Molecular characterization, phylogenetic and variation analyses of SARS-CoV-2 strains in TurkeyResearch Article Published on 2021-10-072022-10-31 Journal: Future Microbiology [Category] COVID-19, MERS, SARS, [키워드] Analysis B.1 B.1.1 clades Clusters Complete Complete genome sequencing COVID-19 European Genome genome analysis initiative isolate Lineage MiSeq patients Phylogenetic Phylogenetic analysis platform polymorphism SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 strain sequence Sequencing similarity single-nucleotide SNP SNP analysis the SARS-CoV-2 Turkey unique SNP Variation viral genome sequence was used [DOI] 10.2217/fmb-2021-0118 PMC 바로가기 [Article Type] Research Article
N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strainsResearch Article Published on 2021-10-042022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Acquired acute respiratory syndrome Affect affecting Ala Amino acid caused convalescent plasma coronavirus Coronaviruses Critical Deletion Epidemiological study epitope global pandemic identify Immune escape immunoreactivity implicated Interaction less Mutation N-terminal domain N-terminal domain mutations neutralizing antibody NTD RBD Receptor binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 strain Spike protein strain Strains the RBD the SARS-CoV-2 the SARS-CoV-2 genome the spike protein Transmissibility variety Virus evolution virus infectivity Wuhan strain [DOI] 10.1016/j.csbj.2021.10.004 PMC 바로가기 [Article Type] Research Article
Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infectionsSARS-COV-2 델타 변형의 전염 사건은 다수의 백신 혁신 감염을 보여줍니다.Research Article Published on 2021-10-012022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele allergy Alpha Alpha variant Amplicon Analysis B.1.617.2 BNT162b2 causal variant Chain Reaction circulating SARS-CoV-2 variants Cluster college coronavirus COVID-19 delta variant described determine filtered fraction funding GATK Genome global public health highest identify immune evasion Infection Infectious disease Infectious diseases Medicine Moderna mRNA-1273 nasopharyngeal swabs Panel Part Patient Pfizer polymerase chain polymerase chain reaction qPCR Quantitative quantitative polymerase chain reaction respiratory Result reveal risk SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 strain SARS-CoV-2 variant sequenced Sequencing severe acute respiratory syndrome Coronavirus supplementary material supported Swab tested toolkit Transmissibility Vaccine vaccine breakthrough infection variant Viral [DOI] 10.1186/s12916-021-02103-4 PMC 바로가기 [Article Type] Research Article
Feasibility of neighborhood and building scale wastewater-based genomic epidemiology for pathogen surveillance병원체 감시를 위한 인근 및 건물 규모의 폐수 기반 게놈 역학의 타당성Article Published on 2021-10-012022-09-11 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] applicability benefit causative agent Chain Reaction circulating clades Community complex conducted COVID-19 COVID-19 pandemic COVID-19 patient demonstrated detect determine diagnostics Efficacy Epidemiology feasibility Genome genomic hospital identify information Local MONITOR Mutation mutation analysis neighborhood nonsynonymous mutation Nonsynonymous mutations Nursing nursing home occur outbreak pandemic pathogen Pathogens polymerase chain polymerase chain reaction positive profile qPCR Quantitative quantitative polymerase chain reaction RNA sequencing RNAseq sampling SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains Sequencing Surveillance Targeted genome sequencing total RNA treated Treatment Vaccine Viral load wastewater wastewater based epidemiology [DOI] 10.1016/j.scitotenv.2021.147829 PMC 바로가기 [Article Type] Article
Cross-neutralization of SARS-CoV-2 B.1.1.7 and P.1 variants in vaccinated, convalescent and P.1 infected백신 접종, 회복기 및 P.1 감염자에서 SARS-CoV-2 B.1.1.7 및 P.1 변이체의 교차 중화Article Published on 2021-10-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 변종, 진단, [키워드] (alpha acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha antibodies antibody B.1.1.7 BNT162b2 BNT162b2 vaccine candidate Candidates cohorts convalescent coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Donor enrolled evaluate evaluated exit human sera Immunity less neutralization potency neutralized Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody P.1 P.1 variant pandemic Patient plasma Protective reduction respiratory SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-COV-2 infection SARS-CoV-2 strain serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly significantly lower strain tested the SARS-CoV-2 titer titers Vaccine variant variants of concern VOCs wild-type [DOI] 10.1016/j.jinf.2021.07.019 PMC 바로가기 [Article Type] Article
Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh방글라데시 SARS-CoV-2 게놈의 돌연변이 빈도의 시간적 풍경: 방글라데시에서 진행 중인 발병의 가능한 의미Article Published on 2021-10-012022-09-11 Journal: Virus Genes [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] age Analysis association Bangladesh change circulating condition conserved country COVID-19 D614G D614G mutation envelope envelope protein Evolution facilitate Factor Frequency function Genome GISAID Helicase implication intrinsic majority Model molecular phylogeny Mutation N protein nonspecific NSP11 NSP2 Nsp3 Nsp9 nucleocapsid protein ORF ORF3a ORF7b outbreak P323L performed platform Protein protein structure RdRP reference genome S2 domain SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 propagation SARS-CoV-2 strain selective sequenced Sex Spike protein strain susceptibility Temporal the Spike unique Vaccine development [DOI] 10.1007/s11262-021-01860-x PMC 바로가기 [Article Type] Article
Study on SARS-CoV-2 strains in Iran reveals potential contribution of co-infection with and recombination between different strains to the emergence of new strains이란의 SARS-CoV-2 균주에 대한 연구는 새로운 균주의 출현에 대한 다른 균주와의 공동 감염 및 재조합의 잠재적 기여를 보여줍니다Article Published on 2021-10-012022-09-11 Journal: Virology [Category] SARS, 변종, [키워드] addition circulating clade Co-infection contribute FIVE Genome genotyped genotyping Haplotype haplotypes individuals Infection Iran isolate isolates mutations new SARS-CoV-2 new strain nine nucleotide partner passage PCR amplicons prevalent random recombinant Recombinant genomes Recombination reveal RNA SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains significantly single nucleotide strain Strains Tag Tag nucleotide genotyping. variant variants virus [DOI] 10.1016/j.virol.2021.06.004 PMC 바로가기 [Article Type] Article
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2치명적인 마우스 적응 SARS-CoV-2의 특성 및 구조적 기초Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 adaptation age Amino acid amino acid substitutions Analysis animal hosts animal model animal models binding affinity cause characterization complex cryo decrease deep deep sequencing ENhance Evolution exhibit generate hACE2 human ACE2 in vivo K417N mACE2 Microscopy molecular basis molecular mechanism Mortality mouse-adapted SARS-CoV-2 Mutation N501Y pathogenicity Pathogens platform provide RBD RBD mutation receptor Receptor binding domain reduce respiratory respiratory symptoms reveal SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 strain Sequencing severe COVID-19 severe respiratory symptoms significantly structural biology the binding affinity the RBD virus Virus-host interactions [DOI] 10.1038/s41467-021-25903-x PMC 바로가기 [Article Type] Article
Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolatesSARS-COV-2 스파이크 당 단백질 돌연변이 체의 대규모 분석Research Article Published on 2021-09-272022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis analyzed Antibody binding approved Co-infection COVID-19 pandemic data set data sets dataset Early detection ENA European Nucleotide Archive Evolution exhibiting genome assembly GISAID glycoprotein human populations immune response immune responses increase in induce Infection less majority median mRNA vaccine mRNA vaccines mutant mutant spike protein mutants Mutation mutation rate NGS Non-synonymous mutation nucleotide reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome assembly SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 strain Spike protein strain T-cell the mean the SARS-CoV-2 genome the spike protein Therapeutic strategies variant variants Variation virus isolate widespread wild-type [DOI] 10.1371/journal.pone.0249254 PMC 바로가기 [Article Type] Research Article
Case report: change of dominant strain during dual SARS-CoV-2 infection사례보고 : 이중 SARS-COV-2 감염 동안 우세한 균주의 변화Case Reports Published on 2021-09-162022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, [키워드] Analysis Case report cause of death change clade Coronavirus infection COVID-19 COVID-19 patients death described died disease disease manifestation dominant dual Dual infection eight explained Fever Genomic analysis High-throughput sequencing hospital hospitalised ICU ICU treatment Infection infection with SARS-CoV-2 Insufflation intensive care intensive care unit nucleotide oropharyngeal swab oropharyngeal swabs oxygen Patient performed Phylogenetic positive premorbid progressed required SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain Sequencing Seven strain Strains supplementary material Swab swabs tested the patient transferred Treatment virulence worsened [DOI] 10.1186/s12879-021-06664-w PMC 바로가기 [Article Type] Case Reports