Significant changes of CD4, FOXP3, CD25, and IL6 expression level in Iranian COVID-19 patientsOriginal Article Published on 2020-01-012022-10-31 Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19, [키워드] Analysis blood sample CD25 CD4 cDNA synthesis change collected correlation COVID-19 COVID-19 patient distribution downregulated eight emerging disease evaluated Evaluating expression level expression profile FOXP3 healthy healthy control healthy controls hospitalized COVID-19 patients host immune responses IL-6 IL6 increase in indicated Inflammatory responses interleukin 6 marker patients Peripheral blood quantitative real-time PCR RNA SARS-CoV-2 severity of COVID-19 Significant significantly T cell the disease Total Treg was performed PMC 바로가기 [Article Type] Original Article
UBXN1 interacts with the S1 protein of transmissible gastroenteritis coronavirus and plays a role in viral replicationResearch Article Published on 2019-04-272022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Antiviral binding cause cDNA library Cell cells clone coronavirus Degradation diarrhea downregulated expression expression level gastroenteritis glycoprotein GST host receptor identify IFN-β in viral indicated Infection inhibition interact intestinal cell intracellular protein involved late phase morbidity and mortality negative control overexpression positive Protein protein domain protein synthesis provided regulate Replication Research responsible Sequencing sialic acid Signal transduction signaling pathways significantly significantly increased siRNA TGEV the S1 protein UBXN1 viral titer yeast [DOI] 10.1186/s13567-019-0648-9 PMC 바로가기 [Article Type] Research Article
Clara Cell 10 kDa Protein Alleviates Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis by Inhibiting Fibrinogen-Like Protein 2 ExpressionImmunology Published on 2018-12-132022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] abrogated accompanied administration allergic rhinitis ALT anti-inflammatory property Apoptosis AST Asthma CC10 Cell cells co-immunoprecipitation control group determine disease downregulated Effect examined expression Fgl2 fulminant fulminant hepatitis HBP1 Hepatitis histology Human IL-1β Immune cell in vitro Infection inhibit inhibitory effect injection innate immune responses Interaction investigated involved kDa Kupffer cells liver Liver damage Liver function Macrophage macrophages mechanism MHV-3 mice murine hepatitis virus Necrosis pathogenic peritoneal macrophage PROTECT Protein Real-time PCR Regulation Regulatory represse serum shown significantly strain suggested survival rate THP-1 TNF-α transcription factor Treatment Vein viral infection was reduced western blot [DOI] 10.3389/fimmu.2018.02935 PMC 바로가기 [Article Type] Immunology
Complexin in ivermectin resistance in body lice몸니의 이버멕틴 저항성에 있는 콤플렉스Research Article Published on 2018-08-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis animals association cDNA changes complexin correlation differentially expressed downregulated Effect evaluated Evidence expression helminthic disease helminthic diseases Human induce insecticide Interference involved Ivermectin knocking down Laboratory loci mechanism mRNA Mutation mutations neuronal nonsense mutation other infestations pediculicide premature stop codon Protein protein level Proteins proteome proteomic Proteomic analysis qRT-PCR regulated reported searched shown significantly susceptible transcript transcriptional unique upregulated Variation [DOI] 10.1371/journal.pgen.1007569 PMC 바로가기 [Article Type] Research Article
microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro *Research Published on 2018-02-072022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] Coronavirus, [키워드] Accessory activating Activation addition adopted aggravate Analysis Cell damage demonstrated diarrhea differentially expressed downregulated Effect elevated expression IL1RAP Infection interleukin-1 investigated kidney MAPK mitochondrial Mitochondrial function mitochondrial membrane potential p38 MAPK signaling pathway PK-15 positive previous study Protein proteomic Quantitative RB1 receptor reduced Regulatory retinoblastoma suppressed target targeting TGEV transmissible gastroenteritis virus upregulated Via [DOI] 10.1074/mcp.RA117.000432 PMC 바로가기 [Article Type] Research
Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila트랜스포존 조절 장애는 초파리에서 생식선 줄기 세포 분화를 제어하기 위해 dWnt4 신호를 조절합니다Research Article Published on 2016-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acts aging Cancer cancers Cell cell fate cell population cell types chromatin Control degenerative degenerative diseases differentiation differentiation defects disease downregulated Drosophila element elements encapsulation expression facilitate female Genetic Genome germline GSC independent insight lead Ligand Loss maintain mammary marker mechanism methyltransferase modulate multicellular multicellular organism mutants oogenesis organism Perspective progression promote Proteins regulate regulated repress required Signaling somatic cells STEM stem cell stem cells sustained therapeutic tissue tissues transposable elements transposon transposons upregulation virus while Wnt Wnt4 [DOI] 10.1371/journal.pgen.1005918 PMC 바로가기 [Article Type] Research Article
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB SignalingArticle Published on 2015-12-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activity Alpha Analysis Antiviral antiviral response Cell cells coronavirus Degradation dehydrogenase DNA binding downregulated enterovirus examined Exogenous expression G6PD glucose-6-phosphate dehydrogenase GTPase HCoV-229E HSCARG human coronavirus 229E IDH1 increased expression Infection inhibited IκB mechanism MX1 NADPH Necrosis NF-κB NF-κB signaling nicotinamide adenine dinucleotide overexpression phosphate promoter Protein reduced response resulting sensor siRNA suppressed susceptibility susceptible TNF- α upregulated viral gene expression viral infection virus infection [DOI] 10.3390/v7122966 PMC 바로가기 [Article Type] Article
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism Meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus ErythematosusMicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while [DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article