Drug repurposing for identification of potential spike inhibitors for SARS-CoV-2 using molecular docking and molecular dynamics simulations분자 도킹 및 분자 역학 시뮬레이션을 사용하여 SARS-CoV-2에 대한 잠재적 스파이크 억제제 식별을 위한 약물 용도 변경Article Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] ACE2 ACE2 receptor ADME administration Analysis angiotensin antiviral drugs approved drug Asthma average binding binding affinity candidate carried Compound COVID-19 COVID-19 pandemic COVID-19 treatment death develop docking drug Drug repurposing Efficacy estimates FIVE followed by free energy Hepatitis hepatitis C host cell hosts human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 identify Immunocompromised in silico Approach in vitro in vivo inhibitor Interaction leukotriene leukotriene receptor antagonist Ligand Lineage lineages membrane-bound molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Multiple Multiple studies oral administration parameter plethora Protease inhibitor receptor antagonist recognize SARS-CoV-2 SARS-CoV-2 virus SARS‐CoV‐2 selected Simeprevir Spike protein Spike proteins tested the SARS-CoV-2 virus therapeutic treat Treatment variety virus WHO Zafirlukast [DOI] 10.1016/j.ymeth.2022.02.004 PMC 바로가기 [Article Type] Article
Recent highlights on Omicron as a new SARS-COVID-19 variant: evolution, genetic mutation, and future perspectives새로운 SARS-COVID-19 변종으로서 Omicron에 대한 최근 하이라이트: 진화, 유전적 돌연변이 및 미래 전망Review Published on 2022-07-012022-09-11 Journal: Journal of drug targeting [Category] COVID19(2023년), SARS, 변종, [키워드] affected article causative agent cellular COVID-19 COVID-19 infection deaths disease event Evolution fatality Genetic Hesitancy highlight implementation individual Infection mass vaccination Mutation neutralising ability occurred omicron outbreak overcome Perspective Prevent public health measure public health measures raised recent reported SARS-COVID 19 Spread Symptoms Treatment vaccination variant virus VOCs WHO [DOI] 10.1080/1061186X.2022.2056187 PMC 바로가기 [Article Type] Review
The COVID-19 pandemic – How many times were we warned before?Review article Published on 2022-07-012022-10-05 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome caused consequence coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 pandemic disease Diseases emerging disease Epidemics evaluate indicated MERS MERS-CoV Middle East outbreak Outbreaks pandemic of COVID-19 Pandemics pathogen predicted researcher respiratory syndrome coronavirus SARS SARS-CoV SARS-CoV-2 Taking the WHO while WHO World Health Organization [DOI] 10.1016/j.ejim.2022.07.009 [Article Type] Review article
Immune-based therapeutic approaches in COVID-19COVID-19의 면역 기반 치료 접근법Review Published on 2022-07-012022-09-12 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome antibodies approach ARDS caused Complication coronavirus Coronavirus disease 2019 Coronavirus-2 Corticosteroids COVID-19 COVID-19 pathogenesis COVID-19 research Cytokine storm syndrome eliminating Epidemic immune immune system Immunotherapy interferon Intravenous immunoglobulin IVIG measure monoclonal antibody not applicable pandemic pathogen physical Pneumonia SARS SARS-CoV-2 social distancing the Coronaviridae the disease Therapeutic approach therapy Treatment vaccination viral disease WHO World Health Organization [DOI] 10.1016/j.biopha.2022.113107 PMC 바로가기 [Article Type] Review
MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative reviewReview article Published on 2022-07-012022-10-05 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료제, [키워드] ACE2 ACE2 receptor ACE2 receptors Antiviral biogenesis cellular miRNAs change chemokines collected complex conducted consequence COVID-19 cytokine Cytokines database Degradation Deleterious effective evaluate expression Extensive function generate Google help host response immune system include Infection infection process information inhibiting Interaction involved latency microRNA miRNA miRNAs Modification modulate Pathogenesis platform potential therapeutic target Prognosis reduce reduced regimen Regulation Regulatory Result SARS-CoV-2 SARS-COV-2 infection Science Direct Scientific community secretion Side effects Specific the SARS-CoV-2 therapeutic therapeutic target therapeutic targets Therapeutics therapy threat viral infection Viral load viral replication Viral RNA virus website WHO [DOI] 10.1016/j.jiph.2022.06.012 [Article Type] Review article
Characteristics and mortality of 561,379 hospitalized COVID-19 patients in Germany until December 2021 based on real-life data Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] accompanied Admission admitted to ICU analyzed arrhythmia cardiac characterising characterized COVID-19 patient death Germany heart failure high mortality higher risk hospital Hospitalized hospitalized COVID-19 patient ICU intensive care lack Mortality mortality rate non-ICU patients obesity Older outcome Patient patient cohort patient survival peaked protective effect renal SARS-CoV-2 pandemic shown treated WHO with COVID-19 [DOI] 10.1038/s41598-022-15287-3 [Article Type] Research
Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela베네수엘라에서 SARS-CoV-2에 대한 관심 및 우려의 변종에 대한 1년 연속 설명Article Published on 2022-06-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha VOC antibody Antibody-mediated neutralization circulating Complete concern correlation country COVID-19 Delta Delta VOC description dissemination Frequency Gamma Genome sequencing genomic interest Lambda less Lineage lineages low frequency MONITOR Mutation mutations neutralization New coronavirus omicron predominant Rapid screening responsible SARS-CoV-2 sequenced Transmissibility variant variants variants of concern Venezuela VoC VOCs VOI VOIs WHO [DOI] 10.3390/v14071378 PMC 바로가기 [Article Type] Article
Ivermectin for preventing and treating COVID-19COVID-19 예방 및 치료를 위한 이버멕틴Review Published on 2022-06-212022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission adverse event adverse events all-cause mortality antiparasitic Antiviral approach ARMS Asymptomatic certainty certainty of evidence citation classification Clinical improvement clinical trial Cochrane COVID-19 Study Register coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 symptoms COVID-19 treatment Data collection database death discharged disease disease severity double-blind duration of symptom early stage early stages Efficacy Efficacy and safety eligible Evidence excluded for inclusion GRADE hospital identify in vitro include increase index Infection infection with SARS-CoV-2 inhibit inhibitory effect initial symptom Inpatient Inpatients Intervention Invasive mechanical ventilation investigated Ivermectin life mean difference Mental Meta-analysis Mild Moderate COVID-19 moderate-to-severe COVID-19 molecular hypothesis Mortality no effect non-randomized ongoing trial ongoing trials Open-label outcome Outpatient outpatients participant Participants people with COVID-19 physical Placebo placebo-controlled Postexposure Prophylaxis Prevent Quality of life question Randomized controlled trial Randomized controlled trials RCT RCTs receiving reduce Registered Replication Reporting request Research resolved risk Risk of bias risk ratio RoB 2 SARS-CoV-2 SARS-COV-2 infection Science Citation Index searched Selection Serious Adverse Event Serious Adverse Events Seven severe acute respiratory syndrome Coronavirus Standard of care treat treated treating COVID-19 Treatment Trial trials viral clearance virus Web of Science WHO WHO guideline worsening [DOI] 10.1002/14651858.CD015017.pub3 PMC 바로가기 [Article Type] Review
LUNG ULTRASOUND IN OUTPATIENTS WITH COVID-19 INFECTION ASSOCIATED PNEUMONIAConference abstract Published on 2022-06-202022-10-05 Journal: Ultrasound in medicine & biology [Category] 진단, [키워드] 95% CI abnormality Accuracy Analysis blinded calculated chronic heart failure computer tomography correlated COVID-19 COVID-19 infection CT scan cut-off diagnosing Diagnosis diagnostic Diagnostic Criteria disease evaluate examined False positive feature Infection interstitial Interstitial lung disease lung Lung ultrasound material median men Mild moderate nasopharynx objective Outpatient parenchymal consolidation Patient patients Pneumonia point-of-care ultrasonography polymerase chain protocol quantitative assessment respiratory diseases Result Safe SARS-CoV-2 severity significantly subpleural the epidemic transcriptase Ultrasound was performed WHO with COVID-19 women zone [DOI] 10.1016/j.ultrasmedbio.2022.04.023 [Article Type] Conference abstract
Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, [키워드] biallelic children Clinical research Cohort develop developmental effective Efficacy and safety enrolled expected Final highlighting Infant investigator multicenter muscular Mutation Neuromuscular Newborn phase presymptomatic Respiratory Support risk Serious Adverse Event single-arm study SMN1 SMN2 survived treated Treatment Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01866-4 [Article Type] Research