Do COVID-19 and SARS Gene Complexities and Variations Help Overcome the Knowledge Gap?Infectious Disease Published on 2020-06-042022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome caused complexity Control coronavirus Coronaviruses COVID-19 develop disease Diseases effective Epidemics explain HCoV-229E HCoV-OC43 help Human human coronavirus human coronavirus 229E human coronavirus OC43 human gene illness illnesses immune response immune system individual Infection intestinal not affected pathogen pathogenic pre-existing immunity reflected replicate Research respiratory tract respond risk RNA virus SARS SARS-CoV-2 similarities Spread Symptom Symptoms the disease Transmission Vaccine Variation virus [DOI] 10.7759/cureus.8439 PMC 바로가기 [Article Type] Infectious Disease
Development of a reverse transcription-loop-mediated isothermal amplification as a rapid early-detection method for novel SARS-CoV-2Article Published on 2020-05-182022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] addition can be used collected colorimetric detection contribute Coronaviruses COVID-19 COVID-19 patient cross-reactivity detect Detection limit development Diagnostic method diagnostics disease disease-causing evaluated exhibited H3N2 H5N1 H7N9 HCoV-229E HCoV-NL63 HCoV-OC43 HRV Influenza virus isothermal amplification Laboratory less MERS-CoV Molecular diagnosis MPV Novel coronavirus Nucleocapsid gene outbreak primer set Public health response qRT-PCR researcher reverse transcription reverse transcription-loop-mediated isothermal amplification RNA copy RT-LAMP SARS-CoV SARS-CoV-2 Sensitivity and specificity specimen Spread suspected patients the SARS-CoV-2 Transmission Viral RNA virus [DOI] 10.1080/22221751.2020.1756698 PMC 바로가기 [Article Type] Article
Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs against Human Coronavirus 229E (HCoV-229E)Brief Report Published on 2020-05-172022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] 229E activity Antiviral antiviral activity can be used cells clinical trial Comparative Compound compounds concentrations conjugate Conjugates COVID-19 cytotoxicity determine DNA polymerase EFdA exhibited fibroblast HCoV-229E human coronavirus human coronavirus 229E inactive inhibitor interfere lung cell normal NRTIs nucleoside nucleotide prodrug other coronaviruses parent Remdesivir RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 tested Treatment were used with HIV [DOI] 10.3390/molecules25102343 PMC 바로가기 [Article Type] Brief Report
Genetic diversity and ecology of coronaviruses hosted by cave-dwelling bats in GabonArticle Published on 2020-04-302022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activity alphacoronavirus Analysis association bat bats Betacoronavirus cave collected conducted coronavirus coronavirus 229E CoV CoV infection CoVs driving Ecology Factor FIVE Gabon HCoV-229E highlight Hipposidero Human Infection Microbiology Miniopterus non-human primate Prevalence Research rodents screened sequence significantly significantly higher wild animal wild animals zoonotic [DOI] 10.1038/s41598-020-64159-1 PMC 바로가기 [Article Type] Article
Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 DrugsArticle Published on 2020-04-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] age anti-SARS-CoV-2 approved bioinformatics common cold conditions coronavirus cough CoV COVID-19 CoVs disease drug drug resistance drugs drugs targeting Factor feasibility Fever HCoV-229E Health Human human CoVs humans infect inhibitors MERS-CoV Middle East mortality rate Mutation Nsp12 outbreak reported respiratory RNA RNA polymerase RNA polymerase inhibitor RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 drug sore throat therapeutic interventions threat Vaccine [DOI] 10.3390/pathogens9050320 PMC 바로가기 [Article Type] Article
Advances on Antiviral Activity of Morus spp. Plant Extracts: Human Coronavirus and Virus-Related Respiratory Tract Infections in the SpotlightArticle Published on 2020-04-182022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Morus spp. absence activity advance Analysis analyzed antiviral activities antiviral activity antiviral property Antiviral strategies coronavirus CPE crude extract cytopathogenic effect disease effective Epidemic evaluated exhibited HCoV 229E HCoV-229E hosts Human human coronavirus life-threatening Morus Alba offer Outbreaks picornavirus picornaviruses plant Poliovirus reduced representing respiratory respiratory infection respiratory viruses responsible specific treatment Therapies tract VAR viral infections viral pathogens viral titer [DOI] 10.3390/molecules25081876 PMC 바로가기 [Article Type] Article
The human coronavirus HCoV-229E S-protein structure and receptor bindingResearch Article Published on 2019-10-252022-10-31 Journal: eLife [Category] Coronavirus, [키워드] 229E aminopeptidase N class complex conformational change conserved coronavirus Coronaviruses Cross-species transmission crystal structure electron cryomicroscopy facilitated HCoV-229E host cell membranes hydrophilic immune evasion Interaction membrane fusion plasticity RBD Receptor binding Receptor binding domain S-protein sequence variation solvent specificity Spike protein Structure subunit interface virus X-ray X-ray crystallography [DOI] 10.7554/eLife.51230 PMC 바로가기 [Article Type] Research Article
Serological Screening for Coronavirus Infections in CatsArticle Published on 2019-08-132022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] addition Amino acid analyzed antibody antibody epitope antigenic Antisera cats Cell cell entry conserved coronavirus Coronavirus infection Coronaviruses CoV CoVs cross-reaction cross-reactivity Cross-species transmission diagnoses domain ELISA engage epidemic diarrhea Evidence excluded HCoV-229E human coronavirus 229E immunogenic indicated infect Infection mammal ortholog PEDV positive presence of antibody receptor Receptor binding reported S1 protein screened Screening sequence identity sera serological serum serum sample Spike protein subunit supported virus Virus neutralization widespread [DOI] 10.3390/v11080743 PMC 바로가기 [Article Type] Article
Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus–Host InteractionsArticle Published on 2019-08-132022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] airway epithelium Cell Cell culture Combined Culture cultures expression facilitate Factor fluorescence-activated cell sorting fluorescent functional Genetic hAEC HCoV-229E Host host gene expression Human human airway epithelial human airway epithelial cell cultures human coronavirus 229E human respiratory epithelium human respiratory virus in vitro inhibitor innate immune response Interaction knockdown lentiviral Modification modulated molecular not affected platform primary cell primary human cell Protein protocol reporter respiratory respiratory syncytial virus respiratory virus respiratory viruses target cells transgenic unique virus infection Virus-host interactions virus–host interaction Y-27632 [DOI] 10.3390/v11080747 PMC 바로가기 [Article Type] Article
Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus ReplicationArticle Published on 2019-01-162022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] approach arachidonic acid Cell cellular characterization clinical outcomes conserved coronavirus Coronavirus infection Coronavirus infections demonstrated elevated Fatty acid flu-like symptom function HCoV-229E highly pathogenic Host host cell Human human coronavirus 229E Infection inhibitory effect involved Lipid lipid metabolism Lipidomics Manifestations MERS-CoV metabolism Middle East modulate pathogenicity profile Regulation remodeling Replication respiratory syndrome coronavirus severe pneumonia significantly suggested suppressed UHPLC–MS understanding virus replication viruses [DOI] 10.3390/v11010073 PMC 바로가기 [Article Type] Article