Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patientsICU COVID-19 환자의 C3b/C4b 수용체(CR1, CD35) 획득 감소 및 적혈구의 C4d 침착 증가Article Published on 2021-05-012022-09-11 Journal: Immunobiology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Acquired Activation Activation factor assisted ventilation C3 C4 C4d capillary CD35 cell debris clearance Clinical severity coated complement Complement activation Course COVID-19 COVID-19 patient COVID-19 patients CR1 cumulative damage decrease disease endothelial erythrocyte erythrocytes Erythrocytes. France handling healthy individual healthy individuals highlight ICU immune complex immune pathophysiology individuals Inflammation innate immune response marker measurement mechanism observation organ Organ transplant parameter Participation pathophysiology Patient patients Protein receptor regulate Regulatory rejection reported SARS-CoV-2 SLE student t-test therapy transplant rejection Ventilation Virus spike were assessed [DOI] 10.1016/j.imbio.2021.152093 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection as a trigger of autoimmune response자가면역 반응의 촉발제로서의 SARS-CoV-2 감염Article Published on 2021-05-012022-09-12 Journal: Clinical and translational science [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome addition affected age All the patient analyzed antibodies antibody autoantibodies autoantibody Autoimmune Autoimmune disease Autoimmune response Autoimmunity blood donor C reactive protein clinical manifestations Clinical outcome clinician Concentration condition contribute coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 infection creatinine cytoplasmic de novo demonstrated drug ENhance enrolled evaluate Evidence explained ferritin healthy controls healthy individuals help heterogeneity Hypothesis immunoglobulin A Infection Inflammatory marker inflammatory markers lactate dehydrogenase marker neutralize outcome pathology Patient patients with COVID-19 plasma Prevalence Prognosis public health recent risk SARS-CoV-2 SARS-COV-2 infection screened shown stimulate the patient therapy to define transfer transferring treat viral disease with COVID-19 [DOI] 10.1111/cts.12953 PMC 바로가기 [Article Type] Article
Expression profiles revealed potential kidney injury caused by SARS-CoV-2: a systematic analysis of ACE2 and clinical lessons learned from this discovery발현 프로필은 SARS-CoV-2로 인한 잠재적인 신장 손상을 나타냈습니다: ACE2의 체계적인 분석 및 이 발견에서 얻은 임상 교훈Research Paper Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 ACE2 distribution ACE2 expression ACE2-positive cell ACE2-positive cells acute renal failure Admission Adults Analysis analyzed assessment assessments Blood urea nitrogen cause caused Cell city Clinical findings collected Collecting duct Comorbidities conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 positive patient creatinine Data analysis dataset EGFR elevated epithelial cells estimated glomerular filtration rate Evidence female filtration rate functions glomerular glomerular filtration rate healthy individuals hospital induce Infection infection site kidney kidney damage Kidney function Kidney injury kidney tissue Laboratory laboratory findings males nitrogen novel Novel coronavirus novel coronavirus disease organ organs pathophysiology Patient patients Pneumonia positive cells profile renal failure renal function reported retrospective RNAseq RNAseq data SARS-CoV-2 scRNA-seq data selected sequencing data serum creatinine single-cell Single-cell RNA sequencing systematic analysis the patient the SARS-CoV-2 Transcriptome transcriptome analysis urea urea nitrogen viral loads Wuhan Wuhan, China [DOI] 10.18632/aging.202224 PMC 바로가기 [Article Type] Research Paper
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal DiseaseClinical Trial Published on 2021-04-292022-10-04 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, [키워드] Activation Alter Asian association change Chronic kidney disease circulating Cohort complement Concentration contribute contributing to Control coronavirus COVID-19 COVID-19 severity COVID19 demonstrated determine dialysis healthy individuals host response impairment Infection Inflammation Innate immunity kidney lectin lectin pathway pathway Patient plasma plasma sample protease Protein severe COVID-19 severity susceptibility unique Variability white [DOI] 10.3389/fimmu.2021.671052 PMC 바로가기 [Article Type] Clinical Trial
Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cellsSARS-CoV-2에 감염된 환자의 폐 세포에서 조절되지 않는 비타민 D 내분비계의 증거Article Published on 2021-04-212022-09-10 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] affected Analysis applied BALF BALF cell BALF cells Bronchoalveolar lavage fluid Cell cell cycle cells computational approach Computational approaches conserved CYP27A1 cytokine signaling dataset differentially expressed differentially expressed gene Differentially expressed genes downregulated dysregulated eight elements Endocrine endocrine system Evidence evidence of Gene Expression Genes healthy individuals immune system indirect mechanism infected cells infected with SARS-CoV-2 Infection Interaction Level lung cell lung cells modulated motif NF-κB pathway Patient patients predicted provided receptor reduced Regulation retinoid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells Signaling status the cells transcriptomic transcriptomics Vitamin D vitamin D endocrine system Vitamin D receptor [DOI] 10.1038/s41598-021-87703-z PMC 바로가기 [Article Type] Article
Comparison of Serological Assays for the Detection of SARS-CoV-2 AntibodiesSARS-CoV-2 항체 검출을 위한 혈청학적 분석법의 비교Comparative Study Published on 2021-04-202022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] Antibody detection Antibody Response Antibody test antibody tests biosafety biosafety level Cohort Combination convalescent convalescent plasma coronavirus correlated strongly correlation COVID-19 COVID-19 patient cross-reactivity detect detection detection rate diagnostic discrimination Efficiency ELISA ENhance exposure to healthy individual healthy individuals hospital humans IgG IgG ELISA Infection infection with COVID-19 lentivirus neutralisation test neutralization positive provided pseudotype neutralisation Research SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 pseudotype virus SARS-CoV-2 virus SARS-CoV-2-N Screen sensitivities sensitivity serological serum severe disease spike glycoproteins utility Virus neutralisation VNT was performed [DOI] 10.3390/v13040713 PMC 바로가기 [Article Type] Comparative Study
From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 PathogenesisReview Article Published on 2021-04-162022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression Affect affected angiotensin-converting enzyme-2 antiviral immune responses axis bidirectional contribute cross-talk demonstrated dendritic cell Effect Efficacy expression gut microbiota composition healthy individuals homing Host immune response immune system infected with SARS-CoV-2 Inflammation lung lymphocyte main receptor microbiota outbreak Patient regulate reported respiratory infections responsible role SARS-CoV-2 shown the gut-lung axis Therapeutic approach Vaccine viral respiratory infection [DOI] 10.1155/2021/6611222 PMC 바로가기 [Article Type] Review Article
Systems serology detects functionally distinct coronavirus antibody features in children and elderlyArticle Published on 2021-04-012022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] Analysis antibodies antibody Antibody Response approach baseline change children circulating clinical outcomes Cohort coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccination Critical cross-reactive cross-reactivity detect diagnostics elevated Examining feature hallmark HCoV HCoVs healthy healthy children healthy individuals human coronavirus Humoral immunity IgA IgG immune response immunological responses induce Infection Mortality pathogenicity reactivity Receptor binding receptor engagement response resulting SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgM SARS-COV-2 infection serological serology System the antibody response viral infection virus [DOI] 10.1038/s41467-021-22236-7 PMC 바로가기 [Article Type] Article
Rapid Detection of COVID-19 Using MALDI-TOF-Based Serum Peptidome ProfilingMALDI-TOF 기반 혈청 펩티도메 프로파일링을 사용한 COVID-19의 신속한 검출Article Published on 2021-03-232022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] Accuracy analyzed build caused Clinical symptoms coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Data processing demonstrated detect detection Diagnosis diagnosis of COVID-19 eight False negative false negative result false negative results Feature selection flight global public health healthy individuals highest immunoassay infected individuals Logistic regression mass spectrometry non-COVID-19 patient outbreak pandemic patients PCR populations Profiling Rapid SARS CoV SARS CoV-2 sensitivity serum serum sample serum samples specificity Surveillance the disease Tuberculosis were used [DOI] 10.1021/acs.analchem.0c04590 PMC 바로가기 [Article Type] Article
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing엔지니어링된 CRISPR-Cas12a 변이체 및 DNA-RNA 하이브리드 가이드로 강력하고 신속한 COVID-19 테스트 가능Article Published on 2021-03-192022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] amplification Biochemical assays cause clinical sample clinical samples COVID-19 infection COVID-19 pandemic COVID-19 testing CRISPR CRISPR-Cas9 genome editing detect diagnostic DNA-RNA hybrid enzyme exhibit Extensive healthy individuals increase Infection Internal control LAMP Loop-mediated isothermal amplification microliter mutated Mutation nasopharyngeal patients with COVID-19 Positive predictive value Predictive value purified RNA reaction RNA purification robust SARS-CoV-2 sensitivity specificity specimen temperature transmission of SARS-CoV-2 variant variants Viral viral genome virus wildtype [DOI] 10.1038/s41467-021-21996-6 PMC 바로가기 [Article Type] Article