BNT162b2 mRNA COVID-19 vaccine Reactogenicity: The key role of immunityObservational Study Published on 2021-12-172022-10-05 Journal: Vaccine [Category] SARS, 임상, [키워드] BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine Booster effect cellular immunity COVID-19 COVID-19 vaccine COVID-19 vaccines cross-reactivity elicited examined first dose HCW HCWs healthcare worker Immunity individuals Infection Level reactogenicity reduce Registered Registration reported SARS-CoV-2 second dose significantly more systemic reaction T-cell T-cell responses These data vaccination Vaccine [DOI] 10.1016/j.vaccine.2021.10.074 PMC 바로가기 [Article Type] Observational Study
Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA AssayProtocol Published on 2021-12-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy ACE2 added addition Angiotensin converting enzyme-2 binding binding domain binding inhibition assay co-occurrence competitive ELISA condition Containment measure containment measures Control correlated cross-reactivity detect detection Efficacy ELISA ELISA assay high throughput immune include initial interactions Live virus live viruses murine neutralization Neutralization assay Neutralizing non-specific parameter plaque reduction neutralization Precision Prevent protocol R 2 RBD RBD-ACE2 reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike secondary antibody sensitive sensitivity sera serum soluble ACE2 specificity Spike protein stages Treatment Vaccine development validation Virus neutralization VNT [DOI] 10.3390/vaccines9121493 PMC 바로가기 [Article Type] Protocol
Development of Serological Assays and Seroprevalence Studies of the New Coronavirus 2019 (COVID-19): Reports from Saudi ArabiaReview Published on 2021-12-142022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] applied approach country COVID-19 COVID-19 case COVID-19 patients Critical cross-reactivity described develop development Effectiveness ELISA ELISAs Epidemiology evaluated full-length healthcare healthcare worker healthy blood donor healthy blood donors highest highlight hospital IgG IgM Immunity immunoassay immunoassays lack Local lockdown micro-neutralization assay microneutralization Neutralizing activity New Non-COVID-19 patients nucleocapsid other coronaviruses peaked polymerase chain Population protocol quarantine report reported RT-PCR S1 subunit Sample size SARS-CoV-2 SARS-CoV-2 specific antibody Saudi Arabia sensitivity serology Seroprevalence specificity Spread statistical analyses study period the immunoassay Vaccine Variation [DOI] 10.3390/healthcare9121730 PMC 바로가기 [Article Type] Review
In-House Immunofluorescence Assay for Detection of SARS-CoV-2 Antigens in Cells from Nasopharyngeal Swabs as a Diagnostic Method for COVID-19Article Published on 2021-12-132022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy against SARS-CoV antibodies antibody benefit Cell clinically COVID-19 COVID-19 case COVID-19 patient cross-reactivity demonstrated detection detection of SARS-CoV-2 Diagnosis Diagnostic method domain evaluate highest identify immunofluorescence immunofluorescence assay individuals infected individuals mice Microscopy monoclonal antibody multiplex immunofluorescence Nasopharyngeal swab nasopharyngeal swabs non-infected NPs nucleocapsid protein polyclonal antibody positive prevalence of COVID-19 primary antibody Protein raised respiratory epithelial cell respiratory epithelial cells respiratory viruses SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein Sensitivity and specificity smear staining Surveillance tested the epidemic viral culture virus virus-infected cell was used were stained were used [DOI] 10.3390/diagnostics11122346 PMC 바로가기 [Article Type] Article
From Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immune Response to Cancer Onset via Molecular Mimicry and Cross-ReactivityOriginal Article Published on 2021-12-072022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory syndrome analyzed Antigen Autoimmune Cancer cancer epidemic coronavirus coronavirus 2 cross-reactive cross-reactivity database described Epitopes individual Long COVID material mimicry molecular molecular mimicry objective Onset overlap pandemic pathogen pentapeptide peptide potential mechanism Protein Proteins question respiratory response Result retrieved risk SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike gp Support Surveillance tumor-suppressor proteins tumors UniProt Viral antigen virus [DOI] 10.1055/s-0041-1735590 PMC 바로가기 [Article Type] Original Article
Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2Article Published on 2021-12-022022-10-04 Journal: Communications Biology [Category] SARS, 바이오마커, [키워드] binding CD8 competent coronavirus cross-reactive cross-reactivity Cytotoxic T cell detectable dominant epitope donors epitope exhibited functional healthy donor Hematological malignancy identification identify immunodominant epitope immunodominant epitopes Immunological memory Immunosuppressed Patient reduced SARS-CoV-2 SARS-CoV-2 spike selected selective Shimizu single-cell level stimulated T cell T cell receptors T-cell receptor TCR the SARS-CoV-2 Vaccine development viral infection [DOI] 10.1038/s42003-021-02885-6 PMC 바로가기 [Article Type] Article
CAN IgG ANTIBODIES DIRECTED AGAINST DIFFERENT TARGETS SOLVE THE PROBLEM OF FALSE-POSITIVE RESULTS IN SARS-CoV-2 SEROLOGY?다른 표적에 대한 IgG 항체가 SARS-CoV-2 혈청학에서 위양성 결과의 문제를 해결할 수 있습니까?Article Published on 2021-12-012022-09-12 Journal: Acta clinica Croatica [Category] SARS, 진단, [키워드] addition Anti- SARS-CoV-2 IgG antigens cross-reactivity ELFA ELISA False-positive results France global pandemic IgG Infection Italy medium observation offer other coronavirus Patient positive Positive predictive value positive result RT-PCR assays SARS-CoV SARS-CoV 2 SARS-CoV-2 SARS-COV-2 infection serologic test serologic tests serology serology test serology testing Spread tested [DOI] 10.20471/acc.2021.60.04.25 PMC 바로가기 [Article Type] Article
Autoimmune hepatitis after COVID-19 vaccine – more than a coincidence코로나19 백신 후 자가면역 간염 - 우연 그 이상Case Reports Published on 2021-12-012022-09-12 Journal: Journal of autoimmunity [Category] MERS, SARS, 진단, [키워드] antibody Autoimmune diseases Autoimmune hepatitis Autoimmune response COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine cross-reactivity Efficacy elevated Evolution expected first dose foci Healthcare provider Hepatitis host cells Immunoglobulin Liver histology lobular Moderna mRNA vaccine Moderna mRNA vaccine. Necrosis pandemic positive Prednisolone receiving self-tolerance suggested the vaccine Treatment vaccination Vaccine [DOI] 10.1016/j.jaut.2021.102741 PMC 바로가기 [Article Type] Case Reports
Validation of the analytical performance of nine commercial RT-qPCR kits for SARS-CoV-2 detection using certified reference material인증된 참조 물질을 사용하여 SARS-CoV-2 검출을 위한 9개의 상용 RT-qPCR 키트의 분석 성능 검증Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] analytical sensitivity approved Certified reference material clinical risk conducted Contact coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity diagnostic diagnostics false-negative false-negative results genomic RNA human coronavirus human coronaviruses IMPROVE in vitro less limit of detection limits Limits of detection N gene nine ORF pandemic PCR Probability public health emergency qPCR reaction reduce reference material respiratory viruses RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 detection selected sensitivity Sensitivity and specificity specimen Template tested two groups validation Variation variations [DOI] 10.1016/j.jviromet.2021.114285 PMC 바로가기 [Article Type] Article
Sequential Analysis of Binding and Neutralizing Antibody in COVID-19 Convalescent Patients at 14 Months After SARS-CoV-2 InfectionSARS-CoV-2 감염 14개월 후 COVID-19 회복기 환자의 결합 및 중화 항체의 순차 분석Immunology Published on 2021-11-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] Alpha Analysis anamnestic response Anti-nucleocapsid antibodies anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-spike antibodies antibodies antibody antibody kinetics Antibody Response Asymptomatic Beta binding Cohort convalescent patient Convalescent patients COVID-19 cross-reactive cross-reactivity Delta delta variant detectable example Follow-up functional functional antibody response functional antibody responses Gamma half-live humans Immunity Infection information long-lasting Longevity maintain median Month neutralization nucleocapsid offer one patient pandemic Patient persistence Post-infection prevalent strain provide re-exposure Re-infection recall reduced RNA SARS-CoV-2 significantly specificity spike Spike receptor binding domain spike variants Support symptom onset symptomatic disease tested the antibody These data variant variants of concern WA1 Wuhan [DOI] 10.3389/fimmu.2021.793953 PMC 바로가기 [Article Type] Immunology