Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital뉴욕시 병원에서 COVID-19 위기 동안 2차 감염을 유발하는 Carbapenemase 생성 EnterobacteralesArticle Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] Antibiotic resistance antibiotic resistance gene Bacterial infections Clinical characteristics collected COVID-19 crisis COVID-19 patients CPE Culture declined Enterobacter cloacae complex genotyping global pandemic hospital Illumina Increased increased risk isolate isolates Klebsiella pneumoniae KPC Lineage MDR mechanism mitigate MOST Most patient Most patients Nanopore nanopore sequencing New York City pathogen Pathogens Patient patients patients with COVID-19 Phylogenetic analysis pneumoniae positive Prevalence respiratory SARS-CoV-2 secondary bacterial infection Secondary bacterial infections Secondary infection secondary infections Sequencing sequencing data Surveillance Treatment treatment approach treatment failure wake WGS while with COVID-19 [DOI] 10.1093/jac/dkaa466 PMC 바로가기 [Article Type] Article
Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2COVID-19 환자의 비인두 샘플 전사체 및 다른 SARS-CoV-2 감염 모델과의 비교 분석은 SARS-CoV-2에 대한 이질적인 숙주 반응을 보여줍니다Comparative Study Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 유전자 메커니즘, [키워드] ACE2 Analysis Antigen presentation Apoptosis Atf3 CCL2 CCL4 CCR1 COVID-19 COVID-19 patient CXCL2 cytokine cytokine signaling disparate DPP4 effective enrichment analysis exhibited expressed expression feature Functional enrichment analyses GATA6 Genome variations genomic HDAC2 Host host response Host transcriptional response host transcriptome hypoxia IFN IL1A IL6 immune immune response immune system incorporation induction of apoptosis Innate immunity integrin Integrins interferon Invasion isolates ITGA2B ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAE ITGAV ITGB3 ITGB7 lung Lung injury Lungs Missense mutation nasopharyngeal cells nasopharyngeal sample Nasopharyngeal samples NFAT non-structural protein overexpression Pathogenesis patients progression protease reported response Result SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection TCF12 transcription factor transcription factors Transcriptome upregulation Viral viral pathogenesis Viral protein Viral proteins virus [DOI] 10.1186/s12967-020-02695-0 PMC 바로가기 [Article Type] Comparative Study
European context of the diversity and phylogenetic position of SARS-CoV-2 sequences from Polish COVID-19 patientsMicrobial Genetics • Original Paper Published on 2021-01-052022-10-30 Journal: Journal of applied genetics [Category] COVID-19, SARS, [키워드] affecting Analysis carried change circulating clade Cluster comprehensive analysis coronavirus COVID-19 COVID-19 patient dataset DNA Epidemiology European examined explained favor Frequency GISAID database GISAID sequences Haplotype haplotypes homoplasies increase in independent isolate isolates local outbreaks majority multidimensional Multiple mutations New performed Phylogenetic Phylogenetic analysis phylogenetics Poland Population Prevalence Recombination reflect SARS-CoV-2 SARS-CoV-2 sequence sequence strain Strains subset the SARS-CoV-2 transfer Variability variant variety viral genome Whole RNA genome sequencing whole-genome [DOI] 10.1007/s13353-020-00603-2 PMC 바로가기 [Article Type] Microbial Genetics • Original Paper
Variant analysis of the first Lebanese SARS-CoV-2 isolates최초의 레바논 SARS-CoV-2 분리주의 변종 분석Article Published on 2021-01-012022-09-11 Journal: Genomics [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid Analysis blastx codon coronavirus Frame Genome genome sequence help identify Infection isolates Lebanese isolates Missense Missense mutation Mutation novel Novel mutations Nsp3 nsp4 ORF1 ORF1ab ORF3a reported respiratory SARS-CoV-2 coronavirus SARS-CoV-2 isolate sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein spike protein S2 STOP stop codon Strains the SARS-CoV-2 the spike protein variant variants variations was performed [DOI] 10.1016/j.ygeno.2020.10.021 PMC 바로가기 [Article Type] Article
Emergence of Novel Reassortant H1N1 Avian Influenza Viruses in Korean Wild Ducks in 2018 and 2019Article Published on 2020-12-262023-05-25 Journal: Viruses [Category] 신종인플루엔자, 조류인플루엔자, 핵심논문, [키워드] Avian Influenza H1N1 isolates mammal adaptation Pathogenesis [DOI] 10.3390/v13010030 PMC 바로가기 [Article Type] Article
Comparison of Rapid Antigen Tests for COVID-19COVID-19에 대한 신속한 항원 검사의 비교Comparative Study Published on 2020-12-102022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 can not clinics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient detect diagnose Diagnosis examined Infectious virus isolate isolates Isolation lateral flow immunoassay Lateral flow immunoassays Local PCR positive quantitative PCR Rapid rapid antigen test Rapid antigen tests RAT RATs respiratory reverse transcription RT-qPCR SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus specimen Test tested Viral Viral antigen viral antigens virus [DOI] 10.3390/v12121420 PMC 바로가기 [Article Type] Comparative Study
A rapid, cost-effective tailed amplicon method for sequencing SARS-CoV-2SARS-CoV-2 시퀀싱을 위한 빠르고 비용 효율적인 테일 앰플리콘 분석법Methodology Article Published on 2020-12-042022-09-01 Journal: BMC Genomics [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] amplicon method applied approach approaches balance bypasse capture comparable costly Coverage COVID-19 COVID-19 pandemic diagnostics Genome Genome sequencing genomic isolate isolates labor metagenomic Metrics protocol Result SARS-CoV-2 SARS-CoV-2 sequencing sequence sequenced Sequencing sequencing technology Surveillance time-consuming variant call variant calls Viral Viral surveillance [DOI] 10.1186/s12864-020-07283-6 PMC 바로가기 [Article Type] Methodology Article
First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel RegionArticle Published on 2020-11-022022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Analysis caused China clade coronavirus country Diversity effort Human independent insight isolates Mali pandemic pandemic of COVID-19 Patient Phylogenetic analysis positive Region Sahel SARS-CoV-2 Screening sequence Sequencing sequencing data spread to virus WGS whole genome whole genome sequence Wuhan [DOI] 10.3390/v12111251 PMC 바로가기 [Article Type] Article
Vaccine design based on 16 epitopes of SARS‐CoV‐2 spike proteinResearch Article Published on 2020-11-012022-11-01 Journal: Journal of medical virology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Amino acid Analysis antigenic biological activity coronavirus Coverage Cytokines database effective epitope Epitopes GPGPG HLA molecule IEDB immunoinformatics immunological in silico induce isolates linker mutated Mutation non‐synonymous mutation nontoxic outbreak pentapeptide peptide polymorphism populations predicted Protein provided recognize Research SARS‐CoV‐2 SARS‐CoV‐2 screened secretion sequence Spike protein suggested T‐cell the spike protein translated Vaccine vaccine candidate [DOI] 10.1002/jmv.26596 PMC 바로가기 [Article Type] Research Article
Aprotinin Inhibits SARS-CoV-2 Replication아프로티닌은 SARS-CoV-2 복제를 억제합니다Article Published on 2020-10-302022-09-11 Journal: Cells [Category] MERS, SARS, 진단, 치료제, [키워드] 2019-nCoV acute respiratory syndrome air–liquid interface Alpha Analysis Anti-SARS-CoV-2 Activity Antiviral approved Aprotinin Caco2 Calu Calu-3 Cell cell type cell types cellular proteases cleavage Concentration concentrations coronavirus coronavirus disease COVID-19 COVID-19 progression cultures disease downregulated downregulation Drug discovery epithelial epithelial cell host cell host cell protease host cell proteases indicated inhibited inhibitor isolates Local local control pandemic Prevent prevention of COVID-19 progression Protease inhibitor protease inhibitors Protein proteomics respiratory SARS-CoV-2 SARS-CoV-2 replication SERPINA1 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome virus systemic disease therapeutic virus virus entry virus replication [DOI] 10.3390/cells9112377 PMC 바로가기 [Article Type] Article