Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy이탈리아 가정의 고양이와 개에서 SARS-CoV-2에 노출되었다는 증거Article Published on 2020-12-042022-09-12 Journal: Nature Communications [Category] MERS, 진단, 치료기술, [키워드] animals Antibody titers cats condition COVID-19 COVID-19 negative evidence of ferret ferrets Households human infection Humoral immunity infect Infection Italy Neutralizing antibodies neutralizing antibody titers PCR positive positive question raise risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody significantly more susceptibility tested transmitted understanding urgent investigation [DOI] 10.1038/s41467-020-20097-0 PMC 바로가기 [Article Type] Article
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men안드로겐 신호는 SARS-CoV-2 수용체 수준을 조절하고 남성의 심각한 COVID-19 증상과 관련이 있습니다Article Published on 2020-12-032022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] 5-alpha reductase inhibitors ACE2 ACE2 expression ACE2 regulation Analysis androgen androgen signaling angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding Cell cell membrane Clinical data Compound COVID-19 COVID-19 patient COVID-19 risk factors COVID-19 sex bias deep learning demonstrated disease disease severity disease susceptibility Diseases drug drug re-purposing elevated embryonic embryonic stem cell enzyme Genetic variant genetic variants Health Health crisis high content screening hPSC-based disease modeling identify Infection Level lung organoid lung organoids mechanism men occur offer potential treatment option Prostate reduce reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection model screening strategy Sex stem cell susceptibility target the cell the disease virtual drug screen. virus [DOI] 10.1016/j.stem.2020.11.009 PMC 바로가기 [Article Type] Article
Non-Coding RNAs and SARS-Related CoronavirusesReview Published on 2020-12-012022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] addition antiviral immune response attribute binding site Biomarker caused cellular receptor change complementary condition coronavirus COVID COVID-19 Disease progression dissemination Effect expression expression patterns globe Health Host host cell human host cell human miRNA Immunity influence inhibiting Interaction Invasion involved knowledge long non-coding RNA mechanism microRNA miRNA miRNA-induced silencing complex miRNAs ncRNA ncRNAs non-coding RNA Pathogenesis pathogenicity regions Regulation RNA RNA interference SARS SARS-CoV-2 SARS-COV-2 infection sequence severity siRNA susceptibility target therapy Treatment understanding upregulated viral genome Viral protein viral replication Viral RNA virus virus infection [DOI] 10.3390/v12121374 PMC 바로가기 [Article Type] Review
Quantifying the shift in social contact patterns in response to non-pharmaceutical interventionsResearch Published on 2020-12-012022-10-30 Journal: Journal of Mathematics in Industry [Category] COVID-19, [키워드] age Analysis available data average Canada Community Contact COVID-19 COVID-19 epidemic COVID-19 pandemic Critical demonstrated diagnosed disease transmission Diseases Effectiveness epidemiological Escalation Evolution Heterogeneous mixing household contacts identify implementation incidence increase in Infection Intervention Intervention evaluation Mathematical modelling Measures methodology Non-pharmaceutical interventions pandemic parameters per day physical distancing measures proportion public health Public health intervention public health measure quantified reduction in SARS-CoV-2 social contact susceptibility symptomatic individual Transmission Transmission model transmission route utility Variation [DOI] 10.1186/s13362-020-00096-y PMC 바로가기 [Article Type] Research
The conundrum of human immune system “senescence”인간 면역계 "노화"의 수수께끼Review Published on 2020-12-012022-09-11 Journal: Mechanisms of ageing and development [Category] SARS, 바이오마커, [키워드] accelerate added age Ageing aging antagonistic pleiotropy appear Biomarker canonical change changes changes in Confusion COVID-19 cytomegalovirus debate detrimental Effect greater Health Human Human immune system Human immunosenescence human population human populations identifying identity immune parameter immune system immunosenescence Implications in some Inflammageing longitudinal longitudinal study Older Older adults outcome question referred to resulting SARS-CoV-2 pandemic subset survival susceptibility urgency vaccination [DOI] 10.1016/j.mad.2020.111357 PMC 바로가기 [Article Type] Review
SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease당뇨병 및 COVID-19 관련 신장 질환의 SARS-CoV-2 수용체 네트워크Article Published on 2020-12-012022-09-11 Journal: Kidney international [Category] SARS, 유전자 메커니즘, [키워드] ACE ACE inhibitors ACE2 ACE2 expression ACE2 receptor acute kidney Acute kidney injury aldosterone Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bayesian biopsy Cell cellular COVID-19 dataset diabetes Diabetic diabetic kidney diabetic nephropathy Donor endomembrane epithelial epithelial cell epithelial cells expression expression pattern expression patterns healthy hospitalized patient host cells immune activation In situ hybridization infected cells Infection inhibitor Integrative analysis investigated kidney kidney damage Kidney disease kidneys living donors mechanism medication medications molecular molecular networks morbidity morbidity and mortality overlapped Patient patients with diabete proximal proximal tubules Renin renin-angiotensin-aldosterone system Research risk stratification RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2-infected cells scRNAseq susceptibility the SARS-CoV-2 Therapeutic strategies therapeutic strategy Urine Viral viral entry with COVID-19 [DOI] 10.1016/j.kint.2020.09.015 PMC 바로가기 [Article Type] Article
COVID-19 susceptibility in pregnancy: Immune/inflammatory considerations, the role of placental ACE-2 and research considerations임신 중 COVID-19 감수성: 면역/염증 고려사항, 태반 ACE-2의 역할 및 연구 고려사항Article Published on 2020-12-012022-09-12 Journal: Reproductive biology [Category] MERS, 진단, [키워드] ACE-2 ACE2 ACE2 receptor Adaptive immune response angiotensin-converting enzyme 2 Asymptomatic individuals concerning COVID-19 COVID-19 susceptibility disease pathology disease severity Endothelial cell explain highlight immune response Immunity Inflammation molecular new virus outcomes pathogenesis of COVID-19 Perspective physiological Placenta placental Pregnancy pregnant women question receptor Research SARS CoV-2 SARS-CoV-2 Serological testing stimulate susceptibility the SARS-CoV-2 virus widespread would increase [DOI] 10.1016/j.repbio.2020.10.005 PMC 바로가기 [Article Type] Article
Rapid evidence review of harm reduction interventions and messaging for people who inject drugs during pandemic events: implications for the ongoing COVID-19 responseResearch Published on 2020-12-012022-10-31 Journal: Harm Reduction Journal [Category] COVID-19, MERS, [키워드] approach conducted COVID-19 database de-duplication develop drug Effect effective equipment Evidence for inclusion greater Guidance harm reduction Health identify implication Infection infection control initial search Intervention medications National non-peer reviewed pandemic People who inject drugs (PWID) provided Rapid reduce reduction Research Result risk searched service severe disease social distancing Spread supported susceptibility [DOI] 10.1186/s12954-020-00445-5 PMC 바로가기 [Article Type] Research
Impact of Diabetes in Patients Diagnosed With COVID-19Immunology Published on 2020-12-012022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Adaptive immune response affected affecting angiotensin converting enzyme2 (ACE2) ARDS cardiovascular disease caused characterized Complication contagious contribute coronavirus disease (COVID-19) Coronavirus infection coronavirus SARS-CoV-2 country COVID-19 death diabete diabetes Diabetes Mellitus diagnosed disease Elderly patient Factor furin higher risk hyperglycemia hypertension Impact increased risk individual infections interferon induced membrane (IFITM3) low-grade inflammation mechanism metformin morbidity Mortality obese obesity pathophysiology pathway Patient respiratory risk SARS patient SARS-CoV-2 serine 2 (TMPRSS2) susceptibility syndrome transmembrane protease Transmission Treatment type 2 diabetes virus [DOI] 10.3389/fimmu.2020.576818 PMC 바로가기 [Article Type] Immunology
The association between SNPs and hepatitis B virus related acute-on-chronic liver failureArticle Published on 2020-12-012023-06-12 Journal: Infection, genetics and evolution : journal of mol [Category] B형 간염, [키워드] Chronic Hepatitis B Hepatitis B related acute-on-chronic liver failure Prognosis Single nucleotide polymorphism susceptibility [DOI] 10.1016/j.meegid.2020.104615