Evaluation of admission levels of P, E and L selectins as predictors for thrombosis in hospitalized COVID-19 patientsOriginal Article Published on 2022-01-212022-10-31 Journal: Clinical and experimental medicine [Category] COVID-19, MERS, 바이오마커, [키워드] Admission Anticoagulants Biomarker circulating clinical sensitivity Coagulopathy, P-selectin (CD62P) Complication controls coronavirus correlated COVID-19 COVID-19 patient COVID-19 patients death disease severity E-selectin E-selectin (CD62E) elevated ELISA endotheliopathy evaluate Factors feature healthy Hospital admission Hospitalization hospitalized COVID-19 patient identify independent predictor L-selectin (CD62L) laboratory biomarker P-selectin Patient platelets activation predict predicted predictor Prophylactic provided reported Retrospective study SARS-CoV-2 sensitivity significantly higher thrombosis [DOI] 10.1007/s10238-021-00787-9 PMC 바로가기 [Article Type] Original Article
Effects of Vitamin D and K on Interleukin-6 in COVID-19Nutrition Published on 2022-01-172022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] 25-hydroxyvitamin D administration arise association Biomarker circulating Clinical outcome clinical outcomes Combination correlated COVID-19 COVID-19 infection COVID-19 patients Degradation desmosine disease dp-ucMGP Effect excessive inflammatory response fiber hospitalized COVID-19 patient IL-6 IL-6 level IL-6 levels IMPROVE Inflammatory Inflammatory response Intervention matrix not significantly different outcome Patient Result significantly higher statistically significant Trial Vitamin D vitamin K [DOI] 10.3389/fnut.2021.761191 PMC 바로가기 [Article Type] Nutrition
Prognostic Factors for COVID-19 Hospitalized Patients with Preexisting Type 2 DiabetesResearch Article Published on 2022-01-172022-10-30 Journal: International Journal of Endocrinology [Category] COVID-19, [키워드] age analyzed build C-index chronic disease Clinical characteristics clinical factor clinician collected Complication Concordance COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients diabete diabetes medication died elevated evaluated Factor Glucose hospitalized COVID-19 patient identify independent insulin Intervention management medication Mortality multivariate Cox regression outcome Patient patients patients hospitalized performed Predictive Prognostic factor Prognostic factors provided reduce reduce mortality Result Retrospective study risk risk factor risk of death risk stratification SAA serum amyloid survival T2D Treatment Type with COVID-19 Wuhan, China [DOI] 10.1155/2022/9322332 PMC 바로가기 [Article Type] Research Article
Observational study of changes in utilization and outcomes in mechanical ventilation in COVID-19Observational Study Published on 2022-01-142022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] age analysed changes in Cohort comparable Confirmed COVID-19 COVID-19 case defined Endotracheal intubation Fund Hospital stay hospitalized COVID-19 patient IMV increased mortality intubation invasive Invasive mechanical ventilation male mechanical ventilation Mortality mortality rate NIV Non-invasive non-invasive ventilation observational study outcome overall mortality pandemic Patient patients treated proportion reduced Result second wave severe COVID-19 subsequent utilization was determined [DOI] 10.1371/journal.pone.0262315 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infectionSARS-COV-2는 무증상으로 가벼운 COVID-19 감염에 대한 내구성 및 항원 특이 적 체액 면역을 유도합니다.Research Article Published on 2022-01-122022-09-10 Journal: PLoS ONE [Category] 진단, 치료기술, 치료법, 치료제, [키워드] anti-Nucleocapsid IgG Anti-spike antibody antibody kinetics Antigen antigens asymptomatic to mild Characteristics COVID-19 COVID-19 infection current detectable discrepant results disease severity exhibited functional generate had no healthcare healthcare worker Healthcare workers hospitalized COVID-19 patient humoral Humoral immunity Humoral response induce longitudinal cohort study magnitude microneutralization Microneutralization assay mild symptoms neutralization capacity nucleocapsid protein participant Participants positive post infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike antigen serological Serological assay serological assays significantly higher Spike protein study inclusion study participant Study participants Support the SARS-CoV-2 the spike protein [DOI] 10.1371/journal.pone.0262169 PMC 바로가기 [Article Type] Research Article
Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’'SARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제한다'는 논평에 대한 응답Comment Published on 2022-01-112022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, [키워드] Analysis Anticoagulant bronchoalvelolar changes in Coagulation control patient COVID-19 COVID-19 patient fibrinolysis fibrinolytic Gene Expression hospitalized COVID-19 patient hospitalized COVID-19 patients Human lung Lungs pandemic procoagulant response SARS-CoV-2 SARS-CoV-2 pandemic Support suppresse the SARS-CoV-2 Transcriptome [DOI] 10.7554/eLife.74951 PMC 바로가기 [Article Type] Comment
Red Blood Cell Distribution Width in Hospitalized COVID-19 PatientsMedicine Published on 2022-01-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95%CI Absolute lymphocyte count acute respiratory syndrome age Anemia association body mass index caused chronic obstructive Clinical outcome confounder Coronary artery disease Coronavirus-2 COVID-19 COVID-19 patient defined Diabetes Mellitus Diseases elevated ferritin hospitalized COVID-19 hospitalized COVID-19 patient hypertension in-hospital mortality increased risk Lactate Length of stay LOS mechanical ventilation median morbidity and mortality Mortality outcome Prevalence Primary outcome pulmonary disease Red Red cell distribution width (RDW) remained risk SARS-CoV-2 Secondary outcomes Septic shock Sex significantly increased width [DOI] 10.3389/fmed.2021.582403 PMC 바로가기 [Article Type] Medicine
Clotting events among hospitalized patients infected with COVID-19 in a large multisite cohort in the United StatesResearch Article Published on 2022-01-052022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] anticoagulation arterial benefit blood clot clotting Cohort COVID-19 COVID-19 disease COVID-19 infection COVID-19 patients COVID-19 vaccine death diabetes event examined Factor Gender highlight hospital hospitalized COVID-19 patient hospitalized patient ICU illnesses increase increased risk infected with COVID-19 Infection Influenza influenza infection intensive care male material multisite Occurrence Older age patients hospitalized patients with COVID-19 progression rates of admission Result risk the United State thrombosis vaccination venous Venous thrombosis [DOI] 10.1371/journal.pone.0262352 PMC 바로가기 [Article Type] Research Article
Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses경증 COVID-19 환자의 바이러스 부하 해결은 선천 면역 반응 및 적응 면역 반응 모두와 관련이 있습니다Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술, [키워드] absence acute phase Adaptive immune response all the patients antibodies antibody Asymptomatic characterized circulating collected Comorbidities Comorbidity COVID-19 COVID-19 patient COVID-19 patients Cytokines detectable dysregulation Efficiency elevated Factor had no hospitalized COVID-19 patient Host IgG IL-1β IL-6 IL-7 IL-8 immune response implicated in viral increase in Inflammation Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators innate immune response interferon Kinetics marker mediators mild COVID-19 patient mild infection Mild symptom mild symptoms Most patient Most patients neutralize Neutralizing antibodies neutralizing antibody no increase over Patient PRNT Receptor-binding domain Resolution respiratory respiratory sample Respiratory samples Saliva saliva samples SARS-CoV-2 SARS-CoV-2 viral load Seroconversion serum serum samples severe COVID-19 strain swab samples Symptom T-cell activation the patient the receptor-binding domain These data TNF-α Viral Viral load Viral RNA viral RNA detection virus isolate Virus neutralization [DOI] 10.1016/j.jcv.2021.105060 PMC 바로가기 [Article Type] Article
Use of steroids in COVID-19 patients: A meta-analysisResearch article Published on 2022-01-012022-10-05 Journal: European journal of pharmacology [Category] SARS, 신약개발, 임상, [키워드] 95% confidence interval Alter Analysis association benefit calculated clinical clinical evidence COVID-19 COVID-19 patient COVID-19 patients death deaths Dexamethasone drugs exclusion criteria Google hospitalized COVID-19 patient Hydrocortisone Inclusion Man Meta-analysis Methylprednisolone Odds ratio Patient Physicians Quantitative analysis reduce reduction in required Result searched sensitivity sensitivity analysis shown steroid Steroids subgroup analysis The Rev Trial use of steroid was done was used [DOI] 10.1016/j.ejphar.2021.174579 [Article Type] Research article