An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19인간 A549 폐 세포의 자가항원 프로필은 COVID-19에서 자가면역의 바이러스 및 숙주 병인 분자 특성을 나타냅니다Article Published on 2021-06-012022-09-12 Journal: Journal of autoimmunity [Category] MERS, SARS, 진단, [키워드] A549 A549 cells activating Affect alteration alterations Apoptosis atlas attribute autoantibodies autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmunity biogenesis caused CDK11A cellular changes in COVID COVID-19 degranulation Gene Expression Host human lung IL-12 immune responses induce lung lung cell membrane mitochondrial ribosomal proteins mitochondrial ribosome modify molecular mRNA metabolism NSP Platelet PLD3 PRKDC Protein provide PSAT1 RAB1A resource Resource. reveal ribonucleoprotein SARS-COV-2 infection Signaling significantly SLC2A1 target transcript translation Transport UBA1 UCHL1 unique USP7 Vesicle viral infection Viral protein viral replication [DOI] 10.1016/j.jaut.2021.102644 PMC 바로가기 [Article Type] Article
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohortObservational Study Published on 2021-05-252022-10-04 Journal: Critical Care [Category] 임상, [키워드] 28-day mortality 95% CI adjusted Analysis clinical Cohort competing COVID-19 criteria determine diagnosed discharge European evaluated event Evidence extubation finding group groups heterogeneity higher risk ICU ICU admission Influenza influenza pneumonia mechanical ventilation modify Mortality multicenter multivariable not different outcome patients populations Quantitative radiological Registered regression models relationship retrospective risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 pneumonia significant difference significantly significantly higher significantly increased study groups supplementary material the SARS-CoV-2 Trial registration VAP Ventilator-associated pneumonia viral infection were used [DOI] 10.1186/s13054-021-03588-4 PMC 바로가기 [Article Type] Observational Study
Promoting Mental Health of Nurses During the Coronavirus Pandemic: Will the Rapid Deployment of Nurses’ Training Programs During COVID-19 Improve Self-Efficacy and Reduce Anxiety?Psychiatry Published on 2021-05-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] age Analysis Anxiety Care chi-square test conducted coronavirus disease Course COVID-19 COVID-19 pandemic COVID-19 patient determinant determine Factor GAD-7 Generalized GSE handling hospital identify IMPROVE independent lack Managing Anxiety mental health modify multivariable Nurse Nurses pandemic Pandemics predictor Program Promoting quarantine Rapid reducing regression analysis Result Self-efficacy training was performed were used [DOI] 10.7759/cureus.15213 PMC 바로가기 [Article Type] Psychiatry
Dolosigranulum pigrum Modulates Immunity against SARS-CoV-2 in Respiratory Epithelial CellsCommunication Published on 2021-05-212022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Dolosigranulum pigrum Activation addition Administered Calu-3 cell CCL5 cellular damage combating commensal bacteria coronavirus coronavirus 2 Coronavirus infection COVID-19 culture supernatant CXCL10 CXCL8 cytokine profile demonstrated evaluate IFN-β IL-6 Immunity immunological mechanism immunomodulatory effect IMPROVE innate immune response involved mice modify modulated modulation next generation probiotics reducing reduction in respiratory respiratory commensal bacteria respiratory epithelial cell respiratory epithelial cells RSV SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 stimulated strain TLR3 Toll-like receptor 3 triggered viral replication [DOI] 10.3390/pathogens10060634 PMC 바로가기 [Article Type] Communication
COVID-19’s natural course among ambulatory monitored outpatients외래 모니터링 외래 환자의 COVID-19 자연 경과Observational Study Published on 2021-05-122022-09-10 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, [키워드] Ageusia Algorithm Anosmia Asymptomatic average Cohort Comorbidities Complication Course COVID-19 symptom diagnosed diagnostics disease Epidemiology evaluated fevers Follow-up Genetic testing Government group highest highlight Hospitalized indicated initial symptom Intensive Lifestyle modification mass education median medical condition modify negative sample negative test no symptom no symptoms occurred Outpatient outpatients Patient Patient education patients PCR PCR negativity Population screening Preventive medicine proliferation quarantine Regulation reported respiratory Respiratory distress syndrome Respiratory signs and symptoms Risk factors SARS-CoV-2 significantly subsequent Symptom symptom onset symptom status symptomatic Symptoms the disease trajectory Variability Viral viral infection Viral load [DOI] 10.1038/s41598-021-89545-1 PMC 바로가기 [Article Type] Observational Study
Ultraviolet light-induced collagen degradation inhibits melanoma invasionArticle Published on 2021-05-122022-10-04 Journal: Nature Communications [Category] 변종, [키워드] arising Biomarker Cancer cancer cell Cancer microenvironment cancers Cell Col1a1 collagen contribute death Degradation degrade ECM expressing expression Extracellular matrix fibroblast Gene Expression Human IMPROVE incidence increase inhibit inhibiting Invasion invasive less Local Melanoma MMP1 modify outcome predictor Prognosis reduced reducing restored robust Single Cell survival Ultraviolet radiation [DOI] 10.1038/s41467-021-22953-z PMC 바로가기 [Article Type] Article
The relative power of individual distancing efforts and public policies to curb the COVID-19 epidemicsResearch Article Published on 2021-05-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] adjust Asymptomatic average aversion calibration communication Contact COVID-19 death debate effective effort Epidemic Epidemics equilibrium French Hospitalization Impact incidence include increase individual infection risk interact lockdown modify Mortality physical distancing Prevalence Public public policy question reduction Regulation risk Spread the epidemic Transmission utility [DOI] 10.1371/journal.pone.0250764 PMC 바로가기 [Article Type] Research Article
Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contributionReview Article Published on 2021-05-062022-10-31 Journal: Mucosal Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] adipocyte adipocytes Altered Cell cellular metabolism contributing to Cytokine storm disease dysregulated Evidence H1N1 influenza hyperinflammation Immune cell immune response immune system imperative independent risk factor individuals Infection infections Infectious disease Inflammation Inflammatory inflammatory properties Influenza mechanism metabolism modify modulation obese obesity Pandemics Pathogenesis pathogenic Pneumonia Premature Prevalence SARS-CoV-2 SARS-COV-2 infection severity susceptibility viral respiratory [DOI] 10.1038/s41385-021-00404-8 PMC 바로가기 [Article Type] Review Article
Population Dynamics and Structural Effects at Short and Long Range Support the Hypothesis of the Selective Advantage of the G614 SARS-CoV-2 Spike VariantG614 SARS-CoV-2 스파이크 변형의 선택적 이점에 대한 가설을 뒷받침하는 근거리 및 장거리 인구 역학 및 구조적 효과Article Published on 2021-05-042022-09-11 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] affecting clinical samples coalescent-based inference conformational connection country domain drugs Dynamics Effect Epidemics explain explained Frequency functional furin G614 variant generalized linear mixed models genomic variant genomic variants Hypothesis increase infections information invasive linear Long Modification modify molecular molecular dynamics molecular dynamics simulations plasticity Population Population dynamics propagule proteolytic Range reached Receptor-binding domain S1/S2 SARS-CoV-2 SARS-CoV-2 evolution selective spike Spike protein Spread statistical analyses Support the receptor-binding domain the spike protein Transmission variant virus [DOI] 10.1093/molbev/msaa337 PMC 바로가기 [Article Type] Article
Point-of-care faecal calprotectin testing in patients with paediatric inflammatory bowel disease during the COVID-19 pandemicCOVID-19 전염병 동안 소아 염증성 장 질환 환자의 현장 진료 대변 칼프로텍틴 검사Article Published on 2021-05-012022-09-11 Journal: BMJ open gastroenterology [Category] 바이오마커, [키워드] alternative automatically benefit bowel calprotectin change Clinical management COVID-19 pandemic Crohn's disease decision Disruption had no help home hospital IBD Inflammatory Inflammatory bowel disease Laboratory test Laboratory testing Laboratory tests less management modify offer Patient patients portal produced questionnaire reduce required Stool stool markers ulcerative colitis user [DOI] 10.1136/bmjgast-2021-000631 PMC 바로가기 [Article Type] Article