Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD인플릭시맙은 IBD 환자에서 BNT162b2 및 ChAdOx1 nCoV-19 SARS-CoV-2 백신에 대한 면역원성 약화와 관련이 있습니다.Article Published on 2021-10-012022-09-12 Journal: Gut [Category] MERS, SARS, 진단, [키워드] 95% CI age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody concentration Antibody concentrations Antibody Response Autoimmune Autoimmune disease BNT162b2 BNT162b2 vaccine bowel ChAdOx1 ChAdOx1 nCoV-19 CLARITY Cohort Concentration concentrations COVID-19 cut-off defined Delayed disease dose Effectiveness Elecsy Evidence Fold change geometric mean IBD Immunity immunomodulator Infection Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab investigated monoclonal antibody Multivariable models of BNT162b2 outcome Patient patients patients treated Primary outcome SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose secondary Seroconversion seroconversion rate serological response single dose smoking TNF treated vaccination Vaccine Vaccines vedolizumab [DOI] 10.1136/gutjnl-2021-324789 PMC 바로가기 [Article Type] Article
Environmental and health impacts of spraying COVID-19 disinfectants with associated challengesNovel Corona Virus (COVID-19) in Environmental Engineering Perspective Published on 2021-10-012022-10-31 Journal: Environmental science and pollution research inter [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] “COVID-19 acute respiratory syndrome addition agency Anxiety approach be worn carried caused Chemicals Committee concentrations conditions coronavirus coronavirus disease country COVID-19 crown detrimental disease spread disinfectant Environmental pollution global pandemic group Health health impacts Impact international public health Microscope morphology mutagenic outbreak pandemic Panic pathogen Personal protective equipment PHEIC Pollution and COVID-19 Precaution Prevent reported robust Safe SARS-CoV-2 spike spread of COVID-19 the WHO USA Ventilation virus viruses water bodies widespread World Health Organization Wuhan, China [DOI] 10.1007/s11356-021-16575-7 PMC 바로가기 [Article Type] Novel Corona Virus (COVID-19) in Environmental Engineering Perspective
Characterization of myocardial injury in a cohort of patients with SARS-CoV-2 infectionSARS-CoV-2 감염 환자 집단에서 심근 손상의 특성화Article Published on 2021-09-242022-09-11 Journal: Medicina clínica [Category] SARS, 바이오마커, [키워드] age Arrhythmias bleeding bleeding events characterization chronic clinical outcomes Cohort cohort of patient complications concentrations consecutive patients covariates COVID-19 criteria Daño miocárdico death died Elevation English European Follow-up Future heart failure hs-TNI IMPROVE independent Infection Injury limitations male mechanical ventilation median Mild Mortalidad Mortality myocardial damage myocardial injury onset of symptom outcomes overcome Patient patients with COVID-19 patients with SARS-CoV-2 prevalent Prognosis prognostic Pronóstico Research Resultados SARS-COV-2 infection significantly significantly more Sin Spanish Stratification thrombotic time troponin troponin I Troponina [DOI] 10.1016/j.medcli.2021.02.001 PMC 바로가기 [Article Type] Article
Good Cholesterol Gone Bad? HDL and COVID-19Review Published on 2021-09-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 appear bind binding caused cholesterol class complex concentrations conditions coronavirus COVID-19 COVID-19 disease dependent on disease ENhance expression facilitate Good HDL high-density host cells increased risk Infection inverse correlation metabolism multiple study Other outbreak outcomes Particle receptor reported Respiratory disease resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle scavenger severity of COVID-19 shown Spike protein SR-B1 suppress suppressed target cells virus infection Wuhan, China [DOI] 10.3390/ijms221910182 PMC 바로가기 [Article Type] Review
Effect of COVID-19-restrictive measures on ambient particulate matter pollution in Yangon, MyanmarResearch Article Published on 2021-09-182022-10-31 Journal: Environmental health and preventive medicine [Category] COVID-19, SARS, [키워드] Air quality ambient anthropogenic carried changes in Compliance Concentration concentrations contributed coronavirus COVID-19 COVID-19 pandemic diagnosed Effect emission evaluate feasible Health highest influence Japan lowest measure Measures Miyagi Mobile PM Sensor pandemic Particulate matter pocket positive raise recent reduce reduction reduction in Research Result risk sensor social environment stay-at-home subject telework was used Yangon [DOI] 10.1186/s12199-021-01014-3 PMC 바로가기 [Article Type] Research Article
The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva인간 혈장 및 타액에서 Molnupiravir 및 대사 산물 β-d-N4-hydroxycytidine의 동시 정량을 위한 새로운 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-09-102022-09-10 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, SARS, 비임상, 치료기술, [키워드] Accuracy Acetate acetonitrile Ammonium Ammonium acetate analyte antiviral therapy caused clinical column concentrations conducted coronavirus Coronaviruses COVID-19 COVID-19 infection EIDD-2801 followed by global pandemic highly pathogenic Human plasma Infection Influenza LC-MS/MS linear m/z metabolite molnupiravir MPV N4-hydroxycytidine NHC Patient patients with COVID-19 pharmacokinetic plasma polar Precision protein precipitation quantification Saliva SRM Treatment validation was performed water [DOI] 10.1016/j.jpba.2021.114356 PMC 바로가기 [Article Type] Article
In-house reverse transcriptase polymerase chain reaction for detection of SARS-CoV-2 with increased sensitivity증가 된 감도와 SARS-COV-2의 검출을위한 사내 역전사 효소 중합 효소 연쇄 반응Article Published on 2021-09-092022-09-01 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] added advent amplification amplify amplifying applicability approach concentrations Concordance COVID-19 disease COVID-19 infection COVID-19 test demonstrated Dilution Epidemiology help management multiplex Multiplex PCR Multiplexing offer pandemic PCR condition polymerase chain positive sample primer Primers RdRP real time Real-time PCR relief resource RT-PCR SARS-CoV-2 SARS-CoV-2 genes sensitivity sets of primers shown significantly SYBR Green the SARS-CoV-2 transcriptase variable [DOI] 10.1038/s41598-021-97502-1 PMC 바로가기 [Article Type] Article
Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human RhinovirusesCommunication Published on 2021-09-072022-10-31 Journal: ChemMedChem [Category] COVID-19, SARS, [키워드] antiviral agent antiviral drug antiviral drugs approach bithiazole blocking broad-spectrum antivirals concentrations Efficacy Genetic Health high mutation rate Host Human inhibiting inhibitor mutant over phosphatidylinositol PI4KIIIb Protein Replication rhinovirus SARS-CoV-2 SARS‐CoV‐2 virus Zika Zika virus ZIKV [DOI] 10.1002/cmdc.202100483 PMC 바로가기 [Article Type] Communication
Monitoring Specific IgM and IgG Production Among Severe COVID-19 Patients Using Qualitative and Quantitative Immunodiagnostic Assays: A Retrospective Cohort Study정성적 및 정량적 면역진단 분석을 사용하여 중증 COVID-19 환자 중 특정 IgM 및 IgG 생산 모니터링: 후향적 코호트 연구Immunology Published on 2021-09-032022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료법, [키워드] Abbott acute respiratory syndrome analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody production Architect assays association Cohen’s kappa coefficient Combination Concentration concentrations confirmed COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient develop Diagnosis early phase form humoral immune response IgG IgG and IgM IgG test IgM IgM and IgG IgM antibody IgM seroconversion immunoassays immunoglobulins MONITOR monitoring Mortality Patient Pearson correlation coefficient performed positive positive relationship processed Production Qualitative Quantitative respiratory robust SARS-CoV-2 SARS-CoV-2 IgG Saudi Arabia sera seroconversion rate seroconversion rates Serological testing serum severe severe COVID-19 severity of COVID-19 Specific test results tested [DOI] 10.3389/fimmu.2021.705441 PMC 바로가기 [Article Type] Immunology
Vaping during the COVID-19 lockdown period in BelgiumResearch Article Published on 2021-09-032022-10-28 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] Belgium Concentration concentrations consequence Corona COVID-19 Electronic cigarettes example Government lockdown majority measure over participant Prevent questionnaire reached Result retrospective smoker smoking Spread supplementary material vaping virus was used [DOI] 10.1186/s12889-021-11637-4 PMC 바로가기 [Article Type] Research Article