endothelial – Page 13 – Communicable Diseases Research

Prospective Assessment of Biomarkers of Hypercoagulability in Oncological Patients and Healthcare Workers Following Vaccination Against Sars-Cov-2 with the mRNA Vaccine. the Roadmap-COVID-19-Vaccin Study

Conference abstract

Published on 2021-11-232022-10-05
Journal: Blood [Category] 바이오마커,

Inflammation and Platelet Activation After COVID-19 Vaccines – Possible Mechanisms Behind Vaccine-Induced Immune Thrombocytopenia and Thrombosis

COVID-19 백신 후 염증 및 혈소판 활성화 - 백신 유도 면역 혈소판 감소증 및 혈전증 뒤에 가능한 메커니즘

Controlled Clinical Trial

Published on 2021-11-232022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

[키워드] Activation Adenovirus age aggregation antibodies antibody antibody production cascade Coagulation complex Complication component COVID-19 COVID-19 pandemic COVID-19 vaccine CRP E-selectin endothelial Epidemiological study event excessive inflammation Gender groups Head-to-head comparison healthy controls ICAM-1 IL-10 IL-1β IL-6 IL-8 increase in individual Inflammation Inflammatory initial Johnson & Johnson marker mRNA mRNA vaccination mRNA vaccine P-selectin pathogenesis of COVID-19 PF4 Platelet platelet activation platelet factor 4 positive promote proportion Prospective Study provided TGF-β the vaccine threshold thrombin thrombocytopenia Thromboembolic event thrombosis TNF-α TTS vaccinated individual vaccination Vaccine Vaccines Vascular VCAM-1 VITT Whole blood
[DOI] 10.3389/fimmu.2021.779453 PMC 바로가기 [Article Type] Controlled Clinical Trial

Post-Covid-19 Hemostatic Characteristics of Convalescent Patients: The Bergamo Experience

Conference abstract

Published on 2021-11-232022-10-05
Journal: Blood [Category] 바이오마커,

[키워드] Activation affected age anti-N IgG anti-S anti-S IgG anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response association Bergamo Biomarker Biomarkers candidate clinical symptom Coagulation Coagulopathy complement convalescent COVID-19 patient convalescent COVID-19 patients convalescent plasma COVID-19 COVID-19 patient D-dimer demographic characteristics different time point disease endothelial Endothelial dysfunction Endothelium Enrollment evaluate excessive inflammatory response experience explain fibrinogen Gender hemostasis activation Hemostatic Hospitalized hypercoagulable increased risk independent predictor Infection Inflammation involved large cohort Level marker mechanism median no correlation Patient patients plasma positively correlated predict predicted predictor Protein protein S recruitment reported Sample SARS-COV-2 infection severe COVID-19 severe disease severity significantly higher subsequent Symptoms tested thrombosis treated von Willebrand factor were measured
[DOI] 10.1182/blood-2021-153611 [Article Type] Conference abstract

Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

Immunology

Published on 2021-11-192022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection

Research Article

Published on 2021-11-172022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

COVID-19, Pre-Eclampsia, and Complement System

Immunology

Published on 2021-11-172022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Senolytics reduce coronavirus-related mortality in old mice

Article

Published on 2021-11-162022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, MERS,

[키워드] accumulate acute respiratory syndrome adverse outcome age amplify amplifying antibody Antibody Response Antiviral antiviral antibodies antiviral gene Apoptosis approach asked biopsies blunt caused Cell cell fate cells cellular cellular senescence changes in chronic disease Chronic diseases chronic inflammation Complete contribute coronavirus COVID-19 COVID-19 pandemic Cytokine storm Dasatinib decrease Defense drug dysfunction Effect elicited eliminated endothelial ENhance event expression Factors Gene Expression Genetic Human human cell human lung hyperinflammation Hyperinflammatory Hypothesis IFITM immune response IMPROVE in vivo increase increase in increased expression increased risk individual Infection Inflammation Inflammatory marker inflammatory protein LPS Lung epithelial cells mechanism metabolism MHV mice microbial morbidity and mortality morphology Mortality mouse hepatitis virus multi-organ failure obesity occur organ organism outcome PAMP PAMPs paracrine pathogen pathogen-associated molecular pathogen-associated molecular pattern pathogenic phenotype pro-inflammatory pro-inflammatory factors PROTECT Protein protein expression reduce reduce mortality reduced reducing regimen Resilience response resulting SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike SARS-CoV-2 spike protein SASP secrete Secretome senescence senescent senescent cell serum significantly significantly increased SPF Stress Support susceptibility targeting tissue transferred treat treated treating viral entry viral infection viral pathogen β-coronavirus
[DOI] 10.1126/science.abe4832 PMC 바로가기 [Article Type] Article

PostCOVID effect on endothelial function in hypertensive patients: A new research opportunity

Opinion

Published on 2021-11-162022-10-29
Journal: Journal of clinical hypertension (Greenwich, Conn. [Category] Coronavirus, COVID19(2023년), MERS, SARS,

Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs

Research Article

Published on 2021-11-152022-10-30
Journal: The Journal of Biological Chemistry [Category] Coronavirus, MERS, SARS,

[키워드] abicipar pegol Ala antibody block clinical development clinically DARPin DARPins, designed ankyrin repeat proteins designed ankyrin repeat protein domain domains drug Drug development drug engineering electrostatic repulsion endothelial ensovibep FIVE flexible growth HER2, human epidermal growth factor receptor 2 hGABP, human guanine-adenine-binding protein HSA, human serum albumin Ile IMPROVE improvement in silico analysis inhibitor IR, internal repeat less molecular dynamics Molecular dynamics simulation Mutation N-terminal N-terminal capping repeat Protein reduce replaced responsible SARS-CoV-2 entry temperature thermostability thermostable Thr transferred Val Vascular VEGF, Vascular endothelial growth factor was increased
[DOI] 10.1016/j.jbc.2021.101403 PMC 바로가기 [Article Type] Research Article

Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units

Clinical Trial

Published on 2021-11-082022-10-04
Journal: Critical Care [Category] MERS, 임상,

[키워드] acute respiratory distress alteration ARDS AUC baseline Brazil carried cause Concentration Control correlated COVID-19 COVID-19 patient COVID-19 patients determine dynamic endothelial endothelial damage Endothelial dysfunction Enrollment evaluated Evidence fraction group hemoglobin Hypoxemia ICU Implications in vivo intensive care unit Invasive mechanical ventilation Ischemia Local metabolic rate Microcirculation nasal near-infrared spectroscopy NIRS not differ observation organs oxygen oxygen saturation parameter peripheral positive correlation prognostic prospective observational study reactivity receiving Registered Respiratory Support Result severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity significant difference significantly Skeletal muscle Spain subject supplementary material Support syndrome Therapies Trial two groups vascular occlusion Vasopressor was performed
[DOI] 10.1186/s13054-021-03803-2 PMC 바로가기 [Article Type] Clinical Trial