Prevalence and seasonality of viral respiratory infections in a temperate climate region: A 24-year study (1997-2020)온대 기후 지역에서 바이러스성 호흡기 감염의 유병률과 계절성: 24년 연구(1997-2020)Article Published on 2022-07-012022-09-11 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Adults age analyzed Barcelona children Climate clinical collected data determine distribution Epidemiology examined Frequency Gender groups H1N1pdm09 infections Influenza influenza A influenza A virus knowledge molecular other respiratory virus Other respiratory viruses Pandemics Patient positive positive sample Prevalence provide remained respiratory respiratory infections respiratory syncytial virus respiratory virus Respiratory virus infections respiratory viruses SARS-CoV-2 season seasonality severe respiratory infection severe respiratory infections significantly higher Spain specimen study period Temperate climate Throughout the study viral respiratory infection virus virus infection viruses warm [DOI] 10.1111/irv.12972 PMC 바로가기 [Article Type] Article
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2SARS-CoV-2에 대한 활성을 갖는 광범위한 1차 항바이러스제로서의 거대분자 바이러스 진입 억제제Article Published on 2022-07-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analyzed antiviral activity broad-spectrum antivirals Cell culture cell entry clinical isolates entry inhibitors gold Gold nanoparticle in vitro in vivo inhibitor inhibitors inhibitory activity investigated isolate macromolecular macromolecules mice pathogen Pathogens polyanions quantified respiratory syncytial virus respiratory syncytial virus (RSV). respiratory viral respiratory viruses Result RSV SARS-CoV-2 shown STYRENE sulfonate tested translational variants variants of concern viral cell virus viruses [DOI] 10.1002/advs.202201378 PMC 바로가기 [Article Type] Article
Tracheal Aspirate and Bronchoalveolar Lavage as Potential Specimen Types for COVID-19 Testing Using the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSVCepheid Xpert Xpress SARS-CoV-2/Flu/RSV를 사용한 COVID-19 검사를 위한 잠재적 표본 유형으로서의 기관 흡인 및 기관지폐포 세척Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition anticipated approved aspirate BAL Bronchoalveolar lavage bronchoalveolar lavage sample bronchoalveolar lavage samples Cepheid community transmission COVID-19 criteria Cycle threshold values Diagnosis diagnostic test evaluated Evidence help hospital implication Influenza influenza A influenza B lab lavage Lower respiratory tract lower respiratory tract specimen management multiplex overcome Patient PCR test performance platform point of care positive Potential Precision provide Rapid diagnostic test reproducibility respiratory respiratory specimen respiratory syncytial virus SARS-CoV-2 SARS-CoV-2 detection specimen specimens target tested Testing the SARS-CoV-2 tracheal Type upper respiratory tract Xpert Xpress SARS-CoV-2 assay [DOI] 10.1128/spectrum.00399-22 PMC 바로가기 [Article Type] Article
Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymeraseArticle Published on 2022-06-242022-10-06 Journal: Science Advances [Category] 진단, [키워드] Administered affinity Compound disease docking domain Efficacy Human airway epithelium Immunocompromised in vitro in vivo Infant inhibitor molecular target Organoid polymerase resistance respiratory respiratory infection respiratory syncytial virus RNA synthesis RNA-dependent RNA polymerase RSV therapeutic unique virus [DOI] 10.1126/sciadv.abo2236 PMC 바로가기 [Article Type] Article
Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients표적 포획 시퀀싱은 성인 혈액학 환자들 사이에서 호흡기 세포융합 바이러스 B 감염의 단일 클론 발병을 보여줍니다Article Published on 2022-06-212022-09-11 Journal: Antimicrobial Resistance and Infection Control [Category] Coronavirus, 변종, 치료기술, 치료제, [키워드] Analysis approach capture Capture probe sequencing capture sequencing cause caused circulating clinical samples contribute contributed Course COVID-19 pandemic demonstrated described disease Early detection effective Genome hematologic Hematologic malignancy hematological hematology hospital Hospital staff increased risk Infection infection control integration involved Isolation measure Measures molecular molecular analysis Molecular epidemiology monoclonal occur oligonucleotide probe outbreak Patient probe respiratory respiratory syncytial virus respiratory tract infection Respiratory tract infections respiratory virus respiratory viruses reveal RSV sequence Sequencing significantly strain target targeted prevention transmission pathways variant virus ward was performed whole-genome sequencing Winter [DOI] 10.1186/s13756-022-01120-z PMC 바로가기 [Article Type] Article
Antibodies to combat viral infections: development strategies and progressReview Published on 2022-06-202022-10-05 Journal: Nature Reviews Drug Discovery [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료제, [키워드] acute respiratory syndrome antibody Antigen boost can be used caused Characteristics coronavirus COVID-19 COVID-19 pandemic develop Diseases Ebola virus effort Emergency use ENhance HCMV Human Cytomegalovirus immune responses in viral Infection Influenza mAb mAbs Neutralizing protective immune response Proteins Region respiratory syncytial virus RSV SARS-CoV-2 specificity stimulated therapeutic Vaccine design Vaccine development viral infection virus [DOI] 10.1038/s41573-022-00495-3 [Article Type] Review
Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article
Targeted Virome Sequencing Enhances Unbiased Detection and Genome Assembly of Known and Emerging Viruses-The Example of SARS-CoV-2표적 바이롬 시퀀싱은 알려진 바이러스와 새로 출현하는 바이러스의 편견 없는 탐지 및 게놈 조립을 향상시킵니다-SARS-CoV-2의 예Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adenovirus assembly cDNA cDNA synthesis characterization coronavirus COVID-19 coxsackievirus cytomegalovirus depleting detection Detection sensitivity DNA and RNA dsDNA Efficiency emerging viruses equimolar evaluate followed by genetic diversity genome assembly genomic H3N2 Illumina Influenza influenza A influenza A virus less mapped Nanopore nanopore sequencing NGS NGS diagnostics OC43 pathogen Pathogens point-of-care pool positive sample proof remained respiratory syncytial virus RNA virus RNA viruses SARS-CoV-2 sequence Sequencing strain Strains synthesis target enrichment total read viral genomes virome sequencing. virus viruses was performed [DOI] 10.3390/v14061272 PMC 바로가기 [Article Type] Article
An all-in-one point-of-care testing device for multiplexed detection of respiratory infectionsArticle Published on 2022-06-082023-06-16 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, [키워드] Adenovirus COVID-19 immunoassay Influenza Microfluidics respiratory syncytial virus SARS-CoV-2 [DOI] 10.1016/j.bios.2022.114454 PMC 바로가기 [Article Type] Article
N-chlorotaurine is highly active against respiratory viruses including SARS-CoV-2 (COVID-19) in vitroArticle Published on 2022-05-232023-06-30 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, [키워드] Anti-infective antiseptic Antiviral COVID-19 Influenza N-chlorotaurine respiratory syncytial virus respiratory tract [DOI] 10.1080/22221751.2022.2065932 PMC 바로가기