Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2Article Published on 2017-01-012023-06-19 Journal: Cellular physiology and biochemistry : international journal of [Category] B형 간염, [키워드] DNA methylation hepatic stellate cell MicroRNA-9-5p TGFBR1 TGFBR2. [DOI] 10.1159/000484303
Detection of HBV cccDNA Methylation from Clinical Samples by Bisulfite Sequencing and Methylation-Specific PCRArticle Published on 2017-01-012023-06-16 Journal: Methods in molecular biology (Clifton, N.J.) [Category] B형 간염, [키워드] Bisulfite sequencing PCR DNA methylation HBV cccDNA Methylation-specific PCR. [DOI] 10.1007/978-1-4939-6700-1_7 PMC 바로가기
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood [DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article
DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver diseaseResearch Published on 2016-05-052023-06-03 Journal: Clinical Epigenetics [Category] B형 간염, Fulltext, [키워드] cirrhosis DNA methylation epigenetics hepatitis B infection Liver fibrosis [DOI] 10.1186/s13148-016-0218-1 PMC 바로가기 [Article Type] Research
Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinomaResearch Published on 2016-04-222023-06-03 Journal: Clinical Epigenetics [Category] B형 간염, Fulltext, [키워드] PAX6 DNA methylation HCV Hepatocellular carcinoma Q-MSP [DOI] 10.1186/s13148-016-0208-3 PMC 바로가기 [Article Type] Research
Serum SOX11 promoter methylation is a novel biomarker for the diagnosis of Hepatitis B virus-related hepatocellular carcinomaArticle Published on 2016-01-012023-06-19 Journal: Neoplasma [Category] B형 간염, [키워드] Biomarker DNA methylation Hepatocellular carcinoma serum SOX11 [DOI] 10.4149/311_151029N552
Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammationArticle Published on 2015-05-012023-06-25 Journal: American Journal of Respiratory Cell and Molecular [Category] 신종인플루엔자, [키워드] 5-aza-2′-deoxycytidine acute lung injury DNA methylation epigenetics FOXP3 [DOI] 10.1165/rcmb.2014-0327OC PMC 바로가기
Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem RepeatsMacrosatellites 및 Multicopy 유전자의 디지털 유전형 분석은 대규모 직렬 반복의 복사 수 변화와 관련된 새로운 생물학적 기능을 나타냅니다.Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied accumulation accumulations Analysis approach approaches association Biological Biological functions changes in copy copy number correlation Digital DNA methylation DNA methylation levels Effect Effects eukaryotic Evolution example expansion extreme FIVE focus fraction function functional Gene Expression Genes Genome genome assembly Genome-wide association study genomes genomic Genotype GWAS hallmark hallmarks human population human populations humans identify include information lead Local loci majority mechanism modulating non-human primates novel nucleotide number Organisms phenotypic diversity Population Previous studies Repeat repeated selective selective pressure sequence significantly single nucleotide single nucleotide variation SNP SNPs suppression tandem tandem repeat tandem repeats transgenic utility Variability variant variants Variation variations [DOI] 10.1371/journal.pgen.1004418 PMC 바로가기 [Article Type] Research Article
Comparative genomics of enterohemorrhagic Escherichia coli O145:H28 demonstrates a common evolutionary lineage with Escherichia coli O157:H7대장균 O145:H28의 비교 유전체학은 대장균 O157:H7과 공통 진화 계통을 보여줍니다.Research Article Published on 2014-01-102024-07-30 Journal: BMC Genomics [Category] 세균성이질, [키워드] Comparative genomics DNA methylation Enterohemorrhagic Escherichia coli O145 Shiga toxin-producing Escherichia coli [DOI] 10.1186/1471-2164-15-17 PMC 바로가기 [Article Type] Research Article
DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4 + T-Cell Population StructureDNA 메틸화는 건강한 대조군과 알레르기 환자를 분리하고 변경된 CD4 + T-세포 집단 구조를 반영할 수 있습니다.Research Article Published on 2014-01-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allergen allergic allergic rhinitis allergy alteration Altered approach assumed Author blood cell CD4 cells change changes in compared Control controls different disease DNA DNA methylation Epigenetic epigenomics etiology Evidence explain found Gene Expression gene expression profile Gene expression profiles healthy control healthy controls healthy individual healthy individuals heterogeneity highlight humans Illumina immune in vitro model individuals infectious agent infectious agents Inflammatory diseases life mechanism memory Methylation Microarrays molecular Patient PBMC PBMCs phenotype Population profile proportion proportions psoriasis purified SAR seasonal Seasonal allergic rhinitis Separate separation Stratification Structure subtype Support T cells T-cell T-cells White blood cell [DOI] 10.1371/journal.pgen.1004059 PMC 바로가기 [Article Type] Research Article