Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesisSARS-CoV-2와 인간 코로나바이러스의 상호작용은 잠재적으로 병인에 영향을 미치는 숙주 요인을 나타냅니다Article Published on 2021-09-012022-09-11 Journal: The EMBO Journal [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Affinity purification BioID2 cellular response Cellular responses comparison conducted coronavirus COVID-19 disease disease pathology drug target encoded viral proteins explain Factor Host host cell host cells host-virus protein-protein interaction human coronavirus human coronaviruses human protein human proteins Interaction interactome life cycle nsp1 Pathogenesis pathway Protein protein-protein interaction Proteins provide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus SFB-TAP survival These data these viruses treating Treatment treatment of COVID-19 valuable resource Viral proteins virus [DOI] 10.15252/embj.2021107776 PMC 바로가기 [Article Type] Article
AI-driven multiscale simulations illuminate mechanisms of SARS-CoV-2 spike dynamicsSpecial Issue Papers Published on 2021-09-012022-10-29 Journal: The International Journal of High Performance Computing Applications [Category] COVID-19, [키워드] accelerate AI Complete complex computational virology conformational COVID19 deep learning develop flexible glycan GPU heterogeneous HPC human ACE2 receptor Interaction mechanism modulating molecular molecular dynamics multiscale simulation resource SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral Spike protein Summit the SARS-CoV-2 variety viral infection virus weighted ensemble [DOI] 10.1177/10943420211006452 PMC 바로가기 [Article Type] Special Issue Papers
Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome InsightsResearch Article Published on 2021-09-012022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Alter Analysis approach average Better capture clinically coronavirus COVID-19 defined detect diagnostics DNA double-stranded drug dsDNA Emergency use authorization Evidence FDA food Genetic Genetic variant Genome highlight Hybrid capture hybridization IMPROVE Infectious disease insight limit of detection metagenomics Microbiome molecular mutations nasopharyngeal Next-generation sequencing NGS Outbreaks pathogen polymerase chain positive Precision probes reverse transcription risk stratification RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral SARS-CoV-2-positive patients Spike protein Surveillance the SARS-CoV-2 genome the SARS-CoV-2 virus therapeutic therapeutic options urgency Vaccine variants viral evolution viral fitness viral genomics widespread [DOI] 10.1128/Spectrum.00197-21 PMC 바로가기 [Article Type] Research Article
Synthesis and Biological Evaluation of Honokiol Derivatives Bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones as Potential Viral Entry Inhibitors against SARS-CoV-2Communication Published on 2021-08-312022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019 coronavirus disease ACE2 ACE2 blocker activities analogue Antiviral antiviral activity antiviral efficacy antiviral molecules Bearing bind binding binding affinity Biological Biosafety Level 3 BLI caused contribute cortex COVID-19 demonstrated derivative develop effective ELISA assay examined Health Honokiol honokiol analogues host cell human Ace2 protein inhibitor inhibitory effect lower binding energy medication molecular docking parental Potential Research SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 viral SARS-CoV-2 virus infection strain synthesis the SARS-CoV-2 virus Viral entry inhibitors [DOI] 10.3390/ph14090885 PMC 바로가기 [Article Type] Communication
CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literatureImmPort 보고서 및 문헌을 기반으로 한 COVID-19 감염에 대한 호스트 응답의 CIDO 온톨로지 업데이트 및 2차 분석Research Published on 2021-08-282022-09-10 Journal: Journal of Biomedical Semantics [Category] MERS, 변종, 유전자 메커니즘, [키워드] ACE2 added Analysis benefit binding can be used CIDO Cohort coronavirus Coronavirus infectious disease ontology coronavirus S COVID-19 COVID-19 infection COVID-19 patients cytokine Cytokines Data analysis database development enhancement epitope Epitopes female patient Female patients homology host response host responses Host-coronavirus interaction IL-10 ImmPort immune Infection information Interaction knowledge male mechanisms Metadata molecular Mortality Mutation OBO foundry Ontology overlap pandemic Patient patients performed platform recorded reinforcement reported representing Research response Result S protein S proteins SARS-CoV-2 SARS-CoV-2 viral secondary Sex difference signaling pathway statistically significant Support supported up-regulated variants viral S viral S protein was used [DOI] 10.1186/s13326-021-00250-4 PMC 바로가기 [Article Type] Research
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions생체 내 SARS-CoV-2 상호 작용의 포괄적 인 매핑은 기능적 바이러스-숙주 상호 작용을 나타냅니다Article Published on 2021-08-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] approach bind Cell cells cellular Comprehensive element epigenomics functional Genome global health Health Host host mRNA identify Illumina in viral in vivo Interaction interactions Methylation mitochondrial molecular mutant observé pathogenicity platform regions report reveal RNA RNA sequencing RNA-RNA interaction RNA-RNA interactions RNAs SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral secondary structure Sequencing small nucleolar RNA structures subgenomic RNA subgenomic RNAs targeted therapy the SARS-CoV-2 genome untranslated regions Viral viral genome virus virus genome virus infection Virus-host interaction Virus-host interactions wildtype Δ382 [DOI] 10.1038/s41467-021-25357-1 PMC 바로가기 [Article Type] Article
A glycan gate controls opening of the SARS-CoV-2 spike protein Research Published on 2021-08-192022-10-05 Journal: Nature chemistry [Category] 변종, [키워드] Activation Analysis Control Cryo-electron microscopy ectodomain evade experiments facilitate glycosylated human Angiotensin-converting enzyme infect cells Infection mechanism offer pathway Pathways provided R408 RBD receptor Receptor binding domain SARS-COV-2 infection SARS-CoV-2 viral Spike protein the SARS-CoV-2 the spike protein while [DOI] 10.1038/s41557-021-00758-3 [Article Type] Research
Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?말이 달려들기 전에 문을 닫으십시오: SARS-CoV-2와 항바이러스제 내성에 대한 대화가 필요한 시점입니까?Review Published on 2021-08-122022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] Antiviral antiviral drug antiviral therapy class COVID-19 COVID-19 treatment Critical deliberation drug drug resistance drug target Efficacy HIV Influenza Influenza virus mechanism monotherapy Mutation provide Research resistance SARS-CoV-2 SARS-CoV-2 viral stimulate Treatment Variability virus widespread [DOI] 10.1093/jac/dkab189 PMC 바로가기 [Article Type] Review
Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools컴퓨터 도구를 사용한 SARS-CoV-2 바이러스 단백질에 대한 식물 유래 화합물의 가상 스크리닝Article Published on 2021-08-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료제, [키워드] 3-chymotrypsin-like protease addition amyrin antiviral activity Atazanavir AutoDock binding Chloroquine chymotrypsin Chymotrypsin-like protease Compound computational tool Control COVID-19 COVID-19 pandemic delphinidin dicumarol docking Docking studies drug evaluate evaluated explain glycoprotein Glycyrrhetinic acid glycyrrhizin highest affinity host cell host cells hydrogen Hydrogen bond hydrophobic hydrophobic interaction hydrophobic interactions Hydroxychloroquine identify in viral inhibitor Interaction involved lowest M pro molecular molecular docking molecular target nelfinavir new SARS-CoV-2 plants protease Protein Proteins public health Recognition Replication responsible S protein SARS-CoV-2 SARS-CoV-2 viral SARS-CoV2 spike spike glycoprotein taraxasterol target umifenovir Viral protein Viral proteins viral replication viral spike virus was performed were used [DOI] 10.1016/j.scitotenv.2021.146400 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection induces beta cell transdifferentiationSARS-CoV-2 감염은 베타 세포 전환분화를 유도합니다Clinical and Translational Report Published on 2021-08-032022-09-10 Journal: Cell Metabolism [Category] MERS, SARS, 치료기술, [키워드] Abstract acinar cell addition Alpha Antigen Autopsies Autopsy beta cell Beta cells cause Cell cell fate cell markers cellular cellular stress response chemokines Clinical data coronavirus disease Coronavirus disease 2019 correlation COVID-19 diabetes EgIF2 eIF2 example expression glucagon human islets immunostaining indicated individuals with COVID-19 induce Infection inhibitor insulin islet cell ISRIB lower expression pancreatic pancreatic islet Pathomechanism Pathomechanisms pathway phenotype provide PRSS1 recent reported reversed RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Single-cell RNA sequencing Stress stress response subject subjects suggested susceptible Trajectory analysis Tran trans trypsin 1 Viral Viral antigen [DOI] 10.1016/j.cmet.2021.05.015 PMC 바로가기 [Article Type] Clinical and Translational Report