Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Randomized, Controlled Trial신생아 MVA85A 백신 접종 및 인간 면역결핍 바이러스에 감염된 산모의 유아를 위한 선택적 지연 Bacille Calmette-Guerin의 안전성 및 면역원성: 2상 무작위, 대조 시험Articles and Commentaries Published on 2018-02-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] acquisition Ag85A age appear ARMS bacille Calmette-Guérin BCG BCG vaccination boost candidate CD4 CD4+ T cell CD4+ T cells CD4+ T-cell clinical control arm Controlled Delayed disease double-blind ENhance enrolled excluded Follow-up followed by functional HIV HIV infection HIV-exposed infants HIV-uninfected Human Human immunodeficiency virus IFNγ immune response immunodeficiency virus immunogenicity Infant interfere interferon gamma life magnitude memory MVA85A New Newborn no significant difference Phase 2 phenotype potential risk profiles PROTECT randomized, controlled trial reactogenicity event Registration response Result Safe Safety selective Serious Adverse Events significantly higher subsequent T cells T-cell Response tested Tuberculosis tuberculosis disease tuberculosis vaccine vaccination Vaccination strategy vaccinees [DOI] 10.1093/cid/cix834 PMC 바로가기 [Article Type] Articles and Commentaries
Characterizing the rapid spread of porcine epidemic diarrhea virus (PEDV) through an animal food manufacturing facilityResearch Article Published on 2017-11-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] analyzed baseline characterized Complete Contamination cross-contamination decrease discharged epidemic diarrhea equipment Flushing highlight indicated magnitude National New observé PEDV polymerase chain positive qPCR Quantitative reduce Regulatory retained RNA Sequencing Spread subsequent surface Swab viral pathogen Viral RNA virulent virus was used widespread [DOI] 10.1371/journal.pone.0187309 PMC 바로가기 [Article Type] Research Article
A New Bat-HKU2–like Coronavirus in Swine, China, 2017Research Letter Published on 2017-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] bat-HKU2 China conserved Coronaviridae coronavirus diarrhea domains identity New PEAV porcine enteric alphacoronavirus reported strain swine viruses zoonoses [DOI] 10.3201/eid2309.170915 PMC 바로가기 [Article Type] Research Letter
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibodyResearch Article Published on 2017-08-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied acute respiratory disease antibody Asymptomatic case asymptomatic infection Betacoronavirus Clinical signs complement confirmed case Contact tracing deaths develop dose-dependent elicited enhanced Human implication increase in individual Infection Inflammation Inflammatory response inoculated intranasal Lung disease Lung inflammation lung lobe MERS-CoV Middle East Mild naïve Neutralizing activity neutralizing antibody Neutralizing antibody response Neutralizing antibody titer New non-neutralizing antibody occur perivascular inflammation Primary infection PROTECT Protein Proteins Pulmonary infection pulmonary inflammation recruitment Reinfection reported respiratory syndrome coronavirus risk serum subsequent transfer Viral antigen viral challenge Viral protein Viral RNA waned while zoonotic [DOI] 10.1371/journal.ppat.1006565 PMC 바로가기 [Article Type] Research Article
New real time and conventional RT-PCRs for updated molecular diagnosis of infectious bronchitis virus infection (IBV) in chickens in Egypt associated with frequent co-infections with avian influenza and Newcastle Disease virusesArticle Published on 2017-03-212022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, 조류인플루엔자, [키워드] amplifying bronchitis circulating clinical sample clinical samples Co-infection Conventional coronavirus detrimental effect development diagnostic disease Genotype IBV Infection Infectious Bronchitis Virus Influenza molecular Molecular diagnosis New Nucleocapsid gene nucleotide real time real-time RT-PCR Region RT-PCR segregation strain variant virus [DOI] 10.1016/j.jviromet.2017.02.018 PMC 바로가기 [Article Type] Article
Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease SituationResearch Article Published on 2017-01-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence caused characterized Deletion deletions eight epidemic diarrhea Genetic genomic Genotype Infection Intact Isolation Japan Molecular epidemiology New nine novel ORF3 outbreak Outbreaks Pathogenesis PEDV pig Protein resulting S gene Seven situation strain the disease the Spike variant virus [DOI] 10.1371/journal.pone.0170126 PMC 바로가기 [Article Type] Research Article
New Chimeric Porcine Coronavirus in Swine Feces, Germany, 2012Letters to the Editor Published on 2016-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] chimeric virus coronavirus feces Germany New PEDV PIGS porcine coronavirus Porcine epidemic diarrhea virus Recombination TGEV transmissible gastroenteritis virus viruses [DOI] 10.3201/eid2207.160179 PMC 바로가기 [Article Type] Letters to the Editor
New emergence pattern with variant porcine epidemic diarrhea viruses, South Korea, 2012–2015Article Published on 2016-06-212022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] all age group Analysis analyzed Bayesian breakpoint China circulating classical coding gene demonstrated diffusion epidemic diarrhea explosive outbreak introduced Isolation neutralized New Novel strains outbreak pandemic PEDV Piglets Porcine epidemic diarrhea virus Protein Recombination South Korea strain suggested the antibody the Spike the United State Transmission USA Vaccine variant virus viruses while [DOI] 10.1016/j.virusres.2016.06.013 PMC 바로가기 [Article Type] Article
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative CrossResearch Article Published on 2015-10-092022-10-28 Journal: PLoS Genetics [Category] Coronavirus, [키워드] Animal host animal model approach assist candidate gene chromosome classical complex contribute contributing to disease disease severity E3 ubiquitin ligase evaluate fiber Genes Genetic genetic data Genetic variation genetics genome region Health highly pathogenic Host host gene identification identify Inflammation Inflammatory response knockout mice loci locus Lung pathology mice microbial mouse model New Noncoding RNAs outcome outcomes pathogen Pathogenesis Pathogens pathology phenotype phenotypic platform populations regulate resource respiratory viruses responses SARS patient SARS-CoV SARS-CoV infection single gene Spread statistical susceptibility loci the disease traits transcriptomic data utility Vascular viral titer virus replication viruses weight loss were used [DOI] 10.1371/journal.pgen.1005504 PMC 바로가기 [Article Type] Research Article
New Metrics for Evaluating Viral Respiratory PathogenesisResearch Article Published on 2015-06-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, 신종인플루엔자, [키워드] change changes in clinically connection evaluate Evaluating highlight human disease Infection marker Measures methodology Metrics mice New Pathogenesis Pulmonary function respiratory Respiratory function respiratory viral infections respiratory virus responses SARS-CoV severe systemic disease utility viral pathogenesis virus was used [DOI] 10.1371/journal.pone.0131451 PMC 바로가기 [Article Type] Research Article