Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data중증 코로나19 폐렴: 이중 에너지 CT 데이터를 이용한 폐색전증 및 혈관 비대와의 상관관계 관류 분석Research Article Published on 2021-06-082022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] 8 women age Analysis analyzed Applying Cohort consecutive patient consolidation consolidations correlated correlation COVID-19 COVID-19 pneumonia demonstrated determine GGO help hypo Iodine lung marker men objective pathophysiology Patient Perfusion Pneumonia predominant Pulmonary embolism Result Severe COVID-19 pneumonia significantly significantly higher statistical analyses subset therapy upstream vessel was measured were used women [DOI] 10.1371/journal.pone.0252478 PMC 바로가기 [Article Type] Research Article
Feasibility of sit training for patients with severe COVID-19 pneumonia during deep sedation A case report6300 Published on 2021-06-042022-10-30 Journal: Medicine [Category] COVID-19, MERS, SARS, [키워드] Admission adverse event Blood blood pressure Case report coronavirus disease COVID-19 decrease Diabetes Mellitus diagnosed died disease Early Ambulation early rehabilitation Effectiveness Effects hospital Hypoxemia indicate initial lacunar infarction Local mechanical ventilation medication muscle relaxation PaCO2 paO2/fiO2 Patient physical Pneumonia polymerase chain rehabilitation Sedation Serious Adverse Event severe acute respiratory syndrome coronavirus 2 Severe COVID-19 pneumonia sitting position sputum subsequent suction the patient transfer transferred ventilator worsening respiratory status [DOI] 10.1097/MD.0000000000026240 PMC 바로가기 [Article Type] 6300
The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumoniaShort Report Published on 2021-06-022022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] accompanied addition assays baseline bronchoalveolar cellular chemokine circulating circulating monocyte Coronavirus disease 2019 COVID-19 Cytokines decrease effective ELISA Exploratory analysis flow cytometry functional immune modulatory effect immune reaction immunological immunomodulatory property immunosuppressive Infection Inflammatory inflammatory neutrophils Inflammatory response intensive care unit interleukin-6 life-threatening low-density Mesenchymal stromal cells MSC MSCs myeloid cells neutrophil neutrophil recruitment Patient Peripheral blood plasma Pneumonia pro-inflammatory cytokines pro-thrombotic reduction renal scRNA-seq Serum level severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA sequencing stromal cell supplementary material T lymphocyte treated Treatment Trial tumor necrosis factor-α umbilical were assessed [DOI] 10.1186/s13287-021-02376-9 PMC 바로가기 [Article Type] Short Report
Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current PandemicReview Published on 2021-06-012022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ARDS coronavirus COVID-19 COVID-19 pandemic current effective vaccine iatrogenic identify ILD imaging abnormality Immune-mediated implicated increased risk increasingly initial Interstitial lung disease Lung injury mechanical ventilation mechanism morbidity and mortality novel novel coronavirus SARS-CoV-2 outbreak pathophysiology Patient Pneumonia progression pulmonary pulmonary fibrosis reducing respiratory complication risk risk factor SARS-CoV-2 Severe COVID-19 Infection Severe COVID-19 pneumonia severe disease Treatment vascular disease Venous Thromboembolism [DOI] 10.3390/jcm10112452 PMC 바로가기 [Article Type] Review
Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trialResearch article Published on 2021-06-012022-10-05 Journal: The Lancet Rheumatology [Category] 임상, [키워드] 1:1 adverse event analysed assigned benefit C-reactive protein concentration colony stimulating factor Confidence intervals COVID-19 death deaths double-blind enrolled enrolment evaluate finding funding GM-CSF groups hospital hospitalisation hypoxaemia IMPROVE Inflammatory response initiated intention-to-treat population investigator investigator-initiated mechanical ventilation monoclonal antibody multicentre nine no significant difference Odds ratio outcome Oxygen therapy participant Patient patient population patients with COVID-19 Placebo placebo-controlled trial Pneumonia Potential treatment primary endpoint Primary outcome proportion randomised Randomised trial Randomly receive receptor Registered required Research Respiratory failure Seven Severe COVID-19 pneumonia single intravenous infusion Stratification Supplemental oxygen therapy systemic hyperinflammation the placebo group therapy Treatment Trial USA was done were excluded [DOI] 10.1016/S2665-9913(21)00070-9 [Article Type] Research article
Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study중증 COVID-19 폐렴 및 중등도 과염증 환자에서 코르티코스테로이드 단독 또는 토실리주맙 치료 후 아나킨라. 후향적 코호트 연구Observational Study Published on 2021-06-012022-09-12 Journal: Internal and Emergency Medicine [Category] MERS, 임상, 진단, [키워드] 95% CI according to protocol adjusted hazard ratio Admission age Anakinra analyzed appear carried CD4 Characteristics clinical Clinical course Clinical severity Corticosteroid corticosteroid pulse COVID-19 Cytokine storm syndrome death died Evidence hyperinflammation hyperinflammatory state IMPROVE infectious complication Infectious complications intensive care Laboratory management Methylprednisolone moderate Mortality Observational cohort study Patient patients with moderate Prognosis pulse receiving receptor reduced risk retrospective retrospective cohort study Severe COVID-19 pneumonia Standard therapy Tocilizumab tocilizumab therapy Treatment treatment with anakinra [DOI] 10.1007/s11739-020-02600-z PMC 바로가기 [Article Type] Observational Study
Clinical Characteristics and Early Interventional Responses in Patients with Severe COVID-19 PneumoniaResearch Article Published on 2021-05-312022-10-31 Journal: Computational and Mathematical Methods in Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome age ARDS bilateral pneumonia caused center characteristics of patient Chest computerized tomography China claimed clinical clinical feature clinical manifestations Clinical outcome collected Combination combined treatment coronavirus coronavirus disease-2019 COVID-19 COVID-19 patients death demographic demonstrated dry cough Dyspnea early diagnosis effective effective therapy electronic medical records elevated fatigue Fever Hospitalized human immunoglobulin IL-10 IMPROVE Infection inflammatory reaction Inflammatory response interquartile range Intervention Laboratory male measure Methylprednisolone objective Patient patients Pneumonia Prognosis Progressive Public radiological response Result Severe COVID-19 pneumonia syndrome Treatment Zhejiang [DOI] 10.1155/2021/6676987 PMC 바로가기 [Article Type] Research Article
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 PneumoniaCOVID-19 폐렴이 있는 흡연자의 폐 조직에서 안지오텐신 전환 효소 2 수용체의 낮은 유전자 발현Article Published on 2021-05-262022-09-01 Journal: Biomolecules [Category] SARS, 진단, [키워드] ACE-2 acute respiratory syndrome age angiotensin Angiotensin converting enzyme receptor Angiotensin-converting enzyme aspect Autopsies Bayesian biological interaction case sery cell entry receptor Chain Reaction complex concerning coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia Critical enzyme evaluated expression expressor focus Gender Gene Expression hypertension Infection less Lower lung lung tissue lung tissue sample lung tissue samples mRNA expression observational study polymerase chain polymerase chain reaction prevalent real-time polymerase chain reaction respiratory retrospective risk factor SARS-CoV-2 SARS-CoV-2 genome Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Severe COVID-19 pneumonia smoker Smokers smoking susceptibility susceptibility to infection translational Vascular injury Viral virus with COVID-19 [DOI] 10.3390/biom11060796 PMC 바로가기 [Article Type] Article
Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia코비드-19 폐렴에 대한 덱사메타손 대 메틸프레드니솔론 고용량Randomized Controlled Trial Published on 2021-05-252022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 임상, [키워드] acute respiratory syndrome Administered alveolar pressure Ambispective cohort study Analysis applied ARDS Berlin protocol C-reactive protein calculated can be used carried Chain Reaction Chest Chest tomography clinic Clinical outcome completion coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 pneumonia CRP D-dimer decrease Dexamethasone dexamethasone 6 mg DHL diagnosed discharge dose DXM effective therapy evaluated Follow-up followed by ground-glass imaging High dose high-complexity clinic high-dose methylprednisolone Hospitalization Hospitalized hospitalized patient hospitalized patients inclusion criteria Infectious disease Infectious diseases inspired oxygen fraction institutional protocol intensive care intensive care unit intravenous Invasive mechanical ventilation Laboratory laboratory result Laboratory results LDH less living-dead status marker material Medellín, Colombia Methylprednisolone Mortality MTP group Not applied optimal dose outpatient consultation oxygen P-value PaFi Patient patients treated Pneumonia polymerase chain polymerase chain reaction Prednisone proportion prospective cohort protocol Pulmonology radiological Randomized controlled studies readmission Recovery time required responsible Result Sample Sample size SARS-CoV2 Seven Severe acute respiratory syndrome severe ARDS Severe COVID-19 pneumonia severe SARS severity shown significantly statistically subsequent supplementary oxygen survival survival analysis telephone the patient tomography total population transfer treated Treatment [DOI] 10.1371/journal.pone.0252057 PMC 바로가기 [Article Type] Randomized Controlled Trial
High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumoniaArticle Published on 2021-05-242022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, [키워드] acute phase response Analysis association body mass index C-reactive protein Comorbidity Concentration concentrations correlated COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients Cytokines dysregulated immune response enrolled Fatty acid feature form HDL High-density lipoprotein cholesterol hospitalized patient Immunopathogenesis Infection initial intensive care lipoprotein metabolism metabolic disorder MOST NEFA Non-COVID-19 obese patients Organ failure outcome Pathogenesis patients hospitalized plasma plasma concentration Pneumonia Polyunsaturated PUFA required respiratory severity Sepsis Severe COVID-19 pneumonia severe pneumonia SOFA therapeutic targets to define unique Ventilator-free days were assessed with COVID-19 [DOI] 10.1038/s41598-021-90362-9 PMC 바로가기 [Article Type] Article