Estimating the asymptomatic proportion of SARS-CoV-2 infection in the general population: Analysis of nationwide serosurvey data in the Netherlands일반 인구에서 SARS-CoV-2 감염의 무증상 비율 추정: 네덜란드의 전국 혈청 조사 데이터 분석Covid-19 Published on 2021-06-102022-09-10 Journal: European Journal of Epidemiology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 95% CI age approach Asymptomatic Asymptomatic disease attributable risk calculated caused conducted containment strategies COVID-19 COVID-19 symptoms ECDC ENhance estimate implementation infected with SARS-CoV-2 Infection Netherland Netherlands open positive proportion public health Relative risk reported symptom reported symptoms Research Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive person serological Seropositivity Serosurvey supplementary material Symptom test results The Netherlands Virological was used without symptom [DOI] 10.1007/s10654-021-00768-y PMC 바로가기 [Article Type] Covid-19
The Effect of Test Timing on the Probability of Positive SARS-CoV-2 Swab Test Results: Mixed Model ApproachSARS-CoV-2 면봉 검사 결과 양성 확률에 대한 검사 시기의 영향: 혼합 모델 접근 방식Original Paper Published on 2021-06-032022-09-12 Journal: JMIR Public Health and Surveillance [Category] MERS, SARS, 진단, [키워드] age Asymptomatic asymptomatic individual change changes in close contact conducted Contact tracing COVID-19 COVID-19 pandemic early diagnosis Effect effective Evidence false-negative Final Health Health care worker health care workers Health surveillance increase individual Infection initial interval intervals Model no difference not different objective outcomes patient with COVID-19 peaked peaking positive positive test result Probability repeated Result SARS-CoV-2 SARS-CoV-2 swab Sex subset Surveillance Swab test swab test timing Symptoms Test tested time intervals university Verona Virological was used [DOI] 10.2196/27189 PMC 바로가기 [Article Type] Original Paper
Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection중증 SARS-CoV-2 감염으로 입원한 환자에서 회복기 혈장의 강력한 중화항체 효과Randomized Controlled Trial Published on 2021-05-272022-08-13 Journal: Nature Communications [Category] SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] approach autologous humoral response benefit clinical benefit comparable convalescent plasma Course COVID-19 COVID-19 patient COVID-19 patients Cytokines decision disease course donors drug Effect ENhance focus Hospital admission hospitalized COVID-19 patient Immunological response IMPROVE Infection majority neutralizing antibody neutralizing SARS-CoV-2 antibodies neutralizing SARS-CoV-2 antibody no effect Patient patients hospitalized plasma proinflammatory cytokines randomized clinical trial respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection selected serum proinflammatory cytokine serum proinflammatory cytokines severe SARS-CoV-2 standard care survival the disease translational Translational research treat treated Treatment treatment for COVID-19 Trial Viral viral clearance viral infection Virological virological and immunological responses [DOI] 10.1038/s41467-021-23469-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
The socio-spatial determinants of COVID-19 diffusion: the impact of globalisation, settlement characteristics and populationResearch Published on 2021-05-202022-11-01 Journal: Globalization and Health [Category] COVID-19, [키워드] absence anticipated Characteristics coronavirus country COVID-19 COVID-19 case COVID-19 diffusion COVID-19 transmission Defense determinant diffusion disease driver epidemiological explain Exploratory analysis global pandemic Globalisation greater Hierarchical household size Human Development Impact Infectious disease Interaction Johns Hopkins University knowledge limitations Model Older outcome population density populations predict predictor quantile regression regions Regression model replicated reported Repository Research Result Spatial diffusion Spread supplementary material sustained total population urbanisation vaccination variable Virological while widespread [DOI] 10.1186/s12992-021-00707-2 PMC 바로가기 [Article Type] Research
Diverse functional autoantibodies in patients with COVID-19 Research Published on 2021-05-192022-10-05 Journal: Nature [Category] 치료기술, 치료법, [키워드] Analysis Antigen association asymptomatic infection autoantibody characterized chemokines Clinical characteristics clinical outcomes clinical phenotype Cohort complement component COVID-19 Cytokines Disease progression disease severity Effect Extracellular functional healthcare worker Host immune Immune cell immune function immunomodulatory impair increases in individual individuals infected with SARS-CoV-2 inhibiting innate immune activation less pathological role patients with COVID-19 Prevalence Protein Proteins reactivity SARS-COV-2 infection secreted protein uninfected Virological with mild disease [DOI] 10.1038/s41586-021-03631-y [Article Type] Research
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patientsArticle Published on 2021-05-112022-10-04 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, [키워드] activated Activation Adaptive immune response antibody antibody-secreting cell B-cell CD4 CD8 Cell cellular cellular immunity characterisation circulating Cohort cytokine disease Diseases Factors follicular Genetic hospitalized patient immune immune responses immunological parameter increases in Infection infections Influenza influenza infection Influenza virus investigated memory B-cell number parameters Patient patients hospitalized phenotype real time responses severity T cell Translational immunology viral infection Virological [DOI] 10.1038/s41467-021-23018-x PMC 바로가기 [Article Type] Article
Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens표적 항원에 따른 SARS-CoV-2 감염에 대한 반응의 IgM-IgG 패턴의 바이러스학적 상관관계Article Published on 2021-05-102022-09-01 Journal: Viruses [Category] 진단, 치료법, 치료제, [키워드] amplification asymptomatic subjects characterization chemiluminescence clinical settings comparable COVID-19 determined by examined Frequency IgM IgM/IgG individual lateral flow nucleocapsid pattern positive proportion reactivity respiratory response SARS-CoV-2 SARS-CoV-2 antigen secretion serology spike subject targeting total population Viral viral shedding Virological was determined [DOI] 10.3390/v13050874 PMC 바로가기 [Article Type] Article
Neurological pathogenesis of SARS-CoV-2 (COVID-19): from virological features to clinical symptomsReview Published on 2021-05-072022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] Case report cause Central nervous system clinical manifestation clinical symptom CNS Coronavirus (CoV) coronavirus disease COVID-19 disorders feature Neural disorder outbreak pathogenesis of SARS-CoV-2 Research respiratory disorder SARS-CoV-2 thrombosis Virological [DOI] 10.1186/s41232-021-00165-8 PMC 바로가기 [Article Type] Review
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software