Targeting the Complement Cascade in the Pathophysiology of COVID-19 DiseaseReview Published on 2021-05-192022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome cascade cause clinical trials complement Complement inhibitor Complement pathway complement pathways coronavirus coronavirus disease COVID-19 Disease progression Effect Endothelial dysfunction Evidence innate immune pathway lectin pathway mannose-associated serine protease inhibitor morbidity and mortality Mounting multi-organ dysfunction Pathways SARS-CoV-2 targeting therapeutic target [DOI] 10.3390/jcm10102188 PMC 바로가기 [Article Type] Review
The impact of the SARS-CoV-2 pandemic on financial markets: a seismologic approachOriginal Research Published on 2021-05-142022-10-28 Journal: Annals of Operations Research [Category] COVID-19, [키워드] Agent-based modeling Analysis approach cascade cascades Efficiency Financial markets France G15 G18 G41 Germany Hypothesis induce Italy long-lasting observé Omori law pandemic Participants reactivity reveal SARS covid-2 SARS-CoV-2 Spain the SARS-CoV-2 The United States United Kingdom [DOI] 10.1007/s10479-021-04115-y PMC 바로가기 [Article Type] Original Research
β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19Pharmacology Published on 2021-05-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activate activating Activation acute respiratory syndrome adhesion molecules Affect affected Anti-inflammatory anti-inflammatory property Antiviral beta-caryophyllene Bioavailability candidate candidate drug cannabinoid cascade caused chemokines Clinical studies Complication coronavirus COVID-19 Cytokines dietary disease Eicosanoids functional G-protein identifying immune modulation Immunity immunomodulator immunomodulators immunomodulatory properties Infection Inflammation Inflammatory mediators inhibit investigated Ligand modulate modulating modulation molecular mechanisms natural natural products Nuclear receptors pandemic Pathogenesis pharmacokinetic pharmacological pharmacological mechanism Physicochemical properties plants preventive measures Protective public health emergency receptor receptors response SARS-CoV-2 selective signaling pathway signaling pathways target therapeutic therapeutic effect therapeutic potential therapeutic strategy therapeutic target tissue Toxicity Treatment Trinity unique [DOI] 10.3389/fphar.2021.590201 PMC 바로가기 [Article Type] Pharmacology
Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus InfectionMicrobiology Published on 2021-05-142022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] absence acute respiratory syndrome Against arise autophagy autophagy machinery cascade Chloroquine complexes connection coronavirus coronavirus disease coronaviruses (CoVs) COVID-19 COVID-19 patient cytotoxic effects deaths disease pathogenesis facilitate host cell Hydroxychloroquine inhibitor knowledge membrane vesicle other coronaviruses pathway Potential Potential treatment question recent remained Replication RNA synthesis Safe SARS-CoV-2 SARS-COV-2 infection Spread the disease Treatment Vaccine viral pathogenesis viral replication virophagy worldwide pandemic Wuhan, China [DOI] 10.3389/fmicb.2021.675419 PMC 바로가기 [Article Type] Microbiology
A Framework-Based Approach to Assessing Mental Health Impacts of the COVID-19 Pandemic on Children and AdolescentsPsychiatry Published on 2021-05-132022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Adolescent adolescents anti-contagion policy Assessing cascade children Compound COVID-19 COVID-19 pandemic develop disorder domain ecological effort Evidence exacerbated Factor Impact Intervention mental health Neuropsychiatric pandemic pathway Perspective risk Stressor susceptible Symptom viral spread youths [DOI] 10.3389/fpsyt.2021.655481 PMC 바로가기 [Article Type] Psychiatry
Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and HypothesisSystematic Review Published on 2021-05-132022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] ACE2 addition angiotensin-converting enzyme 2 article articles association bidirectional blood glucose cascade Case report Cell characterized clinical evidence Concerned conducted correlation COVID-19 cytokine profile diabetes Diabetes Mellitus disease distribution downregulated English language event Evidence explain expression Final FIVE glycemia Health hyperglycemia hypotheses Hypothesis identify immunomodulatory imperative increase increased risk Inflammatory inflammatory disorder insulin Interaction issue key factor kidneys lack lung metabolic disorder new SARS-CoV-2 overexpression pathway patients periodontal periodontal disease periodontal tissue Periodontitis Perspective Primary outcome Randomized controlled trial RAS resulting review risk SARS-CoV-2 SARS-COV-2 infection secretion Support systematic review tongue triggering type 2 diabete Type 2 diabetes mellitus Web of Science [DOI] 10.3390/medicina57050493 PMC 바로가기 [Article Type] Systematic Review
Cascading from SARS-CoV-2 to Parkinson’s Disease through Protein-Protein InteractionsArticle Published on 2021-05-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] appear cascade Central nervous system Clinical finding Cluster CNS connection coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Effect Exosome Exosomes expected explain expressed Extensive host protein host proteins human tissues hypothese Hypothesis include Interaction joint lung Lungs mechanism molecular mechanisms organs/systems Parkinson’s disease Parkinson’s disease Patient post-translational modification post-translational modifications Protein protein-protein interaction protein–protein interactions Proteins proteome provide random reported SARS-CoV-2 significantly significantly more supported Transport Trigger triggering Viral protein Viral proteins [DOI] 10.3390/v13050897 PMC 바로가기 [Article Type] Article
A Case Series of Life-Threatening Hemorrhagic Events in Patients with COVID-19Others Published on 2021-05-082022-10-30 Journal: The Indian Journal of Surgery [Category] COVID-19, [키워드] accelerate administration adopted Anticoagulant anticoagulation Antithromobotic approach Appropriate approved autopsy study bleeding bowel Care cascade cause confirmed case Consensus COVID-19 death died dosage Evidence extension hematoma hemorrhagic event mesentery organ Organ failure Patient patients patients with COVID-19 Pelvic Prophylactic protocol pulmonary involvement receiving SARS-CoV-2 Sery Seven suffered surgical syndrome therapeutic Thromboembolic event venous was performed with COVID-19 [DOI] 10.1007/s12262-021-02879-y PMC 바로가기 [Article Type] Others
A Cascade-SEME network for COVID-19 detection in chest x-ray images흉부 엑스레이 이미지에서 COVID-19 감지를 위한 Cascade-SEME 네트워크Article Published on 2021-05-012022-09-11 Journal: Medical physics [Category] SARS, 치료기술, [키워드] Accuracy added addition approach assist AUC Bacterial bacterial pneumonia can not cascade Cascade-SEMEnet Chest chest X-ray Chest X-ray images chest X-rays classification COVID COVID-19 COVID-19 case COVID-19 cases dataset detect diagnose Diagnosis diagnosis of COVID-19 effective evaluated exchange feature form framework grad-CAM highlighting Image IMPROVE Infection Infection prevention Interpretation learning lesion lung Lung infection Lungs Mask Masks measure mechanism medical resource Medical resources medical system mitigate moment network Patient Pneumonia pressure Prevention and control promoted Radiographs Region Regional regional learning. SARS-CoV-2 virus Segmentation sensitivities sensitivity significantly Specificities specificity Spread the epidemic the SARS-CoV-2 virus training set Viral pneumonia virus with COVID-19 [DOI] 10.1002/mp.14711 PMC 바로가기 [Article Type] Article
A Data-Driven Simulation of the Exposure Notification Cascade for Digital Contact Tracing of SARS-CoV-2 in Zurich, SwitzerlandResearch Published on 2021-04-302022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] Analysis bottleneck cascade checked Contact Contact tracing country DCT defined demonstrated Digital distribution downstream Effectiveness estimate evaluated exposure finding help Importance incidence information internal consistency limit longitudinal mandatory measure notification objective pandemic parameter participant Point Population positive positive result Positive test positive test result quarantine reached receiving recommendation released Relevance Research Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 testing SARS-CoV-2 transmission SARS-CoV-2–positive setting Simulation stochastic Switzerland tracing Transmission Trigger triggered upstream was performed [DOI] 10.1001/jamanetworkopen.2021.8184 PMC 바로가기 [Article Type] Research