Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses16주 간격으로 BNT162b2 mRNA 백신 접종 후 SARS-CoV-2 스파이크에 대한 강력한 체액성 면역 반응Article Published on 2022-01-122022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 진단, [키워드] ADCC Administered analyzed BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine Cohort coronavirus COVID-19 D614G delayed mRNA vaccine regimen dose doses Efficacy elicited greater health authorities humoral humoral immune response Humoral response humoral responses IMPROVE include individual infected individual infected individuals mRNA vaccine naïve individuals naïve vaccinees neutralization public health authority question raising receiving regimen response robust SARS-CoV-2 second dose significantly significantly increased spike spike glycoproteins Strong vaccine administration vaccine dose vaccine doses vaccinees variant variants variants of concern variants of interest while [DOI] 10.1016/j.chom.2021.12.004 PMC 바로가기 [Article Type] Article
Different decay of antibody response and VOC sensitivity in naïve and previously infected subjects at 15 weeks following vaccination with BNT162b2BNT162b2 백신 접종 후 15주에 경험이 없는 피험자와 이전에 감염된 피험자에서 항체 반응 및 VOC 감수성의 상이한 붕괴Research Published on 2022-01-082022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 진단, [키워드] administration All participants antibody Antibody Response applied assays BNT162b2 boost BTN162b2 vaccine Clinical characteristics comparable COVID-19 COVID-19 vaccine cross-neutralizing antibodies D614G demonstrated dose dropped Effectiveness ELISA enrolled expected highlight IgG Immunity infected with SARS-CoV-2 investigated Italy kinetic Kinetics Kruskal–Wallis test Mild naïve naïve subject naïve subjects neutralization assays neutralization titer Neutralizing activity Neutralizing antibodies neutralizing response outcomes pandemic Participants pseudovirus RBD-specific IgG recalled recipient reducing remained Result SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 VOCs second dose second wave sensitivity subject supplementary material the SARS-CoV-2 These data two group two groups vaccination Vaccine vaccine dose variants of concern VoC waning immunity [DOI] 10.1186/s12967-021-03208-3 PMC 바로가기 [Article Type] Research
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
Immunogenicity of a Heterologous Prime-Boost COVID-19 Vaccination with mRNA and Inactivated Virus Vaccines Compared with Homologous Vaccination Strategy against SARS-CoV-2 VariantsArticle Published on 2022-01-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% CI adverse event blood sample BNT162b2 collected comparable CoronaVac COVID-19 D614G declined Delta variants dose Effectiveness evaluated geometric mean titre GMT group groups heterologous vaccination heterologous vaccine homologous immunogenicity Live virus microneutralization mRNA naïve Neutralization antibody Neutralizing activity neutralizing antibody participant recruited reduced Safe SARS-CoV-2 SARS-CoV-2 variant severe adverse events Strategy the antibody response the mean the SARS-CoV-2 the vaccine Vaccination strategy Vaccine vaccine immunogenicity Vaccines variant variants virus waned wild-type [DOI] 10.3390/vaccines10010072 PMC 바로가기 [Article Type] Article
Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 20212021년 초 글로벌 COVID-19 대유행이 진행되는 동안 백신 접종률이 낮거나 높은 국가에서 SARS-CoV-2 변이체의 일배체형 분포Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Canada characterized Complete coronavirus country COVID-19 outbreak COVID-19 pandemic COVID19 D614G distribution dominant effort Epitopes evade furin furin cleavage site genome sequence Germany group Haplotype haplotypes help Impact India indicated L452R Malaysia maximum Mutation N501Y neutralization new SARS-CoV-2 Nsp12 Ongoing pandemic P323L P681H pandemic Partly vaccinated rate pathogenic profile profiles Profiling Protein proteome proteomes public health Research response to vaccination S982A SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein T19R T478K T716I Taiwan Transmissibility vaccination vaccination rate Vaccination strategies Vaccine-induced immunity variant viral mutation Viral mutations widespread [DOI] 10.1016/j.meegid.2021.105164 PMC 바로가기 [Article Type] Article
Sequence analysis for SNP detection and phylogenetic reconstruction of SARS-cov-2 isolated from Nigerian COVID-19 casesResearch article Published on 2022-01-012022-10-05 Journal: New Microbes and New Infections [Category] 변종, 유전자 메커니즘, 치료기술, [키워드] 2019-nCoV 3′UTR accounted addition Analysis average base causative pathogen characteristic characterized clade Clustering community transmission conserved Coronaviridae COVID-19 COVID-19 case Culture D614G D614G mutation disease distribution family Frequency GenBank genome sequence Genome sequence data genomic genomic region genus Betacoronavirus GISAID GISAID database highest include index case Intensive likelihood Lineage MAFFT morbidity and mortality Multiple mutants New coronavirus Nigeria Novel coronavirus ORF10 ORF1ab pandemic Phylogenetic Phylogenetic tree Phylogeny reference genome Region regions Result retrieved SARS-CoV-2 SARS-CoV-2 genome sequence severe respiratory symptom significantly higher similarity SNP SNPs spike gene Treatment Version viral sequences virus was done were used widespread [DOI] 10.1016/j.nmni.2022.100955 [Article Type] Research article
Murine monoclonal antibodies against RBD of the SARS-CoV-2 spike protein as useful analytical tools for subunit vaccine development and clinical trials소단위 백신 개발 및 임상 시험을 위한 유용한 분석 도구로서 SARS-CoV-2 스파이크 단백질의 RBD에 대한 뮤린 모노클로날 항체Article Published on 2022-01-012022-09-11 Journal: Journal of Immunological Methods [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] ACE2-RBD binding Additivity index affinities affinity Alpha Anti-RBD antibodies antibody Antigen Beta binding breath characterization clinical trial COVID-19 D614G demonstrated determine Epitopes FIVE high affinity hybridoma technology infect mAbs monoclonal monoclonal antibodies monoclonal antibody murine neutralized Neutralizing neutralizing capacity neutralizing monoclonal antibodies nine pandemic pharmacokinetic purified RBD Receptor binding domain Recognition recombinant antigens sandwich ELISA SARS-CoV-2 SARS-CoV-2 spike protein solution Spike protein stability strain subunit Subunit vaccine subunit vaccines the RBD the SARS-CoV-2 trials Vaccine development Vero cells virus was used [DOI] 10.1016/j.jim.2021.113195 PMC 바로가기 [Article Type] Article
Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia콜롬비아에서 전염병이 발생한 첫해 샘플에서 SARS-CoV-2 게놈의 돌연변이 프로필Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus base pairs Beta CDC circulating clade collected concern coronavirus correlation COVID-19 D614G diagnostic diagnostic test disease severity E484K Effectiveness Evidence followed by Gamma genetic change genetic information Genetic variation genomic genomic variant GISAID Health Organization High-throughput nucleotide sequencing host immunity interest L18F lAbel Lineage Missense MOST Mutation next generation sequencing NGS non-structural proteins nucleotide ORF1ab gene pandemic predominant recent regions S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants sequenced South America structural protein structural proteins Surveillance synonymous the SARS-CoV-2 genome the WHO Vaccines variants virus VoC WHO Whole genome sequencing World Health Organization [DOI] 10.1016/j.meegid.2021.105192 PMC 바로가기 [Article Type] Article
Neutralization of alpha, gamma, and D614G SARS-CoV-2 variants by CoronaVac vaccine-induced antibodiesCoronaVac 백신 유도 항체에 의한 알파, 감마 및 D614G SARS-CoV-2 변이체 중화Article Published on 2022-01-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] Alpha analyzed antibody collected CoronaVac CoronaVac vaccine Cytopathic effect D614G develop dose Effective strategies effective strategy efficient elicited generate genomic Genomic surveillance geometric mean geometric mean titer GMT help immune response inactivated individual Mutation neutralization neutralization potency Neutralizing Neutralizing antibodies plasma plasma samples reduction SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Surveillance vaccination Vaccine vaccine-induced antibody variant variants variants of SARS-CoV-2 Vero E6 Vero E6 cell VERO E6 cells Viral viral variant Viral variants [DOI] 10.1002/jmv.27310 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Neutralization in Convalescent Plasma and Commercial Lots of Plasma-Derived Immunoglobulin회복기 혈장 및 혈장 유래 면역글로불린 상업 로트에서의 SARS-CoV-2 중화Article Published on 2022-01-012022-09-12 Journal: BioDrugs : clinical immunotherapeutics, biopharmac [Category] MERS, SARS, 진단, [키워드] analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody average binding domain Comorbidity Concentration convalescent convalescent plasma Course COVID-19 COVID-19 pandemic D614G determine Donor effective ELISA Final heterogeneous population high variability humoral IgG immunization immunodeficiency Immunoglobulin increase in indicated intravenous investigated lot-to-lot variability maximum microneutralization neutralization neutralization capacity Neutralizing Neutralizing antibody titer neutralizing capacity normalized Patient patient population patients pharmacokinetic PID plasma produced profile Protective question RBD reactivity Research Result SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 neutralization serological Standard Support tested the WHO vaccination while [DOI] 10.1007/s40259-021-00511-9 PMC 바로가기 [Article Type] Article