binding domain – Page 13 – Communicable Diseases Research

Role of Extracellular Vimentin in Cancer-Cell Functionality and Its Influence on Cell Monolayer Permeability Changes Induced by SARS-CoV-2 Receptor Binding Domain

Article

Published on 2021-07-122022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infection

SARS-COV-2 감염에 대한 항바이러스제 전달을 위한 바이러스 스파이크 단백질의 RBD로 태그가 지정된 세포외 소포

Article

Published on 2021-07-102022-09-11
Journal: Journal of controlled release : official journal o [Category] SARS, 치료제,

[키워드] accumulate ACE2 ACE2 receptor antiviral agent Antiviral agents approach binding domain Cell cellular cellular entry develop domain effective encapsulate endocytosed Express Extracellular extracellular vesicle Extracellular vesicles fusion hACE2 highlight in vivo Infection Interaction lung tissue lung tissues membrane membrane protein Membrane proteins modify molecular provide pseudovirus infection RBD Receptor binding domain receptor binding domain (RBD) Receptor-binding domain recognize required Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus siRNA siRNAs specific tissue specific tissues Spike protein spread of COVID-19 suppress Tagged target cells target tissue target tissues targeting the RBD the receptor-binding domain therapeutic potential Therapeutics tissue Transgenic mouse viral spike protein
[DOI] 10.1016/j.jconrel.2021.05.049 PMC 바로가기 [Article Type] Article

Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses

SARS-COV-2 및 기타 인간 코로나 바이러스에 대한 COVID-19 환자의 면역 반응 역학

Clinical Trial

Published on 2021-07-092022-09-10
Journal: PLoS ONE [Category] SARS, 비임상, 임상, 진단, 치료법,

[키워드] 229E anti-N antibodies anti-N antibody antibody Antibody titers appearance binding domain breath candidate CCL5 chemokines coronavirus coronavirus strain COVID-19 COVID-19 patient COVID-19 patients cross-reactivity CXCL-10 demonstrated disease elevated Eotaxin FIVE HCoVs Health HKU1 human coronavirus IgG IgG and IgM IgG1 IgG2 IgG3 IgG4 Inflammatory Inflammatory cytokines IP-10 MCP-1 MERS MERS-CoV multiplex N protein NL63 Non-COVID-19 nucleocapsid OC43 Patient peaking Protein Quantitative RANTES Receptor binding domain remained S protein S-RBD SARS-CoV SARS-CoV viruses SARS-CoV-2 sensitivity serological test specificity Subtypes Symptoms undetectable Vaccine
[DOI] 10.1371/journal.pone.0254367 PMC 바로가기 [Article Type] Clinical Trial

Computational design and modeling of nanobodies toward SARS-CoV-2 receptor binding domain

SARS-CoV-2 수용체 결합 도메인에 대한 나노바디의 컴퓨터 설계 및 모델링

Article

Published on 2021-07-012022-09-12
Journal: Chemical biology & drug design [Category] SARS, 진단,

[키워드] ACE2 ACE2 binding site acute respiratory syndrome addition angiotensin-converting enzyme 2 binding binding affinity binding domain binding mechanism caused CDRs complementarity-determining region complex computational protein design Contact coronavirus coronavirus disease COVID-19 docking domain effective FIVE free energy landscape grafting Health host cell host cells include Infection information inhibit Interaction mAb mAbs mechanism MERS-CoV monoclonal antibody nanobody Neutralizing neutralizing nanobody pandemic predicted Prevent Protein Protein docking RBD reported residue SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor selected sequence Seven specific neutralizing antibody Spike protein Spread stability Structure structures therapeutic drug virus virus infection
[DOI] 10.1111/cbdd.13847 PMC 바로가기 [Article Type] Article

Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

SARS-CoV-2 수용체 결합 도메인에 결합하는 2개의 공개 항체 클론형의 서열 서명

Article

Published on 2021-06-212022-09-12
Journal: Nature Communications [Category] MERS, SARS, 변종, 진단,

BNT162b2 mRNA SARS-CoV-2 Vaccine Elicits High Avidity and Neutralizing Antibodies in Healthcare Workers

Article

Published on 2021-06-182022-10-28
Journal: Vaccines [Category] COVID-19,

Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women

임산부와 수유부에서 코로나19 mRNA 백신의 면역원성

Article

Published on 2021-06-152022-09-11
Journal: JAMA [Category] MERS, SARS, 변종, 진단,

[키워드] antibody Antibody Response Antibody titers assays B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants binding binding and neutralizing antibodies binding domain Blood BNT162b2 breast milk CD4 CD8 T-cell response CD8 T-cell responses Cellular immune response Cord blood COVID-19 COVID-19 vaccine COVID-19 vaccine trials COVID-19 vaccines cross-reactive antibody enrolled enzyme enzyme-linked immunospot evaluate evaluated excluded exploratory Exploratory analysis Fever Follow-up functional Humoral and cellular immune responses IFN-γ immune responses immunogenic immunogenicity ImmunoSpot increased risk lactating lactating women Messenger RNA Moderna morbidity morbidity and mortality mRNA mRNA vaccine mRNA-1273 Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nonpregnant outcome Pfizer-BioNTech Phase 3 Population pregnant pregnant women preserved prospective cohort study receipt reduced reported response SARS-CoV-2 B.1.1.7 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant SARS-CoV-2 variants Spike-specific T-cell responses T-cell Response T-cell responses the SARS-CoV-2 transported vaccination Vaccine vaccine dose Viral Viral variants were assessed white women
[DOI] 10.1001/jama.2021.7563 PMC 바로가기 [Article Type] Article

Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan

스파이크 단백질 W152L/E484K/G769V 돌연변이가있는 R.1 계통 계통 심각한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2)의 검출

Research Article

Published on 2021-06-072022-08-13
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Author Avian Influenza binding domain clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detection domain E484K epidemiological escape mutation examined family members genomic GISAID database had no hallmark infected with SARS-CoV-2 Influenza initiative Japan life Lineage lineages MONITOR Mutation mutations N-terminal domain natural selection Nextstrain Novel coronavirus nucleic acid Patient RBD Research respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolate SARS-CoV-2 isolates Sequencing severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD Spike proteins Spread TaqMan the spike protein the United State The United States Transmissibility United States variant variants Viral viral fitness virulence virus strain whole genome Whole genome sequencing Wuhan Wuhan, China
[DOI] 10.1371/journal.ppat.1009619 PMC 바로가기 [Article Type] Research Article

SARS_CoV2 RBD gene transcription cannot be driven by CMV promoter

SARS_CoV2 RBD 유전자 전사는 CMV 프로모터에 의해 구동될 수 없습니다

Article

Published on 2021-06-012022-09-11
Journal: Virology [Category] SARS, 유전자 메커니즘, 치료기술,

Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2

SARS-CoV-2의 Spike-RBD에 특이적인 새로운 인간 중화 mAb

Article

Published on 2021-05-262022-09-01
Journal: Scientific Reports [Category] SARS, 변종, 진단,

[키워드] ACE2 ACE2 receptor Anti-spike anti-spike MAbs antibody binding domain Biotechnology candidate Cell Cell culture cell cultures cell entry contagious Diseases Drug discovery epitope expressed function glycoprotein identify IgG1 IgG4 immune system Interaction interfere Isolation mAb mAbs monoclonal monoclonal antibodies mutations Neutralizing Neutralizing activity novel pandemic Protein purified RBD receptor recognizing SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 virus scFv Side effect spike spike glycoprotein the SARS-CoV-2 virus the Spike therapeutic therapy variant virus virus entry virus infection VOC 202012/01
[DOI] 10.1038/s41598-021-90348-7 PMC 바로가기 [Article Type] Article