Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial성인 외래 환자의 covid-19 치료를 위한 흡입 및 비강 ciclesonide: CONTAIN 2상 무작위 대조 시험Clinical Trial Published on 2021-11-022022-09-11 Journal: The BMJ [Category] 임상, [키워드] 95% confidence interval adjusted adult outpatient adult outpatients assigned benefit Chain Reaction Ciclesonide Combination Comorbidities conducted control group Corticosteroid Corticosteroids cough determine dose double blind Dyspnoea Evidence Fever Follow-up increase in Inhaled interquartile range intervention group intranasal median age modified intention-to-treat nasal not differ Older outcome participant Placebo placebo controlled trial polymerase chain polymerase chain reaction presenting Primary outcome proportion randomisation randomised randomised controlled trial Randomly receive Research resolution of symptom respiratory symptom respiratory symptoms Result risk risk difference saline placebo Sex significantly statistically significant stratified study drug symptom resolution treat treatment of COVID-19 Trial women [DOI] 10.1136/bmj-2021-068060 PMC 바로가기 [Article Type] Clinical Trial
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters홍역 매개 코로나19 생백신은 생쥐와 햄스터에서 SARS-CoV-2 공격으로부터 강력한 면역과 보호를 유도합니다Article Published on 2021-11-012022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] Adenovirus animals antibody Antibody titers Antigen approach circulating variant circulating variants Coverage COVID-19 vaccine develop Efficacy elicited expressing full-length S generate hamster hamsters Immunity immunogenicity in vitro induce intranasal Live attenuated vaccines measles vaccine measles virus Messenger RNA mice neutralization neutralize neutralizing antibody titers pandemic pediatric prefusion PROTECT response SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 vaccine SARSCoV-2 Spike protein T-cell Response T-cell responses tested the SARS-CoV-2 Vaccine variants viral infection world population [DOI] 10.1038/s41467-021-26506-2 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challengeArticle Published on 2021-10-282022-10-04 Journal: NPJ Vaccines [Category] 비임상, [키워드] Administered animal Antibody Response Antibody titer B.1.1.7 B.1.351 B.1.351 variant Beta comparable Coverage disease dose evaluated evidenced ferritin Formulation groups hamster High dose intranasal intranasally low-dose lung Lung pathology nasal PROTECT Protective Protein vaccines reduced regimens SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 variant Support Syrian Golden hamsters vaccination Vaccinations Vaccine variant viral burden viral infection viral replication virus VoC WA1 weight loss [DOI] 10.1038/s41541-021-00392-7 PMC 바로가기 [Article Type] Article
Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques붉은 털 원숭이의 비강 및 기관 내 SARS-CoV-2 감염에 대한 위장 SARS-CoV-2 전달의 보호 효능Vaccines and Antiviral Agents Published on 2021-10-272022-09-12 Journal: Journal of Virology [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus administration Antibody titer Bronchoalveolar lavage fluid challenge conducted coronavirus correlated Coverage COVID-19 delivery distribution Efficacy esophagogastroduodenoscopy Formulation Gastrointestinal gastrointestinal tract greater health benefits immunogenic immunogenicity intranasal intratracheal live oral vaccine Live oral vaccines live SARS-CoV-2 macaque mucosal nasal swab nasal swabs offer oral administration Oral vaccine Prophylactic Protective protective efficacy public health Rectal swabs respiratory viruses rhesus macaque rhesus macaques route SARS-CoV-2 serotype Serum neutralizing antibody severe acute respiratory syndrome Coronavirus timelines Vaccine Vaccines Viral load virus replication [DOI] 10.1128/JVI.01599-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice새로운 형질전환 마우스에서 렌티바이러스 백신에 의한 SARS-CoV-2 변이체에 대한 뇌 교차 보호Article Published on 2021-10-252022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, 진단, [키워드] accumulated addition angiotensin boost Brain caused Central nervous system clinical development COVID‐19 demonstrated displaying Efficacy elicit enzyme expressing Gamma hACE2 transgenic mice Immunity immunology induce intramuscular intranasal intranasal vaccination lentiviral lung mechanism Microbiology, Virology & Host Pathogen Interaction Mutation mutations neurological Neutralizing antibodies olfactory bulb P.1 PROTECT Protective reduced Replication robust SARS‐CoV‐2 SARS‐CoV‐2 emerging variants of concern spike glycoprotein T‐cell the vaccine transgenic mice transgenic model Transgenic mouse Vaccine vaccine candidate variant variants virus [DOI] 10.15252/emmm.202114459 PMC 바로가기 [Article Type] Article
Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2중증 급성 호흡기 증후군 코로나 바이러스로 감염된 노인 햄스터의 비정상적인 혈액 응고 및 신장 손상 2Article Published on 2021-10-222022-09-01 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] abnormality acute kidney acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age aged Syrian hamster animal model animal models Blood coagulation cause Coagulation coagulation factor Coagulation factors Consumption coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 research damage demonstrated disease stages groups hamster Infection Inflammatory response Inflammatory responses intranasal intravascular coagulation investigated kidney kidneys lack lung Lungs male mesangial matrix Mortality Pathogenesis Patient patients Pneumonia prothrombin Prothrombin time proximal respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity Symptom systemic systemic symptoms tissue damage Urinary tract Viral viral replication [DOI] 10.3390/v13112137 PMC 바로가기 [Article Type] Article
A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration강력한 이중특이성 나노바디는 비강 투여를 통해 SARS-CoV-2 감염으로부터 hACE2 마우스를 보호합니다Article Published on 2021-10-192022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration albumin alpaca bispecific circulating SARS-CoV-2 variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta delta variant effective Efficacy exhibit hACE2 hACE2 mice Human serum albumin immunized IMPROVE in vivo intranasal Live virus mice nanobody Nb15 Nb15-NbH-Nb15 neutralization potency Neutralizing potent neutralizing. Prophylactic PROTECT provide Pseudotyped viruses RBD of SARS-CoV-2 Receptor binding domain respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike glycoprotein therapeutic purpose therapeutic strategy transgenic treating COVID-19 Treatment trimer VHH wild-type [DOI] 10.1016/j.celrep.2021.109869 PMC 바로가기 [Article Type] Article
Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary EvidenceCOVID-19 관리에서 항바이러스제로서의 락토페린: 예비 증거Article Published on 2021-10-192022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료제, [키워드] added adverse event adverse events Analysis antiviral activity Antiviral effect Asymptomatic Asymptomatic COVID-19 bovine bovine lactoferrin cationic clinical symptom conducted COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients D-dimer D-dimers exocrine gland exocrine glands ferritin glycoprotein healthy subject Hospitalized hospitalized patient IL-6 in vitro in vivo intranasal Isolation lactoferrin liposomal bovine lactoferrin management medication Mild-to-moderate multifunctional Negative conversion Neutrophils observation Patient patients recruited reported SARS-CoV-2 SARS-CoV-2 RNA Serum ferritin significant decrease Standard of care three groups treated [DOI] 10.3390/ijerph182010985 PMC 바로가기 [Article Type] Article
Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19Pharmacology Published on 2021-10-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Anu AYUSH board Body weight loss characterized coronavirus coronavirus disease COVID-19 cytokine Effect exhibited expression Formulation Genes hamster Herbal histopathological indicated Infection inhibiting initiate intranasal lung Lung pathology Model molecular analysis mRNA expression Oil plant pro-inflammatory cytokine Prophylactic provided Pulmonary pathology reduced reduction in Respiratory failure SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection severity Th1 Th17 upper respiratory tract viral entry Viral load virus [DOI] 10.3389/fphar.2021.746729 PMC 바로가기 [Article Type] Pharmacology
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset증상 발병 전 인플루엔자 및 감기를 감지하기 위해 비침습적 웨어러블 생체 모니터링 센서를 사용하는 것의 타당성 평가Research Published on 2021-09-292022-09-25 Journal: JAMA Network Open [Category] Fulltext, 신종인플루엔자, 임상, 진단, [키워드] 24 hour Accuracy age Analysis assessment AUC Can characteristic chronic respiratory Cohort cohort study Cold collected common conducted Contagion COVID-19 criteria Culture detect evaluate exposure feasibility feasible finding General population H1N1 H1N1 influenza help Human rhinovirus identify Importance individual Infection infectious dose Influenza inoculated Intervention intranasal limit measure men Mild moderate monitoring noninvasive objective Onset participant Patient Performance metrics Point Precision predict presymptomatic prevent disease spread primary outcome measure random recruited Relevance resource respiratory virus Result rhinovirus screening method sensitivity sensor Separate serum antibodies setting severity specificity Spread strain type Support Symptom symptom onset TCID50 the median tissue took place trajectory viral challenge viral infection viral respiratory infection viral respiratory infections virus [DOI] 10.1001/jamanetworkopen.2021.28534 PMC 바로가기 [Article Type] Research