The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 PatientsReview Article Published on 2020-09-242022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] acute respiratory disease acute respiratory distress acute respiratory syndrome adhere administration affected agent alveolar inflammation ARDS Bone marrow Cell cell-based therapies clinical trial coronavirus COVID-19 COVID-19 patient COVID-19 patients disease Efficacy epithelia example Exosome highlight lung injuries MSC MSCs pandemic pathological condition patients Pneumonia Potential Quality control respiratory tract risk SARS-CoV-2 shown significantly lower STEM stem cell stem cells Support syndrome therapeutic therapeutic potential therapy treating COVID-19 World Health Organization [DOI] 10.1155/2020/8835986 PMC 바로가기 [Article Type] Review Article
Rationale for the Use of Radiation-Activated Mesenchymal Stromal/Stem Cells in Acute Respiratory Distress Syndrome급성 호흡곤란 증후군에서 방사선 활성화 중간엽 간질/줄기세포 사용의 근거Review Published on 2020-09-022022-09-11 Journal: Cells [Category] SARS, 비임상, [키워드] activated acute respiratory-distress syndrome alleviate Analysis Annexin annexin A1 ARDS breath caused Cell Cell therapy cells characteristic Combination conditions COVID-19 dramatic increase Exosome Exosomes experimental radiotherapy greater Hypothesis hypothetical hypoxia IMPROVE Inflammation intensive care intensive care unit life-threatening load mesenchymal cells Mesenchymal stem cells Metastasis mice microvesicle Microvesicles MSC MSCs Patient Pneumonia Protein Proteins proteomic Proteomic analysis Radiation radiobiology Radiotherapy rationale reduce released respiratory respiratory capacity SARS-CoV-2 secreted shown significant difference significantly stimulated Symptom the cells therapeutic strategy therapy transplantation Tumor [DOI] 10.3390/cells9092015 PMC 바로가기 [Article Type] Review
Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatmenArticle Published on 2020-08-312023-06-15 Journal: BMB reports [Category] MERS, [키워드] COVID-19 Exosome immunomodulation Mesenchymal stem cells (MSCs) Ongoing Clinical trials therapy [DOI] 10.5483/BMBRep.2020.53.8.121 PMC 바로가기
Nano-Vesicle (Mis)Communication in Senescence-Related PathologiesReview Published on 2020-08-262022-10-31 Journal: Cells [Category] Coronavirus, MERS, [키워드] aging apoptotic bodies biological fluid cells cellular senescence changes COVID-19 COVID-19 infections Critical death Diseases Exosome exosome biogenesis Exosomes extracellular vesicle Extracellular vesicles heterogeneous group homeostasis information involved Microvesicles miRNA multivesicular body nucleic acids organ physiological plasma Potential biomarker Probability Protein Saliva senescent Signaling Structure susceptibility Transport Urine Vesicle [DOI] 10.3390/cells9091974 PMC 바로가기 [Article Type] Review
Extracellular Vesicle-Related Thrombosis in Viral InfectionReview Published on 2020-08-262024-09-02 Journal: International Journal of General Medicine [Category] 대상포진, [키워드] Exosome extracellular vesicle microvesicle thrombosis viral infection [DOI] 10.2147/IJGM.S265865 PMC 바로가기 [Article Type] Review
Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients?Review Published on 2020-08-262022-10-06 Journal: Journal of Clinical Medicine [Category] 진단, [키워드] acute lung injury acute myocardial injury acute respiratory distress acute respiratory syndrome angiotensin-converting enzyme 2 animal model Anti-inflammation Anti-inflammatory antiviral therapy ARDS arrhythmia cardiovascular system caused clinical evidence Complication coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient develop disease Exosome heart failure Hypothesis Ill immunomodulation immunomodulatory implication Infection intensive care units lung Lungs management mechanical ventilation mesenchymal stem cell-derived exosomes MSCs myocardial injury option pandemic pathogenesis of SARS-CoV-2 patients with SARS-CoV-2 SARS-CoV-2 STEM stem cell Support syndrome the disease therapeutic options utility viral disease Wuhan, China [DOI] 10.3390/jcm9092762 PMC 바로가기 [Article Type] Review
Potential therapeutic application of mesenchymal stem cell-derived exosomes in SARS-CoV-2 pneumoniaReview Published on 2020-08-142022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, [키워드] acute respiratory distress acute respiratory syndrome affecting anti-inflammatory effect ARDS article Biomarker carried Cell characteristic Combination coronavirus country cytokines trigger edema effective antiviral treatment Efficacy Exosome Exosomes function Health induce Inflammation Inflammatory cytokines lung management Mesenchymal stem cells new virus outbreak Potential pulmonary fibrosis Result SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2 virus infection searched secretion selected stem cells syndrome the patient therapeutic tissue regeneration Treatment Vaccine virus pneumonia [DOI] 10.1186/s13287-020-01866-6 PMC 바로가기 [Article Type] Review
Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) casesReview Published on 2020-06-222022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Affect anti-inflammatory macrophages ARDS B cells clinical study clinical trial coronavirus coronavirus disease country COVID-19 Cytokine storm dendritic cells Effect Exosome Exosomes health condition healthcare Immune cell induce initiated mechanism mesenchymal stem cell Mesenchymal stem cells MSC MSCs multiple organ failure Novel coronavirus novel coronavirus disease Registered Regulatory resolved SARS-CoV-2 SARS-COV-2 infection Severe case Spread stem cell syndrome T cells therapy Treatment Trial trials virus worldwide pandemic [DOI] 10.1186/s41232-020-00121-y PMC 바로가기 [Article Type] Review
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infectionArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Activation adaptive affecting Autoimmune Autoimmunity being binding Cell cell membrane Characteristics clinical setting clinical study component COVID-19 Critical Cytokine storm Cytokines cytosolic disorder effective EVs exceptional Exosome Exosomes Extensive Extracellular extracellular vesicle Extracellular vesicles Factor function Growth factors immune immune cells Immunological disorders immunomodulator Inflammation inflammatory disease Inflammatory response inhibiting Intercellular communication investigated lower risk Lung pathology membrane mesenchymal stem cell Mesenchymal stem cells Microvesicles Migration miRNA Mortality mRNA MSC MSCs outcome pandemic paracrine parent cells pathway proliferation regenerative regulate rejection Research SARS-CoV-2 SARS-COV-2 infection secreted secretion target cell tested therapeutic agent Therapies therapy tolerogenic immune response transcription factors Treatment triggered unique variety [DOI] 10.3906/biy-2002-79 PMC 바로가기 [Article Type] Article
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19Clinical Trial Published on 2020-06-152022-10-06 Journal: Stem cells and development [Category] SARS, 진단, [키워드] absolute neutrophil count acute phase reactant acute respiratory distress administration adverse event Allogeneic ARDS average bone Bone marrow C-reactive protein CD3 CD4 CD8 clinical status cohort study COVID-19 criteria Critically ill Cytokine storm D-dimer declined determine downregulate Efficacy evaluated Exosome expired ferritin fraction Future Immunity improvement intravenous dose Lymphocyte count lymphopenia Marrow MSC nonrandomized Open-label oxygen Oxygenation p value PaO Patient polymerase chain provided Randomized controlled trial RCTs reduction remained safety endpoint safety profile SARS-CoV-2 severe COVID-19 single hospital STEM stem cell survival rate syndrome therapeutic therapeutic potential Treatment [DOI] 10.1089/scd.2020.0080 PMC 바로가기 [Article Type] Clinical Trial