Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in ChinaOriginal Article Published on 2016-11-092022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] antibody Antibody titer Antigen characterization China correlated correlation domain ELISA ELISAs enzyme-linked immunosorbent enzyme-linked immunosorbent assay Extracellular inactivated Infection MERS MERS coronavirus MERS-CoV Middle East N-terminal domain neutralization neutralizing antibody NTD occurred Patient pseudovirus RBD RBD ELISA recombinant structural antigens sera Seroconversion significantly Strong syndrome the patient [DOI] 10.1038/emi.2016.114 PMC 바로가기 [Article Type] Original Article
Strong Selection at MHC in Mexicans since Admixture혼합 이후 멕시코의 MHC에서 강력한 선택Research Article Published on 2016-02-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence admixture African allele Analysis average coefficient Cohort credibility datasets dbGaP debate detect deviate difficulty European Europeans flexibility genetic difference Genome Genome-wide association study hallmark Haplotype humans inaccuracy Latino Local medical history Mexican Mexicans MHC performed populations Region reported Selection significantly statistical model Strong subject Taking the strongest [DOI] 10.1371/journal.pgen.1005847 PMC 바로가기 [Article Type] Research Article
A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and VaccinesResearch Article Published on 2013-12-042022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cells bind binding block caused culture supernatant Developing development Dipeptidyl peptidase 4 domain DPP4 effective eight expressed fused high mortality IgG Fc induce inhibited MERS MERS-CoV MERS-CoV infection mice Middle East neutralize Novel coronavirus Protein purified RBD RBD protein receptor reported residue respiratory infectious disease S-specific antibodies Safe Saudi Arabia spike Spread spread to Strong syndrome therapeutic Therapeutics Vaccine [DOI] 10.1371/journal.pone.0081587 PMC 바로가기 [Article Type] Research Article
Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: Implications for the diagnosis of coronavirus infectionArticle Published on 2012-11-192022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] Adults antibody Antigen antigenicity Betacoronavirus Blood blood sample C-terminal domain characterisation Coronavirus infection cross-react demonstrated detected antibody Diagnosis diagnostic different E, Envelope Elderly patient epidemiological evaluated greater HCoV-229E HCoV-OC43 HCoV-OC43, human coronavirus OC43 Human coronavirus human coronavirus OC43 human CoV human serum humans identify immune response immunoreactivity Infection IPTG, β-d-1-thiogalactopyranoside M, matrix N-terminal domain NP, nucleocapsid protein nucleocapsid protein OC43 strain occur offer patients polyclonal polyclonal antibody previous study produced Protein purified rabbit polyclonal antibody reactivity Region reported respiratory infection RNP, ribonucleoprotein S, spike SARS-CoV serum serum sample specificity SPR, surface plasmon resonance Strong tested Variability virus infection [DOI] 10.1016/j.jviromet.2012.11.009 PMC 바로가기 [Article Type] Article