Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfateResearch Article Published on 2021-06-062022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 addition binding block Cell cellular clinical parameter COVID-19 decrease epithelial cell epithelial cells explain expressed expression glycoprotein heparan sulfate host cells human lung hypoxia indicate infection rate inhibit inhibited Interaction lactoferrin lung modulating NRP1 offer pathophysiology pathway Prevent protein level RBD receptor reduce reduced reduction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Syndecan-1 the RBD the receptor-binding domain the S1 subunit the spike protein therapeutic Treatment VERO E6 cells [DOI] 10.1080/22221751.2021.1932607 PMC 바로가기 [Article Type] Research Article
Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model급속한 내피염 및 혈관 손상은 인간 폐 온칩 모델에서 SARS-CoV-2 감염을 특징짓습니다Article Published on 2021-06-042022-09-11 Journal: EMBO Reports [Category] SARS, 치료기술, [키워드] absence alveolar alveolar epithelial cell alveolar epithelial cells alveolar models CD31 cell cluster cell clusters characterized ChIP COVID-19 Cytokine storm endothelial Endothelial cell endothelial cell damage endothelial cells Endotheliitis epithelial cell epithelial cells expression IL-6 immune immune cells individual cell individual cells Infection Inflammatory response inhibition interleukin interleukin-6 lung microenvironment occur organ organ-on-chip persist Prevent Protein Rapid reduce RNA SARS-COV-2 infection secretion severe cases Tocilizumab Vascular damage Vasculitis Viral RNA virions [DOI] 10.15252/embr.202152744 PMC 바로가기 [Article Type] Article
The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent MannerArticle Published on 2021-06-032022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACE2 acute lung injury acute respiratory distress acute respiratory syndrome AKT ALI ARDS Betacoronavirus Calu-3 Cell characterized chemokine chemokines CXCL9 contribute contributing to coronavirus Coronavirus disease 2019 COVID-19 CXCL10 CXCL11 CXCL9 cytokine Cytokine storm cytokines IL-6 develop elevated enzyme epithelial cell feature Gene Expression GSK690693 hACE2 mice human lung hyperinflammation IFN-γ IL-6 immunostimulatory include increase in increases in infected with SARS-CoV-2 inflammatory state inhibitor kinase lung mechanical ventilation mice overexpression pandemic pathway positive individual pro-inflammatory pulmonary complication reduced reducing responsible RNA virus Sample SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 Signaling signaling pathway significantly small molecule inhibitor syndrome target TNFα transcript Transcription transgenic Treatment upregulation were used [DOI] 10.3390/v13061062 PMC 바로가기 [Article Type] Article
Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progressionMaackia amurensis seed lectin(MASL)이 SARS-CoV-2 감염 및 COVID-19 질병 진행을 억제할 가능성이 있는 구강 편평 세포에 다면발현 작용을 한다는 증거Article Published on 2021-06-012022-09-11 Journal: Experimental cell research [Category] SARS, 치료제, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 proteins ACE2 receptor addition agent Antiviral antiviral agent ARDS bind binding can be used caused Cell confirmed COVID-19 case COVID-19 COVID-19 disease COVID-19 patients Culture death decrease epithelial cell epithelial cells Express expression glycosylated glycosylation host cells identify infect infect cell Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inhibit inhibit SARS-CoV-2 international public health kidney lectin Maackia amurensis Modification oral oral mucosa Oral squamous cells pandemic pleiotropic progression Protein respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sialic acid Spike protein squamous suppresse target the SARS-CoV-2 the SARS-CoV-2 virus viral-host interaction [DOI] 10.1016/j.yexcr.2021.112594 PMC 바로가기 [Article Type] Article
Mechanism of Ligand Recognition by Human ACE2 Receptor인간 ACE2 수용체에 의한 리간드 인식 메커니즘Article Published on 2021-05-272022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 신약개발, 치료제, [키워드] accelerated ACE2 ACE2 receptor active site acute respiratory syndrome addressed Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding conformational conformations coronavirus coronaviruses SARS-CoV Critical diabetes Diseases drug design drug target enzyme epithelial cell epithelial cells expected experimental structure expressed facilitate flexible heart heart failure homeostasis Human human ACE2 human ACE2 receptor human diseases hypertension inhibitor kidney Ligand Lungs mechanism MLN-4760 molecular molecular dynamics pancreas pulmonary diseases receptor Recognition Regulation renal Renin renin-angiotensin system SARS-CoV-2 Severe acute respiratory syndrome X-ray [DOI] 10.1021/acs.jpclett.1c01064 PMC 바로가기 [Article Type] Article
Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cellsResearch Article Published on 2021-05-252022-10-28 Journal: Virulence [Category] Coronavirus, [키워드] aggravate Air-liquid interface air-liquid interface culture airway epithelial cell aminopeptidase N applied caused cellular cellular receptor circulating Clinical signs Co-infection Complete inhibition coronavirus Coronavirus infection Coronavirus replication Culture detectable determinant epithelial cell H3N2 Human implication Infection Influenza virus innate immune response intervals molecular mechanism porcine aminopeptidase N porcine respiratory coronavirus porcine respiratory disease complex receptor Replication Respiratory Coronavirus responsible SARS-CoV-2 Seasonal influenza SIV super-infection swine influenza virus the timing time intervals tracheal upregulation viral interference virus virus infection viruses [DOI] 10.1080/21505594.2021.1911148 PMC 바로가기 [Article Type] Research Article
Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review구강 조직 및 세포에서 SARS-CoV-2의 존재 및 진입 요인: 체계적인 검토Review Published on 2021-05-232022-09-10 Journal: Medicina [Category] SARS, 치료기술, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme carried Cell cell layer cells Consequences coronavirus COVID-19 database entry factors epithelial epithelial cell epithelial cells expressed expression Factor furan furin horny layer inclusion criteria independent infect item material Meta-analysis myoepithelial cells objective oral oral cavity oral mucosa oral tissue oral tissues Other pandemic Presence PRISMA Protein provide reported Reporting researchers respiratory review salivary gland salivary glands SARS-CoV-2 SARS-CoV-2 positive patients Serine severe acute respiratory syndrome Coronavirus Symptom systematic review TMPRSS TMPRSS11D TMPRSS2 TMPRSS3 TMPRSS4 TMPRSS5 TMPRSS7 tongue transmembrane serine protease variety virus infection Web were used [DOI] 10.3390/medicina57060523 PMC 바로가기 [Article Type] Review
GABA A -Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected MiceArticle Published on 2021-05-232022-10-28 Journal: Viruses [Category] COVID-19, [키워드] administration agonist Anti-inflammatory effects approach candidate Cell clinically coronavirus Coronavirus infections Coronavirus replication Course COVID-19 death death rate epithelial cell Express GABA GABA-receptors help immune system Infection information limit lung injuries Lungs mice mouse hepatitis virus (MHV) murine hepatitis virus Pneumonitis receptor reduced Safe severity shown significantly Symptoms therapeutic effect therapy treat Treatment viral infection Viral load [DOI] 10.3390/v13060966 PMC 바로가기 [Article Type] Article
Dysregulation of Pulmonary Responses in Severe COVID-19심각한 COVID-19에서 폐 반응의 조절 장애Communication Published on 2021-05-212022-09-01 Journal: Viruses [Category] SARS, 바이오마커, 진단, [키워드] B cells BALF Bronchoalveolar lavage fluid Cell cells contribute coronavirus disease Coronavirus disease 2019 COVID-19 dataset epithelial cell epithelial cells expressing HAS2 high mortality Hyaluronan IFN-I IFNA1 IgA IgA-expressing lower expression macrophages matrix metalloproteinase matrix metalloproteinases Mild disease PAI-1 Patient Potential biomarker potential biomarkers predict pulmonary Pulmonary pathology respiratory Respiratory failure respiratory tract infection response risk factor Risk factors severe COVID-19 severe disease single-cell susceptibility Symptom Th17 TLR7 TLR8 Toll-like receptor toll-like receptor 7 type I interferon with mild disease [DOI] 10.3390/v13060957 PMC 바로가기 [Article Type] Communication
Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19?레스베라트롤 흡입 제형이 COVID-19에 대한 잠재적인 보조 치료제로 간주될 수 있습니까?Review Published on 2021-05-192022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjunct administration airways Anti-inflammatory Antiviral antiviral activities antiviral activity antiviral drug Asymptomatic Bioavailability Can caused Cell culture Characteristics characterized Clinical practice Compound Concentration coronavirus COVID-19 COVID-19 severity cytokine Cytokine storm disease downregulate effective epithelial epithelial cell evaluated excessive inflammatory response experimental models Formulation global healthcare IMPROVE Infection Inhaled inhaled formulations inhibit SARS-CoV-2 involved leads mechanism Mild molecule monoclonal antibodies oral administration outcomes pandemic Patient pharmacokinetic Pneumonia polyphenol Potential Replication respiratory Respiratory failure respiratory tract illness resveratrol Safe SARS-CoV-2 SARS-CoV-2 replication severe viral pneumonia shown Treatment upper respiratory tract Viral Viral pneumonia viral replication [DOI] 10.3389/fimmu.2021.670955 PMC 바로가기 [Article Type] Review