Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial중등도 내지 중증 CovID19 질병을 가진 입원 환자의 치료를위한 피하 Sarilumab : 실용적이고 임베디드 무작위 임상 시험Randomized Controlled Trial Published on 2022-02-252022-09-10 Journal: PLoS ONE [Category] 임상, 진단, 치료제, [키워드] adaptive added addition adopted anti-IL-6R Anti-inflammatory drugs antibody Antiviral Arm benefit clinical criteria Clinical management contribute Controlled trial COVID-19 COVID-19 disease COVID19 Data monitoring committee death Dexamethasone diagnostic diagnostic test dose Effectiveness EHR Electronic health record Eligible patients evaluated event Health health record hospitalized COVID-19 patients hospitalized patient IL-6R Importance include information initial Inpatient Inpatients intubation majority measure mechanical ventilation moderate moderate to severe numbers of patient occurred Open-label outcome participant Patient patients hospitalized positive Pragmatic primary endpoint Primary outcome Probability randomization Randomized randomized clinical trial randomized trial Remdesivir respiratory respiratory compromise Result sarilumab SARS-CoV-2 setting severe COVID-19 severe COVID-19 disease Standard of care Subcutaneous subcutaneous injection the primary endpoint Treatment Trial was increased [DOI] 10.1371/journal.pone.0263591 PMC 바로가기 [Article Type] Randomized Controlled Trial
T Cell Response After SARS-CoV-2 Vaccination in Immunocompromised Patients with Inflammatory Bowel Disease염증성 장 질환이 있는 면역 저하 환자에서 SARS-CoV-2 백신 접종 후 T 세포 반응Article Published on 2022-02-232022-09-11 Journal: Journal of Crohn's & colitis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence age analysed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody titres blood sample Blood samples Cell cellular cellular and humoral immune response Cellular immune response cellular immunity close monitoring comparable Control controls COVID19 Cutoff detect dose of vaccination Efficacy first dose group healthy healthy control healthy controls humoral immune response IBD IFN-γ immune response immune responses Immunity Immunocompromised Immunosuppression immunosuppressive infection with SARS-CoV-2 Inflammatory bowel disease one patient Patient patients PROTECT recruited regimens response SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 vaccination second dose slight increase T cell T cell response Th cells TNF TNF-α Total university vaccination [DOI] 10.1093/ecco-jcc/jjab147 PMC 바로가기 [Article Type] Article
Simulating COVID19 transmission from observed movementArticle Published on 2022-02-232022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] assumed average children Complex networks COVID-19 COVID-19 transmission COVID19 current directional High-resolution identification Infection infections Interaction interaction pattern interactions Metrics observation Patient physical predict Prophylactic proportion Psychology and behaviour radio reported risk Simulation symptomatic individuals Threats time lag Transmission Transmission dynamics Transmission model transmission rate vaccination Vaccinations viral infection [DOI] 10.1038/s41598-022-07043-4 PMC 바로가기 [Article Type] Article
Characterising COVID-19 empirical research production in Latin America and the Caribbean: A scoping reviewResearch Article Published on 2022-02-162022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Abstract abstracts article Brazil checked Clinical management contribute contributed country COVID-19 COVID-19 pandemic COVID19 cross-sectional study duplicates effort ENhance epidemiological studies explicit identify include independent International knowledge Latin America LILACS methodology pandemic Randomized controlled trial RCTs reported Research Result screened searched selected Support Vaccine WHO’ [DOI] 10.1371/journal.pone.0263981 PMC 바로가기 [Article Type] Research Article
Bayes Lines Tool (BLT): a SQL-script for analyzing diagnostic test results with an application to SARS-CoV-2-testingArticle Published on 2022-02-162023-06-14 Journal: F1000Research [Category] MERS, SARS, [키워드] Bayes COVID19 PCR test SARS-CoV-2; SQL [DOI] 10.12688/f1000research.51061.3 PMC 바로가기
Parkinsonism in viral, paraneoplastic, and autoimmune diseasesReview Published on 2022-02-152023-07-06 Journal: Journal of the neurological sciences [Category] COVID19(2023년), [키워드] Autoimmune COVID19 Paraneoplastic Parkinsonism Viral [DOI] 10.1016/j.jns.2021.120014 [Article Type] Review
Tacrolimus Treatment for Post-COVID-19 Interstitial Lung DiseaseArticle Published on 2022-02-152023-07-07 Journal: Internal medicine (Tokyo, Japan) [Category] COVID19(2023년), [키워드] Coronavirus disease 2019 COVID19 immunosuppressive agent Interstitial lung disease Respiratory failure tacrolimus [DOI] 10.2169/internalmedicine.7971-21 PMC 바로가기
Scanning the RBD-ACE2 molecular interactions in Omicron variantOmicron 변이체에서 RBD-ACE2 분자 상호작용 스캔Article Published on 2022-02-122022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor all-atom molecular dynamics simulations Amino acid amino acid substitution binding charge concern COVID19 energetics help Human human population Interaction molecular basis molecular dynamics Molecular dynamics simulation molecular interaction mutations new SARS-CoV-2 omicron Omicron variant Protein protein complex RBD RBD-ACE2 Receptor binding domain receptor complex SARS-CoV-2 scanning severity shown spike Spike protein variant variants virus [DOI] 10.1016/j.bbrc.2022.01.006 PMC 바로가기 [Article Type] Article
Comparison of mental health outcomes in seropositive and seronegative adolescents during the COVID19 pandemicArticle Published on 2022-02-102022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] acute infection asked clinical Complication conducted COVID-19 COVID19 cross-sectional enrolled increasingly Infectious diseases Inflammatory lack less median age mental health no significant difference outcome Pain pandemic Participants participated pediatric PIMS question reported symptom response SARS-CoV-2 School seronegative seropositive Seven Study design study visit Symptom Symptoms syndrome thought viral infection [DOI] 10.1038/s41598-022-06166-y PMC 바로가기 [Article Type] Article
Exhaled breath condensate (EBC) for SARS-CoV-2 diagnosis still an open debateArticle Published on 2022-02-072023-07-07 Journal: Journal of breath research [Category] COVID19(2023년), [키워드] COVID19 EBC exhaled breath condensate nasal pharyngeal swab. NPs SARS-CoV-2 [DOI] 10.1088/1752-7163/ac4dd3