The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation스파이크 돌연변이의 출현과 성공에서 SARS-CoV-2 유전적 배경의 구조적 역할: 스파이크 A222V 돌연변이의 경우Article Published on 2022-07-112022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] A222V A222V mutation ACE2 binding characteristic clade computational studies Computational study Delta Effectiveness functional genetic background increase Mutation neutralization capacity not affect not reduce Point mutation promote question raising RBD SARS-CoV-2 SARS-CoV-2 variant sera serological Spain Vaccine viral infection [DOI] 10.1371/journal.ppat.1010631 PMC 바로가기 [Article Type] Article
Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccinesResearch article Published on 2022-07-092022-10-05 Journal: iScience [Category] 비임상, [키워드] Antigen binding collected conjugate Conjugates crosslinked demonstrated domain effective Efficacy ENhance functional generate hACE2 immunology isolate mice pandemic persist Protein Pseudovirus neutralization assays RBD SARS-CoV-2 SARS-CoV-2 vaccine sera Th1 Vaccine variant variants Virology [DOI] 10.1016/j.isci.2022.104739 [Article Type] Research article
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화Article Published on 2022-07-072022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type [DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation예방 접종 또는 감염 후 유도된 SARS-CoV-2 스파이크 및 핵단백질 특이적 항체는 고전적 보체 활성화를 촉진합니다Article Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Activation antibodies antibody Antibody responses Antigen binding C1q C1q binding C3b cascade classical classical pathway complement Complement activation Complement cascade complement components Complement pathway component components convalescent COVID-19 COVID-19 patient COVID-19 patients deposition disease status downstream Effect ELISA assay groups hospitalised IgG1 induced median N antigen NHC non-hospitalised non-infected not differ nucleocapsid presence of antibody protective role Protein Protein binding response responses SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera severe COVID-19 specific antigen spike spike glycoprotein subject the disease vaccination Vaccine vaccinees Variability Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.838780 PMC 바로가기 [Article Type] Article
Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCsSARS-CoV-2 VOCs에 대한 동종 또는 이종 감염 또는 백신 접종을 통해 유도된 항체의 중화 능력Article Published on 2022-07-042022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Alpha antibody antigenic B.1 Beta Blood blood specimens Breakthrough infection breakthrough infections Clusters Combination Combined complex convalescent individual convalescent individuals Delta determined by elicited escape Gamma homologous homologous or heterologous Immune escape Immunity Infection isolates Last lead less neutralization Neutralization assay neutralization titer Neutralizing neutralizing capacity omicron Patient population immunity question raise SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 variant SARS-CoV-2 variants sera Seven specimen vaccinated individual vaccinated individuals vaccination Vaccinations variant variants VoC Zeta [DOI] 10.1038/s41467-022-31556-1 PMC 바로가기 [Article Type] Article
Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severityCOVID-19 환자의 항-IFN-α/-ω 중화 항체는 IFN 반응의 하향조절 및 질병 중증도의 실험실 바이오마커와 상관관계가 있습니다Article Published on 2022-07-012022-09-11 Journal: European Journal of Immunology [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Antiviral association autoantibodies autoantibodies, SARS-CoV-2 binding binding antibodies binding antibody biochemical characterized COVID-19 COVID-19 patient cross-reactivity CRP D-dimer dimer disease severity downregulation fluctuation Gene Expression hematological parameters ICU IFN IFN response IFN-stimulated gene IFN-stimulated genes IFN-α interferon ISG ISGs laboratory biomarker laboratory biomarkers LDH male Neutralizing antibodies neutralizing antibody outcome Patient patients positive positive patient proportion quantified reduced respiratory Respiratory samples screened sera serum severe COVID-19 shown specificity subset tested transcript levels [DOI] 10.1002/eji.202249824 PMC 바로가기 [Article Type] Article
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination예방 접종 없이 SARS-CoV-2 Omicron에 대한 제한된 교차 변이 면역Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Activation arise Brain brains Breakthrough infection cause Cytokines Delta disease elicited ENhance expression human ACE2 receptor humans humoral immune response Immunity individual individuals induce Infection infections lead Limited lung Lung disease Lungs mice Mild Mild disease neutralization neutralize omicron other variant overexpressing pandemic pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines question reduced replicate risk SARS-CoV-2 SARS-CoV-2 delta sera Symptoms T cells titre vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern WA1 widespread [DOI] 10.1038/s41586-022-04865-0 PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 omicron BA.1 and delta AY.4.2 variants on the neutralization by sera of patients treated with different authorized monoclonal antibodiesSARS-CoV-2 omicron BA.1 및 delta AY.4.2 변이체가 다른 승인된 단일클론항체로 치료받은 환자의 혈청 중화에 미치는 영향Article Published on 2022-07-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Impact monoclonal antibody neutralization patients treated SARS-CoV-2 sera variant [DOI] 10.1016/j.cmi.2022.03.005 PMC 바로가기 [Article Type] Article
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding Research Published on 2022-07-012022-10-05 Journal: Cell Discovery [Category] 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Activation adaptive Analysis cell count Cell migration Classifier complement Course COVID-19 COVID-19 patient enhanced exhibited IgG antibody Immunity Inflammation liver longitudinal metabolites metabolomics pathway Patient predict proteomics receptor Regulatory RNA SARS-COV-2 infection sera subset suppressed the patient Treg Viral load viral replication Viral RNA Viral RNA shedding [DOI] 10.1038/s41421-022-00441-y [Article Type] Research
Neutralizing antibody response against the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants after a third mRNA SARS-CoV-2 vaccine dose in kidney transplant recipients신장 이식 수혜자에서 세 번째 mRNA SARS-CoV-2 백신 접종 후 B.1.617.2(델타) 및 B.1.1.529(오미크론) 변이체에 대한 중화 항체 반응Observational Study Published on 2022-07-012022-09-11 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] addition Anti-RBD antibodies anti-receptor-binding domain antibody antibody response against B.1.1.529 B.1.617.2 clinical decision-making Clinical research COVID-19 vaccination cross-neutralization detectable dose healthy control healthy controls IgG immune immune modulation Immunosuppression kidney kidney transplant recipient kidney transplant recipients Kidney transplantation mRNA mRNA vaccine Nephrology neutralization neutralization titer neutralization titers Neutralizing Neutralizing antibodies neutralizing antibody Observational cohort study organ organ transplantation patients Practice reduced SARS-CoV-2 SARS-CoV-2 vaccine sera Seroconversion Seropositivity significantly significantly lower solid organ solid organ transplantation the SARS-CoV-2 Vaccine vaccine dose variant variants of concern wild-type [DOI] 10.1111/ajt.17054 PMC 바로가기 [Article Type] Observational Study