Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiologySARS-CoV-2 분기군의 글로벌 역학 및 COVID-19 역학과의 관계Article Published on 2021-04-192022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] age Analysis analyzed asymptomatic patient asymptomatic patients children clade clades country COVID-19 COVID-19 cases D614G D614G mutation Deceased distributions Epidemiology Evidence Evolution of SARS-CoV-2 Evolutionary developmental biology expansion female Female patients followed by Gender genomic genomic variation genomic variations GISAID database group increase Infectious diseases male Metadata Mild disease Mortality novel SARS-CoV-2 virus Prevalence prevalent SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus significantly higher statistical submitted virulence with mild disease [DOI] 10.1038/s41598-021-87713-x PMC 바로가기 [Article Type] Article
Impact of Treatment Regimens on Antibody Response to the SARS-CoV-2 CoronavirusSARS-CoV-2 코로나바이러스에 대한 항체 반응에 대한 치료 요법의 영향Immunology Published on 2021-04-152022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] 95% CI absence affecting age analyzed Antibody Response Antibody test antimalarial drug asymptomatic patients Cancer cephalosporins chloroquine/hydroxychloroquine Clinical characteristics convalescent stage coronavirus disease correlated COVID-19 Critical Critically ill patient determine develop Dyspnea Evidence Factor Fever global pandemic IgG IgG antibody IgG response IgM/IgG Impact Limited Mild Moderate COVID-19 moderate disease Mortality mortality rate multivariable analysis negativity onset of symptoms Patient Predictive Prognosis progressed progression reported response risk factor SARS-CoV-2 SARS-CoV-2 antibody Seroconversion Spread Symptom the patient the SARS-CoV-2 treatment regimen univariable analysis was determined was performed Wuhan [DOI] 10.3389/fimmu.2021.580147 PMC 바로가기 [Article Type] Immunology
Hydroxychloroquine and COVID-19: can we learn from the use of rituximab in systemic lupus erythematosus?하이드록시클로로퀸과 코로나19: 전신성 홍반성 루푸스에서 리툭시맙을 사용하여 배울 수 있습니까?Commentary Published on 2021-04-152022-09-01 Journal: The Pan African Medical Journal [Category] 진단, [키워드] anti-CD20 antibody Arthritis asymptomatic patient asymptomatic patients B-cell lymphoma CD20 chimeric COVID-19 debate determine disorders dose duration of treatment effective Effectiveness Efficacy Efficacy and safety evaluate HCQ hematological Hydroxychloroquine lupus erythematosus monoclonal multicentre Neuropsychiatric open Patient profile Randomized controlled trials RCT renal rheumatoid arthritis rituximab RTX Safe SAGA shown SLE SSA Standard therapy systemic lupus erythematosus the disease Treatment understanding [DOI] 10.11604/pamj.2021.38.372.29087 PMC 바로가기 [Article Type] Commentary
Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE StudyArticle Published on 2021-04-102022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen association asymptomatic patients asymptomatic subjects clinical setting complementary COVID-19 COVID-19 diagnostic testing Emergency emergency ward Evolution exhibited FOPH health plan implementation Implementing nucleocapsid protein office PanBio Patient patients positive patient Public Rapid rapid antigen test RAT resource resources RT-PCR SARS-CoV-2 selected sensitivity significantly higher specificity Standard Q Symptom symptoms onset Testing university university hospital Viral load ward [DOI] 10.3390/microorganisms9040798 PMC 바로가기 [Article Type] Article
Population-Based COVID-19 Screening in Mexico: Assessment of Symptoms and Their Weighting in Predicting SARS-CoV-2 InfectionArticle Published on 2021-04-082022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] assessment Asymptomatic COVID-19 asymptomatic patients asymptomatic subject carried Consensus COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 symptom COVID-19-related symptom Diagnosis dysgeusia early stage evaluate evaluated Fever group had no infected with SARS-CoV-2 manifestation material Musculoskeletal neurological objective oxygen saturation participant Patient positive positive result predicted ranged reduction remained representing Result RT-PCR SARS-CoV-2 SARS-COV-2 infection screened Screening sentinel significantly higher statistically study population subject Surveillance Symptoms Viral load virus spread Weighting [DOI] 10.3390/medicina57040363 PMC 바로가기 [Article Type] Article
Early mortality in hip fracture patients admitted during first wave of the COVID-19 pandemic in Northern Italy: a multicentre studyOriginal Article Published on 2021-04-052022-10-30 Journal: Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology [Category] COVID-19, MERS, SARS, [키워드] 30-day mortality rate accounted acute respiratory syndrome Admission age Asymptomatic asymptomatic patients average Care Cephalomedullary nail Complication coronavirus coronavirus disease correlation COVID-19 COVID-19 infection COVID-19 pandemic diagnosed early treatment evaluate Evidence expected First wave follow-up period group hip Hip arthroplasty hospital hospitalised in both groups Italy Level management material medical record Mortality mortality rate multicentre Neck of the femur Osteosynthesis outcome pandemic Patient patients Pertrochanteric fractures positive swab primary endpoint proximal Proximal femur reflect Result retrospective SARS-CoV-2 secondary endpoint Society surgical survival rate symptomatic Symptoms tested the mean Treatment two group unique was recorded [DOI] 10.1186/s10195-021-00577-9 PMC 바로가기 [Article Type] Original Article
Large-scale IgM and IgG SARS-CoV-2 serological screening among healthcare workers with a low infection prevalence based on nasopharyngeal swab tests in an Italian university hospital: Perspectives for public health이탈리아 대학 병원의 비인두 면봉 검사를 기반으로 한 감염 유병률이 낮은 의료 종사자를 대상으로 한 대규모 IgM 및 IgG SARS-CoV-2 혈청 검사: 공중 보건에 대한 전망Article Published on 2021-04-012022-09-11 Journal: Environmental research [Category] MERS, SARS, 진단, 치료기술, [키워드] Accuracy association Asymptomatic asymptomatic patient asymptomatic patients chemiluminescence immunoassay close contact Cohort contact with COVID-19 COVID-19 patients Decision-making demonstrated determine Diagnosis diagnosis of COVID-19 Early detection HCW HCWs healthcare worker Healthcare workers hospital IgG and IgM IgM and IgG infection prevalence Italian large cohort Nasopharyngeal swab nasopharyngeal swab test observation period Patient positive positive COVID-19 Prevalence public health risk Risk assessment RT-PCR SARS-CoV-2 SARS-COV-2 infection screened sensitivity sera serological Serological assay Serological screening serological test Serological tests specificity Swab test Symptomatic patients Viral Viral load viral spread widespread with COVID-19 [DOI] 10.1016/j.envres.2021.110793 PMC 바로가기 [Article Type] Article
Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm항-CD28 항체(TGN1412) 유발 사이토카인 폭풍 후 면역 재구성 및 임상 회복Clinical Trial Published on 2021-04-012022-08-31 Journal: Cancer immunology, immunotherapy : CII [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] adverse event adverse events antibody asymptomatic patients autoantibody Cancer immunotherapy CD28 CD4 CD8 cells clinical recovery clinical trial cognitive Cognitive deficits Concentration consequence COVID-19 cytokine Cytokine dysregulation cytokine release Cytokine release syndrome Cytokine storm Cytokines Day declined defined dendritic cell dendritic cells Depression described diagnosed dry gangrene dysregulation elevated Follow-up Gastrointestinal healthy volunteer IgE immune immune dysregulation Immune monitoring Immune-related adverse events (irAEs) immunopathology Immunotherapy infections initial irAEs irritability memory Mild-to-moderate mucosal naïve neutropenia observation one patient over Patient problem problems pruritus Psychological raynaud s phenomenon required serum cytokine serum cytokines subset suffered Symptom systemic symptoms T-cell T-cells T-regulatory cell T-regulatory cells targets TGN1412. Treatment undetectable [DOI] 10.1007/s00262-020-02725-2 PMC 바로가기 [Article Type] Clinical Trial
Saliva is a reliable and accessible source for the detection of SARS-CoV-2타액은 SARS-CoV-2 검출을 위한 신뢰할 수 있고 접근 가능한 출처입니다.Article Published on 2021-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Asymptomatic asymptomatic patients benefit collected components Concentration Concordance concordance analysis coronavirus COVID-19 described detect diagnostic test effective facilitate feasibility genetic material healthcare Inconclusive independent investigated Laboratory Mexico City Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Non-invasive NPs performed pooling Pooling strategy positive protocol reduction reproducibility Saliva saliva sample saliva samples Saliva testing Sample SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus significantly higher total RNA virus was performed [DOI] 10.1016/j.ijid.2021.02.009 PMC 바로가기 [Article Type] Article
Epidemiological investigation and intergenerational clinical characteristics of 24 coronavirus disease patients associated with a supermarket cluster: a retrospective studyResearch Article Published on 2021-04-012022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, SARS, [키워드] Admission Asymptomatic asymptomatic patients Characteristics Chest computed tomography Clinical characteristics Clinical management clinical manifestation close contact Cluster Confirmed Contact coronavirus disease COVID-19 COVID-19 patient COVID-19 patients epidemiological Epidemiological investigation Epidemiology feature Generation Hospitalization no significant difference non-specific outbreak Outbreaks pandemic Patient Pneumonia quarantine reported responsible Result Retrospective study screened Seven severity Sex symptom onset symptomatic cases symptomatic patient two group two groups underlying disease with COVID-19 [DOI] 10.1186/s12889-021-10713-z PMC 바로가기 [Article Type] Research Article