Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: results from a nationwide online surveyResearch Article Published on 2020-07-132022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] activity Analysis burden Care COVID-19 COVID-19 pandemic East equipment evaluated female participant Germany Health healthcare Healthcare workers hospital majority measure Nurse Nurses participant participated Perception Personal protective equipment positive PPE preventive measure professional professionals Protective reported SARS-CoV-2 pandemic significantly starting point supported while [DOI] 10.1080/22221751.2020.1785951 PMC 바로가기 [Article Type] Research Article
High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2Article Published on 2020-07-132022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] 3CL pro acute respiratory syndrome amino acid residues approved drugs bind binding catalytic dyad characterized Compound compounds computer-aided drug design coronavirus COVID-19 demonstrated docking Drug repurposing drugs enzyme functional group Hormones Hydrogen bond identify in silico drug design in vitro include inhibitor inhibitors inhibitors of SARS-CoV-2 inhibitory activity Ligand monocyclic natural products protease protocol Replication reported residue SARS-CoV virus SARS-CoV-2 Screening severity of COVID-19 starting point the SARS-CoV-2 throughput tyrosine kinase inhibitors viral replication inhibition [DOI] 10.3390/molecules25143193 PMC 바로가기 [Article Type] Article
Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling studyArticle Published on 2020-06-152022-10-30 Journal: The Lancet. Global health [Category] COVID-19, Fulltext, MERS, [키워드] African age agency analysed assumed burden calculated cardiovascular disease China Chronic kidney disease chronic respiratory disease Clustering condition conditions confidence limit country COVID-19 defined Department determine development diabete diabetes disease estimate Factor female females finding FIVE Fractions frailty funding global pandemic groups Health health condition help high risk highest HIV/AIDS Hospital admission increased risk individual Interpretation interval male Medical Research Council Multimorbidity National obesity Older populations Prevalence prevalences public health risk risk factor severe COVID-19 severe disease Sex Socioeconomic deprivation starting point underlying condition understanding USA vaccinate was determined Wellcome Trust WHO [DOI] 10.1016/S2214-109X(20)30264-3 PMC 바로가기 [Article Type] Article
COVID-19 Pandemic and Telephone Triage before Attending Medical Office: Problem or Opportunity?Editorial Published on 2020-05-202022-10-30 Journal: Medicina [Category] Coronavirus, MERS, SARS, [키워드] Attending clinician Community Contamination COVID-19 COVID-19 emergency COVID-19 epidemic Diagnosis Effectiveness Epidemiology infection risk management manuscript Patient Perspective Prevent problem protocol reducing risk Safe starting point Telemedicine telephone the patient Triage virus [DOI] 10.3390/medicina56050250 PMC 바로가기 [Article Type] Editorial
School closure in response to epidemic outbreaks: Systems-based logic model of downstream impactsResearch Article Published on 2020-05-122022-10-31 Journal: F1000Research [Category] Coronavirus, MERS, SARS, [키워드] 2019 novel coronavirus children children’s health coding conceptual framework Contact COVID-19 develop downstream Epidemic Epidemics epidemiological Evidence synthesis Factor Factors Frame Health help highlight Impact impacts Infection Intervention literature logic model Novel coronavirus pandemic parent public health reduce Research School school closure Seven starting point Transmission unmet need while [DOI] 10.12688/f1000research.23631.1 PMC 바로가기 [Article Type] Research Article
Conversations and Medical News Frames on Twitter: Infodemiological Study on COVID-19 in South KoreaOriginal Paper Published on 2020-05-052022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] 95% CI aggregation Analysis applied article assist China collected complex conducted Conversation coronavirus coronavirus disease COVID-19 effective faster Final Frame function greater groups Health highlighting individual Infectious disease infodemiology information initial Korean media medical news MOST network analysis New objective outbreak pandemic positive professional public health real time Research Respiratory Coronavirus Result SARS-CoV-2 significant difference social media South Korea Spread starting point Transmission Twitter [DOI] 10.2196/18897 PMC 바로가기 [Article Type] Original Paper
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labelingResearch Article Published on 2019-01-112022-10-31 Journal: eLife [Category] Coronavirus, MERS, [키워드] assist Biotin breadth build caused Cell common cold Complete complex complexes comprehensive analysis Contact Coronaviral coronavirus Coronaviruses Critical cytoplasm demonstrated Determination disease enzyme Factor Factors genetic code help Host host cell host cells host protein host proteins Human infect Infection infections Interaction involved kill knowledge membrane MERS microenvironment Mild molecular mouse nose and throat Other Pathways platform positive-sense RNA virus Protein proximal proximity labeling question replicase complex replication complex researcher RNA virus RTC scientist severe disease short-lived starting point Symptom target therapeutic intervention These viruses translation translation initiation Transport turn Vesicular Transport Viral proteins viral RNA synthesis virus virus infection virus particles Virus-host interaction waste disposal [DOI] 10.7554/eLife.42037 PMC 바로가기 [Article Type] Research Article
High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines고해상도 유전학, 지질 전달 단백질 Sec14p를 항진균성 에르골린의 표적으로 식별Research Article Published on 2016-11-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] analogue analogues Antibiotics Antifungal binding pocket clinic Compound Cryptococcus neoforman Cryptococcus neoformans death determinant develop disease Diseases dual Efficacy and safety ergoline ergolines Evidence fluconazole fungal fungal pathogen fungal pathogens fungi fungicidal activity Genetic genetic evidence growth homolog implicated Infection Infectious diseases inhibit inhibiting initial Interaction involved isolate knowledge Lipid malaria mammalian cells Medicines Mutation pathogenic pathogenicity Pathogens Protein resistance to antibiotics secretion selectivity significantly starting point target therapy transfer variety viability virulence was used [DOI] 10.1371/journal.pgen.1006374 PMC 바로가기 [Article Type] Research Article