Drastic Reduction of Bacterial, Fungal and Viral Pathogen Titers by Cuprous Oxide Impregnated Medical TextilesArticle Published on 2021-02-012022-10-31 Journal: Journal of Functional Biomaterials [Category] COVID-19, [키워드] antiviral activity Bacterial Bacterial infections Candida caused clinical setting Clostridium difficile contaminated surfaces copper coronavirus COVID-19 pandemic cuprous cuprous oxide determine Efficacy Enterococcus fungal pathogens HCoV-229E hospital Hospital acquired infections independent Infection initial Klebsiella pneumoniae Laboratory log manifested medical textiles MRSA nosocomial occur Oxide pathogen Pathogens Patient reduce reduced respiratory viral risk textile titer titre Viable viral infections viruses [DOI] 10.3390/jfb12010009 PMC 바로가기 [Article Type] Article
Management of Muscle-Invasive Bladder Cancer During a Pandemic: Impact of Treatment Delay on Survival Outcomes for Patients Treated With Definitive Concurrent ChemoradiotherapyObservational Study Published on 2021-02-012022-10-05 Journal: Clinical genitourinary cancer [Category] 임상, [키워드] 95% CI association base benefit bladder Bladder cancer chemoradiotherapy ChemoRT MIBC clinical setting clinician concurrent coronavirus disease COVID-19 COVID-19 bladder cancer curative Definitive Delay Delays in chemoRT MIBC eligible engage hazard ratio Impact interquartile range Intervention median MIBC multivariable analysis outcomes pandemic Pandemic treatment delays MIBC. Patient risk survival transurethral resection Treatment [DOI] 10.1016/j.clgc.2020.06.005 PMC 바로가기 [Article Type] Observational Study
Potent mouse monoclonal antibodies that block SARS-CoV-2 infectionSARS-CoV-2 감염을 차단하는 강력한 마우스 단일 클론 항체Accelerated Communication Published on 2021-01-302022-09-10 Journal: The Journal of Biological Chemistry [Category] 유전자 메커니즘, 진단, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed anti-SARS-CoV-2 antibodies caused cells chimeric clinical setting convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19, Coronavirus disease 2019 Critical disease disease control ELISA ELISA, enzyme-linked immunosorbent assay ERGIC, endoplasmic reticulum–Golgi intermediate compartment global pandemic Hope IF, immunofluorescence immunoassay immunoassays immunofluorescence immunoprecipitation IP, immunoprecipitatio Molecular biology Molecular pathology monoclonal antibodies monoclonal antibody mouse monoclonal antibody neutralize Neutralizing activity neutralizing antibody outbreak potent produced Prophylaxis RBD, receptor-binding domain Region Research respiratory robust RSV, respiratory syncytial virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SDS, sodium dodecyl sulfate severe acute respiratory syndrome Coronavirus spike the antibody therapy variable regions WB, western blotting western blotting Winter [DOI] 10.1016/j.jbc.2021.100346 PMC 바로가기 [Article Type] Accelerated Communication
Complement Activation in Kidneys of Patients With COVID-19COVID-19 환자의 신장에서 보체 활성화Immunology Published on 2021-01-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] activated Activation acute kidney failure acute respiratory syndrome affected Alternative pathway analyzed Antigen arteries Arterioles Artery Autopsy basement membrane biopsies biopsy C1q C3c C4d C5b-9 Capillaries capillary Cell classical pathway cleavage clinical setting Coagulation collateral tissue collectin complement Complement activation Complement pathway complement system complement—immunological term complex controls COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients CTRL deregulated develop Disseminated intravascular coagulation dominant Endothelial cell endothelial injury Factor Frequency glomerular hemolytic uremic syndrome highest immune cell responses immune response immunohistochemistry In situ hybridization in some infection with COVID-19 Injury innate immune system intravascular coagulation investigated involved kidney Kidney failure kidneys lectin lectin pathway lectin pathway activation lung marker MASP-2 membrane Most patient Most patients nuclear occur opsonization organ pathway Patient patients with COVID-19 PCNA peritubular peritubular capillaries peritubular capillary plasma Platelet Platelets positive platelets Prevent proliferation Protein protocol renal renal arteries renal tissue respiratory SARS-CoV-2 Severe acute respiratory syndrome specimen specimens subsequent therapy Thrombus thrombus formation tissue tissue injury Transplant Treatment triggering uremic syndrome virus viruses with COVID-19 worsening [DOI] 10.3389/fimmu.2020.594849 PMC 바로가기 [Article Type] Immunology
Loop‐mediated isothermal amplification for the detection of SARS‐CoV‐2 in saliva타액에서 SARS-CoV-2 검출을 위한 루프 매개 등온 증폭Research Article Published on 2021-01-262022-09-10 Journal: Microbial Biotechnology [Category] 진단, 치료기술, [키워드] addition alternative Analysis assays clinical samples clinical setting collected COVID‐19 diagnosed inhibitor inhibitory effect isothermal amplification limit of detection nasopharyngeal swabs Pandemics point of care prevented primer protease protocol reaction reverse transcription ribonuclease RNA RNA extraction RT‐PCR Saliva SARS‐CoV‐2 selected sensitivity Swab tested Treatment Viral Viral RNA [DOI] 10.1111/1751-7915.13737 PMC 바로가기 [Article Type] Research Article
Advanced echocardiographic phenotyping of critically ill patients with coronavirus-19 sepsis: a prospective cohort studyResearch Published on 2021-01-202022-10-30 Journal: Journal of Intensive Care [Category] COVID-19, [키워드] Afterload alteration Biomarker cardiac cardiac dysfunction changes characterized clinical impact clinical implications clinical setting Cluster Concentration condition correlated COVID-19 COVID-19 patient COVID-19 sepsis Critically ill Critically ill patient echocardiographic echocardiographic parameter feasibility functions hemodynamic hierarchical clustering homogeneous incidence Interaction males management median age Mortality multivariable analysis myocardial injury parameter Patient physiological positively correlated prospective cohort study recorded Result Sepsis septic patients serum supplementary material therapeutic variable were assessed were measured [DOI] 10.1186/s40560-020-00516-6 PMC 바로가기 [Article Type] Research
More skilled clinical management of COVID-19 patients modified mortality in an intermediate respiratory intensive care unit in ItalyObservational Study Published on 2021-01-152022-10-04 Journal: Respiratory Research [Category] MERS, 임상, [키워드] acute respiratory syndrome Admission assisted ventilation average Care clinical feature Clinical management clinical setting coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical care died epidemiological Follow-up hospital Hospitalized hospitalized patient ICU intensive care intensive care unit Intermediate RICU investigated Italy laboratory-confirmed lower mortality modify Mortality pandemic Patient patients who survived reported respiratory Result retrospective SARS-CoV-2 significantly suggested survival survived the patient transferred two group virus [DOI] 10.1186/s12931-021-01613-2 PMC 바로가기 [Article Type] Observational Study
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study퀘르세틴, 코로나19 유발 급성 신장 손상 치료제로서의 가능성: 네트워크 약리학 및 분자 도킹 연구 기반Research Article Published on 2021-01-142022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] 3CL ACE2 Activation active site active sites acute kidney Acute kidney injury AKI apoptosis-related signaling pathway apoptosis-related signaling pathways binding blockade Cell Chronic kidney disease CKD clinical setting contribute Critical develop effective function functions high mortality Infection Inflammatory inhibition inhibitor Injury Interaction investigated kidney Kidney disease kidneys life cycle mechanism molecular docking network pharmacology patients with SARS-CoV-2 Potential treatment protease PROTECT protective effect Protein quercetin renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease signaling pathways specific treatment target targets therapeutic therapeutic agent transition Viral viral life cycle [DOI] 10.1371/journal.pone.0245209 PMC 바로가기 [Article Type] Research Article
Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infectionAnalysis Published on 2021-01-132022-10-04 Journal: Scientific Data [Category] MERS, 비임상, 신약개발, 치료제, [키워드] addition adopted Analysis analyzed antibody biological processe biological processes Classification and taxonomy clinical setting clinically compounds coronavirus Coronavirus infection Data integration drug drug design drug target drugs effective enrichment analysis Gene ontology in vitro in vivo Infection Interaction knowledge MERS-CoV ontological Ontology platform Protein target SAR-CoV-2 SARS-CoV SARS-CoV-2 significantly Support targets viral infection viruses was used [DOI] 10.1038/s41597-021-00799-w PMC 바로가기 [Article Type] Analysis
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeuticsCOVID19 Drug Repository: 추정되는 COVID19 치료제를 찾기 위한 문헌 텍스트 마이닝AcademicSubjects/SCI00010 Published on 2021-01-082022-09-10 Journal: Nucleic Acids Research [Category] MERS, 신약개발, 임상, 치료제, [키워드] Algorithm Algorithms Analysis approved approved drugs article available data bioRxiv caused classification clinical setting clinical settings clinical trials Clustering collected Combination complexity condition COVID-19 COVID19 database description descriptions drug effective response focus information medRxiv molecular mechanism molecular mechanisms open outbreak pandemic platform PubMed Central Reasoning reported Repository Research SARS-COV-2 infection Scholar shown the WHO Treatment [DOI] 10.1093/nar/gkaa969 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010