Assessment of humoral and cellular immune responses to SARS CoV-2 vaccination (BNT162b2) in immunocompromised renal allograft recipients면역 저하된 신장 동종이식 환자에서 SARS CoV-2 백신(BNT162b2)에 대한 체액 및 세포 면역 반응 평가Article Published on 2022-04-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence Allograft Assessing assessment belatacept BNT162b2 booster vaccinations both groups CD4+ CD8+ T-cell Cellular immune response controls Critical cytomegalovirus deficiencies demonstrated dose Efficacy examined healthy controls humoral IgG IgG response IgG responses immune immune response immune responses Immunocompromised immunosuppressive in both group individual Infection ISP kidney kidney transplant limit memory MMF mycophenolate mycophenolate mofetil no differences of BNT162b2 partial immunity Patient patients peptide peptides Pfizer Prednisone preventing infection protective immunity protocol recipient renal response responses SARS CoV-2 SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe deficiency severity shown spike spike IgG T-cell T-cell immunity T-cell Response T-cell responses tacrolimus vaccination Vaccine [DOI] 10.1111/tid.13813 PMC 바로가기 [Article Type] Article
Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant by Immunized Individuals면역화된 개인에 의한 SARS-CoV-2 오미크론 변이체에 대한 T 세포 반응성 평가Article Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] age assessment blood sample Blood samples Care CD4+ cell CD4+ cells CD4+ T cell CD4+ T cells CD8+ T cells Cell cellular component cellular immunity cohort study conducted contagious decrease determine enrolled foundation Frequency full-length protein group Health Health care highlight Hospitalization immune immune protection immune system Immunity immunized individual Infection Italy Lymphocytes median mutated Mutation Neutralizing new SARS-CoV-2 no significant differences omicron Omicron variant outcome participant peptide peptides reactive reactivity reduced reduction Region regions Rome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera severe disease significant difference significantly Spike protein Stimulation T cells T-cell T-cell immunity tested the SARS-CoV-2 the spike protein vaccination variant variant of SARS-CoV-2 Volunteer volunteers women [DOI] 10.1001/jamanetworkopen.2022.10871 PMC 바로가기 [Article Type] Article
In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape새로운 SARS-CoV-2 계통에서 돌연변이 에피토프의 실리코 분석은 전 세계적으로 향상된 CD8+ T 세포 반응성과 면역 반응 탈출의 징후를 시사합니다Article Published on 2022-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Analysis antibody B.1.1.7 B.1.351 binding Binding prediction Brazil CD8+ CD8+ T cell CD8+ T cell response CD8+ T cells change class Class I HLA conserved country Coverage COVID-19 E484K epitope Epitopes evade Evidence exhibiting expected fraction highlight HLA allele HLA alleles HLA binding immune response immunogenic in silico individual investigated Lineage lineages mutant Mutation N501Y new SARS-CoV-2 P.1 P.2 peptide peptides predicted provided reactivity reference sequence respond response SARS-CoV-2 SARS-CoV-2 variants silico predictions South Africa spike T cell T cell epitopes T cells TCR Transmissibility variant variants variants of concern Viral load [DOI] 10.1016/j.meegid.2022.105236 PMC 바로가기 [Article Type] Article
Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine DesignSARS-CoV-2 백신 디자인을 위한 후보 T-세포 에피토프를 예측하기 위한 컴퓨터 기반 면역정보 분석Article Published on 2022-03-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity allele Antigen B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 binding free energy Brazil candidate caused change Chinese clinical trial collected coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 effective epitope Epitopes evaluated Evidence experimental validation free energy HLA HLA-A human leukocyte antigen immune mechanism IMPROVE Inclusion India less leukocyte molecular molecular docking mutate mutated Mutation neutralizing antibody New outbreak overlapping P.1 pandemic peptide peptides predict predicted Prevalence problem residue S protein S-protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection selected severe acute respiratory syndrome Coronavirus South Africa Spike protein strain T-cell T-cell epitopes therapy United Kingdom Vaccine Vaccine design Vaccine development Vaccines virus virus genomes virus infection was used [DOI] 10.3389/fimmu.2022.847617 PMC 바로가기 [Article Type] Article
Diagnostic and Therapeutic Potential for HNP-1, HBD-1 and HBD-4 in Pregnant Women with COVID-19COVID-19에 감염된 임산부에서 HNP-1, HBD-1 및 HBD-4에 대한 진단 및 치료 가능성Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] affected Alpha AMPs anti-inflammatory cytokine antimicrobial peptide antimicrobial peptides Beta Biochemistry biological activities characterized Coagulation Confirmed COVID-19 infection COVID-19 COVID-19 infection cytokine cytokine profile Cytokines defensin Defensins deficiency defined ELISA assay evaluated fetus Gene Expression generate help highlight IL-10 IL-2 IL-6 IL-8 immune immune system immunological change increase in Infection innate immune system Interleukins involved Laboratory Laboratory medicine lipoprotein lipoprotein-a mechanism mother peptides Potential Pregnancy pregnant women pro-inflammatory factor pro-inflammatory factors problem problems PROTECT risk factor TGF-β TNF-α virus attacks Vitamin vitamins with COVID-19 [DOI] 10.3390/ijms23073450 PMC 바로가기 [Article Type] Article
Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19치명적인 COVID-19의 조기 예측을 위한 바이오마커로서의 면역원성 SARS-CoV-2 S 및 N 단백질 펩티드 및 사이토카인 조합Article Published on 2022-03-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, 치료법, [키워드] Activation analyzed Biomarker Biomarkers chemokines clinical outcomes convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sera cytokine Cytokine activation Cytokines demonstrated difference fatal fatal COVID-19 fatality higher risk highest humoral immune response IgG IgM IgM antibody improve clinical outcomes indication knowledge likelihood longitudinal analysis marker N protein nucleocapsid Nucleocapsid phosphoprotein Patient peptide peptides prediction pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines quantified reactivity risk S protein SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S selected serum serum sample serum samples severe coronavirus disease Surface glycoprotein Treatment [DOI] 10.3389/fimmu.2022.830715 PMC 바로가기 [Article Type] Article
Protocol for global proteome, virome, and metaproteome profiling of respiratory specimen (VTM) in COVID-19 patient by LC-MS/MS-based analysisLC-MS/MS 기반 분석을 통한 COVID-19 환자의 호흡기 표본(VTM)의 글로벌 프로테옴, 바이롬 및 메타프로테옴 프로파일링을 위한 프로토콜Article Published on 2022-03-182022-09-11 Journal: STAR protocols [Category] SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Analysis Bacterial Bioinformatics analysis Complete COVID-19 patient COVID-19 patients digestion downstream H1N1 H1N1 patients Health Sciences High-resolution Host include Major mass mass spectrometry Patient peptides Protein proteome proteomics protocol provided quantification specimen virus inactivation VTM with COVID-19 [DOI] 10.1016/j.xpro.2021.101045 PMC 바로가기 [Article Type] Article
Evaluation of Spike Protein Epitopes by Assessing the Dynamics of Humoral Immune Responses in Moderate COVID-19중간 정도의 COVID-19에서 체액 면역 반응의 역학을 평가하여 스파이크 단백질 에피토프 평가Article Published on 2022-03-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] AbMap acute respiratory syndrome analyses Analysis antibody binding epitope Antigen Assessing caused change Characteristics Cohort comparable Comprehensive conserved coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diagnosis distribution domains Dynamics ELISA enzyme-linked immunosorbent epitope genomic region homotrimer Hospitalization Hospitalized host immunity humoral humoral immune response IgG IgG antibody IgM immune immune system Immunotherapy in viral Infection information Microarray Moderate COVID-19 Novel coronavirus pandemic Patient peptide peptide microarray peptides provided random reactivity recombinant response S protein S protein epitope S proteins S1 protein SARS-CoV-2 serum sample Seven spike spike gene sequence Spike protein suggested symptom onset the S protein Vaccine development were used [DOI] 10.3389/fimmu.2022.770982 PMC 바로가기 [Article Type] Article
Matrix-Assisted Laser Desorption and Ionization Time-of-Flight Mass Spectrometry Analysis for the Direct Detection of SARS-CoV-2 in Nasopharyngeal Swabs비인두 면봉에서 SARS-CoV-2의 직접 검출을 위한 매트릭스 보조 레이저 탈착 및 이온화 비행 시간 질량 분석 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid anion exchange resin biological molecule biological molecules cartridge Chain Reaction Combination complex contagious coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients detect detection Diagnostic method digested Direct Evidence flight identify in some inoculated ionization labor-intensive Laser limit of detection mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab specimen Nasopharyngeal swab specimens nasopharyngeal swabs nucleocapsid patients PCR peptide peptides polymerase chain polymerase chain reaction positive result purification purified Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription reverse transcription polymerase chain reaction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARS-CoV-2-specific peptide SARS-CoV-2-specific peptides selected separated Seven severe acute respiratory syndrome Coronavirus specimen specimens Spectrometry Swab the SARS-CoV-2 trypsin Viral load was performed [DOI] 10.1021/acs.analchem.1c04328 PMC 바로가기 [Article Type] Article
Long Lasting Cellular Immune Response Induced by mRNA Vaccination: Implication for Prevention StrategiesmRNA 백신 접종으로 유도된 오래 지속되는 세포 면역 반응: 예방 전략에 대한 시사점Article Published on 2022-03-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Administered B lymphocyte B lymphocytes BNT162b2 BNT162b2 mRNA CD4+ CD8+ T lymphocytes Cellular immune response Control COVID-19 COVID-19 vaccine COVID19 evaluated Frequency healthcare worker immune response immunized in vitro induce induced Long mRNA mRNA vaccination pandemic peptides prevention required respond response SARS-CoV2 second dose spike Spread Strategy subjects T lymphocyte T lymphocytes activation to define vaccination Vaccination strategies Vaccine [DOI] 10.3389/fimmu.2022.836495 PMC 바로가기 [Article Type] Article