CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot StudyRandomized Controlled Trial Published on 2022-06-012022-10-04 Journal: Critical Care Medicine [Category] 임상, [키워드] 1:1 95% CI adjusted Adsorption adverse event age Antibiotics Berlin C-reactive protein clinical concentrations control group Controlled COVID-19 COVID-19 patient COVID-19 patients cytokine dose Effect Endpoint enrolled excluded Gender greater groups hazard ratio Hemodialysis ICU IMPROVE inflammatory markers interleukin-6 interquartile range IQR junction measurement median membrane Monmouth Mortality mortality rate Multiple one patient Patient pilot study primary endpoint Prospective Randomized receive reduction Registered registry rescue Resolution secondary Secondary endpoints Shock Standard of care Standard therapy study inclusion the primary endpoint treatment group university hospital variable Withdrawal [DOI] 10.1097/CCM.0000000000005493 PMC 바로가기 [Article Type] Randomized Controlled Trial
Anti-SARS-CoV-2 antibody response after 2 and 3 doses of BNT162b2 mRNA vaccine in patients with lymphoid malignancies림프성 악성종양 환자에서 BNT162b2 mRNA 백신 2회 및 3회 투여 후 항-SARS-CoV-2 항체 반응Article Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected anti-CD20 Anti-CD20 antibodies Anti-CD20 antibody anti-CD38 anti-RBD Anti-RBD IgG antibody antibody concentration Antibody concentrations Antibody Response B-cell malignancies B-cell malignancy benefit binding domain booster Cell Cohort Concentration conducted Course COVID-19 COVID-19 patient COVID-19 patients disorders dose effective evaluate haematological malignancies haematological malignancy Haematologicalmalignancies humoral Humoral response humoral responses IgG Immunocompromised increment IQR lymphoid lymphomas malignancies malignancy median monoclonal Mortality mRNA vaccination mRNA vaccine of BNT162b2 Patient patients patients treated plasma Plasma cell Prophylaxis quantification RBD SARS-CoV-2 Seroconversion seroconversion rate seroconverted serological serological response serology significantly spike the disease the vaccine therapy third dose Vaccine vaccine dose [DOI] 10.1016/j.cmi.2022.02.029 PMC 바로가기 [Article Type] Article
Humoral response to SARS-CoV-2 vaccines in people living with HIVHIV 감염자의 SARS-CoV-2 백신에 대한 체액 반응Article Published on 2022-06-012022-09-12 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adjusted Analysis anti-SARS-CoV-2 antibody anti-SARS-CoV-2-antibody antibody antibody concentration Antibody Response association CD4 CD4 cell comparative statistics Concentration concentrations COVID-19 COVID-19 vaccine COVID-19 vaccines cumulative electronic patient file Factor female Generalized Germany HIV humoral immune response Humoral response identify IQR Linear model logit magnitude males median mRNA vaccine Munich PLWH quartiles robust SARS-CoV-2 SARS-CoV-2 vaccine significantly subjects threshold vaccination variable were used with HIV [DOI] 10.1007/s15010-021-01721-7 PMC 바로가기 [Article Type] Article
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds노년층에서 COVID-19 감염 또는 BNT162b2 백신 후 체액성 면역 반응: 시간 경과에 따른 진화 및 보호 역치Article Published on 2022-06-012022-09-12 Journal: GeroScience [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Anti-RBD IgG Antibody titer BNT162b2 vaccine COVID-19 COVID-19 infection decrease Dynamics Evolution first vaccination immune response Infection injection IQR Kinetics less maintain natural infection Older Patient patients with SARS-CoV-2 Protective SARS-CoV-2 serological test serology significantly higher Support symptom onset the median the SARS-CoV-2 the vaccine three groups threshold vaccination Vaccine vaccine group [DOI] 10.1007/s11357-022-00546-y PMC 바로가기 [Article Type] Article
High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trialRandomized Controlled Trial Published on 2022-05-312022-10-04 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] adjusted hazard ratio Administered administration adverse effect age anti-infective drugs baseline benefit cancers conducted confidence interval contraindication coronavirus 2 COVID-19 criteria death delirium diagnosis of COVID-19 diarrhea died early administration eligibility eligibility criteria eligible France High dose High-dose high-dose group hospital Hospitalization ICU improves intention-to-treat population investigator involved IQR less limitation Local median age medical supervision Mortality multicenter observational studies Older older patient Open-label open-label design Organ failure outcome overall mortality oxygen Oxygen requirement paO2/fiO2 participant Patient Primary outcome Prognostic factor protective effect randomization Randomized Randomized controlled trial Randomly RCT respiratory risk factor Safety Monitoring Board SARS-CoV-2 SARS-COV-2 infection Sex SpO2 Standard dose Standard-dose steering committee survival sustained treat Treatment Trial use of antibiotics Vitamin D Vitamin D supplementation vitamin D supplements were assessed with COVID-19 women worsening [DOI] 10.1371/journal.pmed.1003999 PMC 바로가기 [Article Type] Randomized Controlled Trial
Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot studyClinical Trial Published on 2022-05-262022-10-04 Journal: Stem Cell Research & Therapy [Category] 임상, [키워드] adipose administration adverse event adverse events assigned chest imaging Clinical characteristics clinical study COVID-19 COVID-19 patient COVID-19 patients D-dimer daily dose demographic data dose Efficacy Efficiency enrolled event Evidence Exosome Exosomes Extracellular vesicles feasible females Hospital admission IL-6 incidence inhalation interquartile range IQR laboratory result Lymphocyte count male median median age median time Mesenchymal stromal cell. MSC nebulized onset of symptom Patient patients patients with COVID-19 pilot study Pneumonia Primary outcome pulmonary lesion receive safety profile Serious Adverse Events serum Seven severe COVID-19 single-arm slight increase stromal cell supported tested tissue Toxicity Treatment Trial Vesicle vesicles Wuhan, China [DOI] 10.1186/s13287-022-02900-5 PMC 바로가기 [Article Type] Clinical Trial
TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trialRandomized Controlled Trial Published on 2022-05-182022-10-05 Journal: Critical Care [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI acute respiratory distress adverse events age assigned Complication correlation COVID-19 COVID-19 patient Critically ill patient death rate develop evaluate Götaland group groups intensive care intention-to-treat analysis intubation IQR males Mechanical mechanical respiratory mechanical ventilation median multicentre no significant difference observational study Patient per-protocol analysis protocol Randomized controlled trial randomized, controlled trial Randomly reduced Region Registered Respiratory Support SARS-CoV-2-infected patient selected significantly Spearman suggested Support survival syndrome the timing time Time factors tracheotomy treatment regimen with COVID-19 [DOI] 10.1186/s13054-022-04005-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19Observational Study Published on 2022-05-132022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] acute respiratory syndrome added age Anxiety Care clinics cognitive Cohort Comorbidity conducted coronavirus coronavirus disease 19 COVID-19 criteria Critical damaged delirium Depression determine disorder domain evaluated Follow-up form functional HADS hospital hospital discharge ICU intensive care Invasive mechanical ventilation IQR mechanical ventilation mechanically ventilated patient median men mental health disorders Muscle strength Patient patients performed physical Posttraumatic Stress predisposition Prevalence psychiatric disorder Psychiatric disorders Psychological pulmonary Pulmonary function SARS-CoV-2 SARS-COV-2 infection Sedation sick subsequent survey survived survivor symptom severity syndrome therapy weakness with COVID-19 [DOI] 10.1038/s41598-022-11929-8 PMC 바로가기 [Article Type] Observational Study
Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trialResearch article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, 임상, [키워드] 1:1 95% CI analyses Analysis BCG BCG vaccination Breastfeeding Cape Capital childhood computation computing Council COVID-19 COVID-19 testing died Donor double-blind Dream Efficacy enrolled Epigenetic evaluated Evidence female finding FIVE foundation functional funding had no hazard ratio healthcare healthcare worker hospitalisation hypersensitivity hypothesised Immunocompromised Infrastructure innate immune system introduced Investment IQR median age medical doctors morbidity morbidity and mortality non-specific Nurses occurred pandemic participant phase 3 trial placebo-controlled trial pregnant Prevent PROTECT provided randomised recruited reduction Registered resource respiratory tract infection Respiratory tract infections Safety SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity South Africa statistically significant Swedish Symptoms the placebo group trained immunity Treatment Tuberculosis Vaccine were assessed [DOI] 10.1016/j.eclinm.2022.101414 [Article Type] Research article
Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes-A Single-Center Experience and a Brief Review of the LiteratureCOVID-19 환자의 낮은 혈청 비타민 D는 염증 마커 및 환자의 결과와 관련이 없습니다-단일 센터 경험 및 문헌에 대한 간략한 검토Review Published on 2022-05-102022-09-11 Journal: Nutrients [Category] MERS, 바이오마커, [키워드] Admission age association C reactive protein Comorbidities Comorbidity correlation COVID-19 CRP disease disease severity evaluate except for experience ferritin fibrinogen form forms groups highest hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patients Inflammation Inflammatory Inflammatory biomarker inflammatory biomarkers IQR Laboratory laboratory procedures leukocytes literature median Mild Mild disease moderate Patient Peripheral blood peripheral blood leukocytes Prospective Study review Serum level serum levels severe COVID-19 significantly significantly higher significantly lower stratified subject Vitamin D vitamin D level vitamin D levels vitamin D serum Vitamin D status was collected was performed were assessed [DOI] 10.3390/nu14101998 PMC 바로가기 [Article Type] Review