High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19Clinical Trial Published on 2022-12-132023-07-10 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), [키워드] chemokine Predictive markers Respiratory distress syndrome SARS-CoV-2 Viral infection. [DOI] 10.1093/infdis/jiac313 PMC 바로가기 [Article Type] Clinical Trial
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Circulating Ubiquitous RNA, A Highly Predictive and Prognostic Biomarker in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients순환 유비쿼터스 RNA, 입원한 코로나바이러스 질환 2019(COVID-19) 환자의 고도로 예측하고 예후가 좋은 바이오마커Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Biomarker Biomarkers Blood cell lysis Chain Reaction circulating Clinical management clinical monitoring clinical outcomes Clinical severity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients Critical ddPCR death develop disease severity Diseases evaluate Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Infectious diseases Invasive mechanical ventilation lung cell management marker multi-organ failure organ injury overall survival Patient plasma polymerase chain polymerase chain reaction predict Predictive predictive and prognostic biomarkers prognostic Prognostic biomarkers quantification respiratory respiratory distress Respiratory distress syndrome RNA RNase P RNAseP SARS-CoV-2 SARS-CoV-2 and RNAseP RNAemia severe acute respiratory syndrome Coronavirus severe and critical patients severity significantly survival syndrome tissue injury tissue/cell lysis biomarker. Viral [DOI] 10.1093/cid/ciab997 PMC 바로가기 [Article Type] Article
Pulmonary embolism severity index predicts adverse events in hospitalized COVID-19 patients: A retrospective observational study: PESI/sPESI and COVID-19 StudyResearch article Published on 2022-08-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 진단, 치료기술, [키워드] 95% confidence interval acute respiratory distress Admission adverse event adverse events age Analysis can be used cause clinically clinically suspected COVID-19 death evaluated hospital hospitalized COVID-19 hospitalized COVID-19 patient in-hospital mortality in-hospital mortality rate incidence independent risk factor intensive care invasive investigated measurement mechanical ventilation multivariate logistic regression noninvasive objective Odds ratio participant patients with COVID-19 polymerase chain positive predict Pulmonary embolism pulmonary embolism severity index (PESI) Respiratory distress syndrome Result retrospective scoring system sensitivity setting severity simplified PESI (sPESI) specificity study population syndrome the median Thromboembolic event venous Venous Thromboembolism women [DOI] 10.1053/j.jvca.2022.08.009 [Article Type] Research article
Masseter muscle pressure injury: First report of a prone position complication in patients with COVID-19교근 근육 압박 부상: COVID-19 환자의 엎드린 자세 합병증의 첫 보고Case Reports Published on 2022-08-012022-09-11 Journal: Intensive & critical care nursing [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Case report Complication COVID-19 COVID-19 patients deep Deep tissue injury distress facial Injury intensive care intensive care unit intensive care units management Masseter muscle obese patients with COVID-19 pressure Pressure injury Prevent prone Prone position Prophylactic respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Side effect syndrome tissue tissue injury [DOI] 10.1016/j.iccn.2022.103251 PMC 바로가기 [Article Type] Case Reports
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proteomics. proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Immunomodulation of Mesenchymal Stem Cells in Acute Lung Injury: From Preclinical Animal Models to Treatment of Severe COVID-19급성 폐 손상에서 중간엽 줄기 세포의 면역 조절: 전임상 동물 모델에서 중증 COVID-19 치료까지Review Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal animal model antiviral properties antiviral property caused Cell Cell therapy clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm highlight immunomodulation immunomodulatory Infection lung Lung injury mass Mesenchymal stem cells mesenchymal stem cells. Model Mortality MSC MSC therapy MSCs outcome pandemic Pathogenesis patients with COVID-19 potential mechanism potential mechanisms Preclinical public health Reinfection respiratory distress Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus STEM stem cells syndrome the SARS-CoV-2 tissue repair treat vaccination vaccine breakthrough infection vaccine breakthrough infections Viral variants [DOI] 10.3390/ijms23158196 PMC 바로가기 [Article Type] Review
Updated Living Systematic Review and Meta-analysis of Controlled Trials of Mesenchymal Stromal Cells to Treat COVID-19: A Framework for Accelerated Synthesis of Trial Evidence for Rapid Approval-FASTER ApprovalCOVID-19를 치료하기 위한 중간엽 간질 세포의 통제된 시험에 대한 업데이트된 살아있는 체계적인 검토 및 메타 분석: 신속한 승인-빠른 승인을 위한 시험 증거의 가속화된 합성을 위한 프레임워크Meta-Analysis Published on 2022-07-202022-09-11 Journal: Stem cells translational medicine [Category] 임상, [키워드] accelerate accelerated acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approval ARDS Clinical studies clinical study conducted Consistency Control Controlled controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical death Endpoint evaluate Evidence Exosomes Extracellular Extracellular vesicles facilitate framework heterogeneity Hospital stay identify IMPROVE ISCT Master protocol mean difference Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells Meta-analysis Microvesicles moderate Mortality MSC MSC-EVs exosomes MSCs non-randomized study outcome Oxygenation Patient Pneumonia PROSPERO protocol random-effect random-effects Random-effects meta-analysis Randomized controlled trial Rapid reduce reduce mortality Relative risk reported respiratory distress Respiratory distress syndrome review risk of bia risk of death RoB SARS-CoV-2 Sepsis severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome coronavirus 2. Society stromal cell stromal cells synthesis systematic review treat Treatment [DOI] 10.1093/stcltm/szac038 PMC 바로가기 [Article Type] Meta-Analysis
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcription factors. transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre randomised controlled trial: the PROVID-19 protocol깨어 있는 엎드린 자세가 일반 병동에 입원한 표준 산소 요법을 받는 COVID-19 환자의 기계적 호흡 지원 또는 사망을 방지합니까? 다기관 무작위 대조 시험: PROVID-19 프로토콜Article Published on 2022-07-082022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome approved ARDS Awake prone positioning body mass body mass index composite endpoint COVID-19 COVID-19 patient COVID-19 patients death death in COVID-19 decrease defined Ethics France hospitalised hypothesised hypoxaemia IMPROVE Infectious diseases Informed consent intervention group intubation investigator-initiated mechanical respiratory multicentre Non-intubated non-invasive ventilation Noninvasive ventilation Oxygenation Patient patients with ARDS peer-reviewed Prevent prone Prone position prone positioning protocol randomised randomised controlled receive registration number respiratory distress Respiratory distress syndrome respiratory infections respiratory infections. responsible Safe severity Standard of care standard oxygen therapy Stratification submitted Support survival syndrome the ethics committee Treatment treatment failure Trial usual care usual care alone [DOI] 10.1136/bmjopen-2021-060320 PMC 바로가기 [Article Type] Article