A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients림프구 적응 면역 레퍼토리 및 전사체의 단일 세포 아틀라스는 회복기 COVID-19 환자의 연령 관련 차이를 보여줍니다Comparative Study Published on 2021-07-122022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation adaptive Adaptive immune response Adaptive immunity age Analysis antibody Atla B cell B cell receptor B cell receptors B cells B lymphocytes BCR CD4 CD8 Cell cell receptor clearance clone convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 COVID-19 disease COVID-19 patient Critical cytotoxicity dependent on difference effector elderly patients elevated GNLY groups GzmA GZMH IgA immune Immunity implicated knowledge lymphocyte Lymphocytes marker outcome Patient patients plasma Plasma cell PRF1 receptor repertoire SARS-CoV-2 Sequencing single-cell T and B cells T and B lymphocytes T cell TCRs Transcriptome transcriptomes transition VDJ repertoire [DOI] 10.3389/fimmu.2021.701085 PMC 바로가기 [Article Type] Comparative Study
Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized MedicineCOVID-19 심각도와 관련된 면역 서명: 맞춤형 의학에 대한 SARS 점수Immunology Published on 2021-07-122022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome Adaptive immune response Admission Asymptomatic Biomarker Biomarkers category clinical evolution Clinical outcome cohort of patients COVID-19 database hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients ICU identify immune Immune profile immunologic profile Immunophenotyping in silico analysis independent intensive care unit intensive care units leads management Medicine neutrophil neutrophil activation observation Patient patients personalized medicine/personalized health care Predictive respiratory distress SARS-COV-2 infection score severe disease signature syndrome the disease therapeutic strategy transcriptomic analysis Treatment [DOI] 10.3389/fimmu.2021.701273 PMC 바로가기 [Article Type] Immunology
Pathogenesis of the inflammatory bowel disease in context of SARS-COV-2 infectionSARS-COV-2 감염의 맥락에서 염증성 장 질환의 병인Review Published on 2021-07-012022-09-12 Journal: Molecular biology reports [Category] SARS, 진단, [키워드] ACE2 receptor Activation Adaptive immune response adaptive immune responses Adaptive immunity alveolar epithelial cells binding bowel carried Colitis consequence coronavirus COVID-19 Critical Crohn’s disease entry of SARS-CoV-2 expression Extracellular Factors gastrointestinal tract Genetic predisposition Host host cell IBD immune response increase in individual induce infecting Infection infection with SARS-CoV-2 Inflammation Inflammatory bowel disease inflammatory reaction initiate Innate Innate immunity intestinal intestinal enterocyte intestinal tissue molecular new SARS-CoV-2 pathway Patient patients proinflammatory cytokines receptor Research risk SARS-CoV-2 SARS-COV-2 infection Toll-like receptors ulcerative colitis virus [DOI] 10.1007/s11033-021-06565-w PMC 바로가기 [Article Type] Review
50-gene risk profiles in peripheral blood predict COVID-19 outcomes: A retrospective, multicenter cohort study말초 혈액의 50개 유전자 위험 프로필이 COVID-19 결과를 예측합니다: 후향적, 다기관 코호트 연구Multicenter Study Published on 2021-07-012022-09-11 Journal: EBioMedicine [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] 50-gene risk profiles Action Adaptive immune response analyzed applied B cells Blood CD4 CD8 Cell cellular change Chicago Cohort cohorts college COVID-19 Cutoff dendritic cells Dendritic Cells and Neutrophils Diseases expressing Features fibrosis foundation Gene Expression heart ICU ICU admission identify idiopathic Idiopathic pulmonary fibrosis IgG immune immune responses in-hospital mortality intensive care intensive care unit Interstitial lung disease investigated IPF London Lung disease Lymphocytes mechanical ventilation Mild Monocytes Mortality multicenter cohort study Neutrophils NHLBI outcomes overlap Peripheral blood plasmablasts predict predicted Predictive producing profile profiles pulmonary pulmonary fibrosis retrospective risk RNA-sequencing scientist Scoring South supported T cells T lymphocytes transcript level transcriptomic university validation was used were used [DOI] 10.1016/j.ebiom.2021.103439 PMC 바로가기 [Article Type] Multicenter Study
Low Innate Immunity and Lagged Adaptive Immune Response in the Re-Tested Viral RNA Positivity of a COVID-19 PatientCOVID-19 환자의 재검사된 바이러스 RNA 양성에서 낮은 선천성 면역 및 지연된 적응 면역 반응Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] accompanied Adaptive immune response analyzed anti-RBD anti-RBD IgA anti-SARS-CoV-2 antibody anti-Spike IgG antibody Antigen Antigen presentation B cell CD8+ Cell Characteristics chemokine chemokines Chest computed tomography Computed tomography contributed COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines delayed anti-RBD/anti-spike IgA conversion delayed antigen presentation delayed neutralizing antibody response described disappearance discharged domain expression Gene Expression IgA IgG immune mechanism Innate interferon low expression lung lesion lung lesions Mild-to-moderate moderate moderate symptoms NAb NAbs Neutralizing antibodies neutralizing antibody observation observations Patient plasma positive RBD RBD IgA re-tested positivity recent reported response RNA SARS-CoV-2 SARS-CoV-2 RNA Seroconversion severe patients significantly Symptom Symptoms T cells T cells- the SARS-CoV-2 titer Viral Viral RNA Whole blood [DOI] 10.3389/fimmu.2021.664619 PMC 바로가기 [Article Type] Immunology
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19Review Article Published on 2021-06-302022-10-04 Journal: NPJ Regenerative Medicine [Category] 임상, 치료제, [키워드] acute respiratory distress acute respiratory syndrome Adaptive immune response alleviate ARDS caused clinical clinical study clinical trial clinics coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine production Cytokine storm death decrease develop effective Efficacy enrolled evaluate fraction hypoxia immunomodulatory IMPROVE infected patient Inflammatory cytokine lack majority Mesenchymal stem cells Mild-to-moderate mortality rate MSC MSCs multiple organ failure outcome pandemic Patient patients performed placebo-controlled reduce regenerative potential Safe SARS-CoV-2 severe COVID-19 patients severe COVID-19 symptoms severe symptoms Standard of care statistically stem cell Support survival Symptoms syndrome therapeutic therapeutic potential Treatment uncontrolled viral infection [DOI] 10.1038/s41536-021-00147-x PMC 바로가기 [Article Type] Review Article
Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble MediatorsReview Published on 2021-06-292022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] absence Adaptive immune response cause chemokine COVID-19 COVID-19 disease severity COVID-19 pandemic COVID-19 patients Cytokines described disease severity excessive inflammatory response fine-tune host antiviral response immune response immunological Immunopathogenesis indicate individual Infection Innate Innate immune cells innate immune response Innate immunity mediator naïve outcome phenotype pre-existing immunity Protective provide researcher response SARS-CoV-2 SARS-COV-2 infection soluble and cellular mediators subject tissue tropism Transmissibility unique vaccinees virus [DOI] 10.3390/ijms22137017 PMC 바로가기 [Article Type] Review
First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in subjects who have recovered from COVID-19첫 번째 접종 mRNA 백신 접종은 COVID-19에서 회복된 피험자에서 SARS-CoV-2에 대한 면역학적 기억을 재활성화하기에 충분합니다.Article Published on 2021-06-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 진단, [키워드] Adaptive immune response Adaptive immunity B cell responses BNT162b2 mRNA cellular Clinical practice Cohort contrary COVID-19 COVID-19 vaccination COVID-19 vaccine determine ENhance evaluated humoral immune response IgA IgG IgM immune response Immunity immunoglobulins Immunological memory immunology individual individuals injection mandatory mRNA vaccination neutralizing antibodies titer performed question required SARS-CoV-2 SARS-COV-2 infection second dose serological subject subjects T cells tested vaccination vaccine dose vaccine injection [DOI] 10.1172/JCI149150 PMC 바로가기 [Article Type] Article
Modeling within-Host SARS-CoV-2 Infection Dynamics and Potential Treatments호스트 내 SARS-COV-2 감염 역학 및 잠재적 치료 모델링Article Published on 2021-06-142022-09-01 Journal: Viruses [Category] MERS, 진단, 치료제, [키워드] adaptive Adaptive immune response Administered anti-SARS-CoV-2 antibodies collected convalescent plasma convalescent plasma transfusion COVID-19 COVID-19 patients develop drug Dynamics effective effector cells host cells hypothetical Immune components immune response in silico infected cell infected cells Infection inhibit Innate immunity interferon Intervention Invasion mathematical mathematical model mathematical modeling modeling onset of symptoms Plasma cell Plasma cells platform Potential Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection shown Simulation target cell target cells therapy Transcription Transfusion therapy Trigger triggers Vaccines Viral Viral load virus virus infection virus-specific antibodies [DOI] 10.3390/v13061141 PMC 바로가기 [Article Type] Article
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset초기 T 세포 및 결합 항체 반응은 COVID-19 RNA 백신 효능 발병과 관련이 있습니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Adaptive immune response adaptive immune responses Analysis binding binding antibodies binding antibody BNT162b2 BNT162b2 vaccine clinical trials Cohort Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 research demonstrated detectable doses Efficacy element first dose glass healthcare worker hour immune responses Immunity Neutralizing Neutralizing activity Neutralizing antibodies Pfizer/BioNTech Phase III clinical trials primary endpoint receiving respiratory response responses RNA RNA vaccine RNA vaccines SARS-CoV-2 Severe acute respiratory syndrome single dose Support T cell T cells the vaccine undetectable vaccination Vaccine vaccine efficacy virus was performed with COVID-19 [DOI] 10.1016/j.medj.2021.04.003 PMC 바로가기 [Article Type] Article