translational – Page 12 – Communicable Diseases Research

Women and babies are dying from inertia: a collaborative framework for obstetrical drug development is urgently needed

Research article

Published on 2021-07-012022-10-05
Journal: American journal of obstetrics and gynecology [Category] 비임상,

Reimagining the peer-review system for translational health science journals

중개적 건강 과학 저널을 위한 피어 리뷰 시스템 재구상

Review

Published on 2021-07-012022-09-11
Journal: Clinical and translational science [Category] SARS, 임상,

Does Covera-19 know ‘when to hold ‘em or ‘when to fold ‘em? A translational thought experiment

Review

Published on 2021-06-302022-10-29
Journal: Translational Medicine Communications [Category] COVID-19,

[키워드] Acidic amino acid sequence change changes conformational change COVID-19 Effect electrical experiment Extracellular function furin histidine Host human host induce Protein receptor Repurposed drug Research SARS-CoV-2 survival thought translational Treatment
[DOI] 10.1186/s41231-021-00090-5 PMC 바로가기 [Article Type] Review

Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS‐CoV‐2

생체 내에서 ACE2 발현의 분자 PET/CT 프로파일 링 : SARS -COV -2의 감염 및 결과에 대한 시사점

Research Article

Published on 2021-06-262022-09-01
Journal: Advanced Science [Category] MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin‐converting enzyme 2 animal model approach binding causative agent clinical evaluation coronavirus disease Coronavirus disease 2019 COVID‐19 Critical determine disease entry receptor enzyme evaluated facilitate healthy volunteer healthy volunteers high affinity Human identify impacted IMPROVE in vitro infect cell infect cells infection process key factor model systems molecular molecular imaging MONITOR organ organs Patient peptide PET/CT positron emission Positron emission tomography positron emission tomography imaging Profiling provide Quantitative quantitative determination question radiolabeled Rapid receptor reported reproductive reproductive system Research respiratory SARS‐CoV‐2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus‐2 severity subject susceptible the patient tissue tomography translational Translational research unique whole body
[DOI] 10.1002/advs.202100965 PMC 바로가기 [Article Type] Research Article

Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer

Article

Published on 2021-06-212022-10-04
Journal: Cell Death & Disease [Category] 바이오마커,

COVID-19: Sleep, Circadian Rhythms and Immunity – Repurposing Drugs and Chronotherapeutics for SARS-CoV-2

Neuroscience

Published on 2021-06-182022-10-31
Journal: Frontiers in Neuroscience [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory syndrome Affect affected ARDS Cardiopulmonary caused chronic pulmonary disease chronotherapy circadian clock circadian rhythms clinician Combination Comorbidity Complication contribute coronavirus Coronavirus disease-19 COVID-19 Critical current death drug dysfunction dysregulation Elderly patient Evidence FIVE globe Healthcare professional immune response Immune status Immunity IMPROVE increased mortality individual Infectious disease management mechanism modulating Mouse models multi-organ failure Novel coronavirus Older organ organs pandemic patients with SARS-CoV-2 physiological function recent finding repurposing researcher respiratory infection rhythm SARS-CoV-2 SARS-COV-2 infection Sleep syndrome the United State Therapies translational Treatment
[DOI] 10.3389/fnins.2021.674204 PMC 바로가기 [Article Type] Neuroscience

Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

전개된 단백질 반응의 조작: 코로나바이러스 감염에 대한 약리학적 전략

Research Article

Published on 2021-06-172022-09-10
Journal: PLoS Pathogens [Category] 진단, 치료제,

[키워드] activate activated Activation antiviral target ATF6 Betacoronavirus Betacoronavirus genus Cancer cellular cellular response chronic respiratory disease composed coronavirus Coronavirus infection Coronavirus replication COVID-19 COVID-19 pandemic develop died Diseases drug Endoplasmic reticulum ENhance fold genetic information highlight human lung cells in some induce infected cells Infection inhibited inhibitor manipulation medication MHV Mild mild to moderate moderate Modification MOST murine hepatitis virus neurodegenerative disorder neurodegenerative disorders Novel coronavirus Older ORF8 over-expression pathway pharmacological problem Protein protein levels reduce reduced reducing replicate Replication respiratory Respiratory disease Respiratory illness responsible RNA sequencing S protein S proteins SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cells significantly the Betacoronavirus the SARS-CoV-2 these compound these compounds These data transcriptional translational Treatment triggered unfolded protein response up-regulated UPR viral disease Viral protein Viral proteins virion virus
[DOI] 10.1371/journal.ppat.1009644 PMC 바로가기 [Article Type] Research Article

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

SARS-CoV-2 NSP14 단백질에 의한 타고난 면역 반응의 번역 차단 및 회피

423

Published on 2021-06-152022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘,

[키워드] active site active sites activities acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral antiviral proteins antiviral response causative agent caused complex conserved coronavirus COVID-19 COVID-19 pandemic Critical demonstrated ENhance evade ExoN Exoribonuclease Health Health crisis Host host antiviral responses Host immune response host immune responses host protein human coronaviruses IFN-I IFN-I responses immune evasion immune responses Infection inhibit inhibition activity inhibitor inhibitory innate immune response Innate immunity interferon interferon-stimulated gene interferon-stimulated genes ISGs mechanism nsp14 overcome Pathogenesis pathogenesis of SARS-CoV-2 pathogenic virus pathogenic viruses Pathogens previous study Protein Proteins replicate required respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance subversion synthesis the SARS-CoV-2 translation translation inhibition translational type I interferon Viral viral pathogens virus replication viruses
[DOI] 10.1073/pnas.2101161118 PMC 바로가기 [Article Type] 423

A compendium of community engagement responses to the COVID-19 pandemic

Research Article

Published on 2021-06-142022-10-30
Journal: Journal of Clinical and Translational Science [Category] COVID-19,

Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

Review

Published on 2021-06-082022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,