome respiratory infections resulting shown syndrome treated triazole
[DOI] 10.1007/s11046-021-00573-x PMC 바로가기 [Article Type] Review

Ruxolitinib in severe COVID-19: Results of a multicenter, prospective, single arm, open-label clinical study to investigate the efficacy and safety of ruxolitinib in patients with COVID-19 and severe acute respiratory syndrome

Clinical Trial

Published on 2021-09-072022-10-05
Journal: Revista de la Facultad de Ciencias Médicas (Córd [Category] 임상,

[키워드] according to protocol acute respiratory syndrome added Admission Adult anti-inflammatory effect caused circulating cytokines clinical study coronavirus Coronavirus infections COVID-19 COVID-19 patients COVID-19 pneumonia patient Critical determine distress Effect Efficacy and safety elevated English Host ill patient immune response intensive care Janus kinase Janus kinase inhibitors lower mortality mechanical ventilation multicenter Open-label organ injury Patient patients patients with COVID-19 Phase 2 study primary endpoint prospectivo receiving reduction reported Respiratory distress syndrome Result ruxolitinib ruxolitinib dose side Spanish Standard of care study drug Toxicity Treatment
[DOI] 10.31053/1853.0605.v78.n3.32800 PMC 바로가기 [Article Type] Clinical Trial

Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study

Observational Study

Published on 2021-09-062022-10-04
Journal: Scientific Reports [Category] SARS, 임상,

[키워드] 95% CI admitted to ICU Affect age contrary coronavirus disease COVID-19 COVID-19 adult patients COVID-19 patient current Day Efficacy Endotracheal intubation enrolled examined Factor greater ICU ICU admission ICU patient ICU Patients In-hospital in-hospital mortality inclusion criteria independent risk factor intensive care Intubated male median age Mortality multicenter multicenter observational study NIV Non-invasive non-invasive ventilation not affect outcome Patient patient survival potential risk predictor provided receiving Respiratory distress syndrome Respiratory failure SARS-CoV-2 SARS-COV-2 infection study period were assessed
[DOI] 10.1038/s41598-021-96762-1 PMC 바로가기 [Article Type] Observational Study

S100A8 may govern hyper-inflammation in severe COVID-19

S100A8은 심각한 COVID-19에서 과염증을 지배할 수 있습니다.

Article

Published on 2021-09-012022-09-11
Journal: FASEB journal : official publication of the Federa [Category] SARS, 변종, 진단, 치료제,

[키워드] accumulating Activation acute respiratory distress acute respiratory distress syndrome affected ARDS Biomarker calcium calcium-binding protein cells chronic myeloid leukemia clinical information Coagulation coagulation cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-associated ARDS disease disease severity effective Elimination endotoxin Evidence extrinsic form herd immunity homeostatic hyper-inflammation Hypothesis Immunity include increased vascular permeability Inflammation Interaction leukemia Ligand lung molecular target mortality rate myeloid cells myeloid-derived suppressor cells overcome pandemic Pathogens predict reagent receptor recruitment respiratory distress Respiratory distress syndrome S100A8 S100A9 severe COVID-19 severe forms of COVID-19 similarity situation syndrome TLR4 to define Toll-like receptor Treatment upregulated upregulation Vaccine vascular permeability
[DOI] 10.1096/fj.202101013 PMC 바로가기 [Article Type] Article

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

7-케토콜레스테롤: 바이러스 감염에 미치는 영향 및 COVID-19에 대한 가설적 기여

Review

Published on 2021-09-012022-09-11
Journal: The Journal of steroid biochemistry and molecular [Category] MERS, 바이오마커, 치료제,

[키워드] 7-Ketocholesterol activate activities activity acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapies adjuvant therapy affected Age-related macular degeneration alveolar cells Alzheimer's disease Anti-viral antiviral activity Apoptosis appear assumed auto-oxidation autophagy Biomarker cancers cardiovascular diseases cell death cholesterol chronic inflammatory bowel diseases concentrations contribute contributing to COVID-19 COVID-19 patients Deleterious density disease Diseases Effect food hypothetical Inflammatory bowel disease inflammatory bowel diseases involved macular degeneration outcome Oxidation oxidized oxysterol Oxysterols pathophysiology pro-inflammatory produced promote provided recent respiratory distress Respiratory distress syndrome resulting SARS-CoV-2 serum shown side chain significantly suggested syndrome toxic effect toxic effects Viral Viral diseases viral infection
[DOI] 10.1016/j.jsbmb.2021.105939 PMC 바로가기 [Article Type] Review