Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M pro ) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking StudyResearch Article Published on 2020-12-232022-10-28 Journal: Scientifica [Category] COVID-19, [키워드] acute respiratory syndrome antimalarial antiretroviral drug approach AutoDock binding free energy calculated candidate caused Chloroquine complex Compound compounds coronavirus coronavirus disease COVID-19 criteria determine docking docking score drug drugs electrophilic evaluate evaluated FDA FIVE gallate glycoprotein hesperidin highest affinity humans hydroxychloroquine sulfate in vitro in vivo indicated Infection inhibit inhibitors investigated kaempferol M pro meet molecular docking nucleophilic oral bioavailability outbreak pandemic plant Potential proliferation protease protein-ligand reactivity Region researcher SARS-CoV-2 selected spike spike glycoprotein treat Treatment was performed were used [DOI] 10.1155/2020/6307457 PMC 바로가기 [Article Type] Research Article
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study콩고민주공화국 킨샤사 공립병원 크리니크 응갈리에마(Clinique Ngaliema)에 입원한 코로나19 환자의 임상적 특성: 후향적 코호트 연구Research Article Published on 2020-12-182022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, 말라리아, [키워드] Admission age analyzed antimalarial AST Characteristics Chloroquine phosphate clinical Clinical characteristics Clinique Co-infection Comorbidities Comorbidity cough COVID-19 patient death diabete disease early stage elevated epidemiological fatigue Gender help higher risk hospital Hospitalization Hospitalized hospitalized COVID-19 patients Hydroxychloroquine hypertension identify In-hospital death indicated infected with SARS-CoV-2 laboratory data majority malaria male median age medical record Mild moderate myalgia obesity objective Older Older age outcome past medical history Patient Plasmodium prevalence of COVID-19 Regression Result retrospective cohort study Retrospective study risk factor SARS-CoV-2 viral infection Shortness of breath SpO2 Symptoms Tachycardia Treatment [DOI] 10.1371/journal.pone.0244272 PMC 바로가기 [Article Type] Research Article
Clinical Profile, Treatment and Predictors during the First COVID-19 Wave: A Population-Based Registry Analysis from Castile and Leon HospitalsArticle Published on 2020-12-142022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Acute kidney injury acute respiratory syndrome addition age AKI Analysis Antibiotics antimalarial antivirals clinical Clinical characteristics Clinical outcome COVID-19 COVID-19 pandemic COVID-19 patient death Evolution Factors First wave Gender hospital hospitalized patient hospitals incidence male mechanical ventilation median Medicine Mortality mortality rate Multiple occurred outcome predictor Probability profile Prognosis registry SARS-CoV-2 Severe acute respiratory syndrome Spain steroid syndrome systemic inflammatory response the disease therapy Tocilizumab Treatment variables Ventilation [DOI] 10.3390/ijerph17249360 PMC 바로가기 [Article Type] Article
The “sex gap” in COVID-19 trials: a scoping reviewResearch article Published on 2020-11-302022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, 임상, [키워드] analyses Analysis antimalarial Antiviral Care Case series clinical trials collected convalescent plasma Corona Corticosteroid COVID-19 COVID-19 patients disease course Diversity drugs eligible Favipiravir females finding for inclusion funding Genetic genetics higher fatality rate Human hydroxychloroquine/chloroquine IL-1 IL-6 immune system immunological immunological responses include inhibitor interleukin-6 investigated male mechanism mechanisms medRxiv Modification modulating observational study pathway performed pharmacological pharmacological treatment post-hoc post-hoc analysis Prophylactic proportion Randomized controlled trials Remdesivir reported searched Sex Sex difference Stratification stratified therapeutic therapy therapy for COVID-19 umifenovir underlie UpToDate was performed [DOI] 10.1016/j.eclinm.2020.100652 [Article Type] Research article
The antimalarial activity of indole alkaloids and hybridsarticle Published on 2020-11-302024-09-01 Journal: Archiv der Pharmazie [Category] 말라리아, [키워드] alkaloids antimalarial antiplasmodial hybrid compounds indole [Article Type] article
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV3900481상, 위약 대조, 무작위, 단일 용량 상승 연구 및 자원봉사자 감염 연구를 통해 Plasmodium 포스파티딜이노시톨 4-키나제 억제제 MMV390048의 안전성, 약동학 및 항말라리아 활성을 특성화합니다.Article Published on 2020-11-152024-08-11 Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 말라리아, [키워드] antimalarial MMV390048 pharmacokinetics Plasmodium phosphatidylinositol 4-kinase Safety [DOI] 10.1093/cid/ciaa368 PMC 바로가기
Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019Review Article Published on 2020-11-022022-10-28 Journal: Annals of Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adverse effect adverse effects analyzed anti-inflammatory agent Antigen presentation antigen processing antimalarial Antiviral Autoimmune Autoimmune diseases Cardiomyopathy Cardiotoxicity clinical trial conduction defect coronavirus coronavirus disease COVID-19 Efficacy Efficacy and safety Evidence functions HCQ Hydroxychloroquine immunomodulatory in-depth analysis inhibiting life-threatening lysosomal management manifestation mechanism mechanism of action mechanisms medical supervision MHC-II pandemic reported rheumatic disease systemic lupus erythematosus TLR use of hydroxychloroquine [DOI] 10.1080/07853890.2020.1839959 PMC 바로가기 [Article Type] Review Article
Hydroxychloroquine in Hospitalized Patients with COVID-19: Real-World Experience Assessing MortalityCOVID-19로 입원한 환자의 하이드록시클로로퀸: 사망률을 평가하는 실제 경험Article Published on 2020-11-012022-08-31 Journal: Pharmacotherapy [Category] 신약개발, 임상, [키워드] 30-Day mortality 48 hour 48 hours 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age all-cause mortality Analysis antimalarial arrhythmia Assessing Azithromycin clinical trial Cohort conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database diagnosis of COVID-19 experience Follow-up group groups HCQ Hospital admission hospitalized patients Hydroxychloroquine increase in investigated Macrolide male measure medications Mortality no difference Odds ratio off-label on admission outcome overall mortality Patient patients with COVID-19 Primary outcome real-world data receiving respiratory retrospective retrospective cohort study severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 statistically statistically significant the mean were recorded [DOI] 10.1002/phar.2467 PMC 바로가기 [Article Type] Article
In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2Article Published on 2020-10-312022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome America Anti-inflammatory anti-inflammatory effect antimalarial Antiviral antiviral activity antiviral drug Antiviral effect approach approved drug Asia Clinical treatment clinically Co-infection Concentration containment measures coronavirus coronavirus disease COVID-19 doxycycline Drug discovery effective Europe evaluate experimental model expression high-risk patient identifying in vitro in vitro activity in vitro study initiated intravenous median moderate patients Prevent pro-inflammatory cytokine Prophylaxis Replication required SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 strain Severe COVID-19 Infection Spread Therapies translate Treatment Trial Vero E6 cell virus entry Wuhan, China [DOI] 10.3390/molecules25215064 PMC 바로가기 [Article Type] Article
The worldwide clinical trial research response to the COVID-19 pandemic – the first 100 daysResearch Article Published on 2020-10-262022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] Analysis antimalarial Antiviral China clinical research agenda clinical trial conducted COVID-19 COVID-19 pandemic evaluated Evolution expected feasibility fraction Health health-care hospitalized patients Hydroxychloroquine include information interquartile range Intervention investigated IQR median MOST pandemic participant Participants Prevent Randomized recruited recruitment Research resources respond Sample size social distancing tested Threats treat Treatment Trial trials USA Vaccine while [DOI] 10.12688/f1000research.26707.2 PMC 바로가기 [Article Type] Research Article