Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strainsarticle Published on 2017-06-302024-09-01 Journal: Microbial Pathogenesis [Category] 살모넬라증, [키워드] E. coli Pathogens Physiology Probiotics Salmonella enterica Transport proteins [Article Type] article
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa녹농균에 대한 방어를 위해서는 보존된 미토콘드리아 감시 경로가 필요합니다Research Article Published on 2017-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition Bacterial battery Caenorhabditis Caenorhabditis elegans Cell cellular structure conserved Critical cytological damage Defense defense mechanisms described Diseases dysfunction Effect elegan elegans element Ethanol expand exposure to family functions genetics Health heat homeostasis Host host defense human pathogen hypothermia hypoxia Imbalance immune responses include increasingly indicate Infection innate immune response Innate immunity Interaction intestinal kill leads liquid mammals mechanism mechanisms mitigate mitochondrial organelle organism Organisms overlap overlapping oxidative damage P . aeruginosa pathogen Pathogens pathway Physiology Prevent Protein Pseudomonas aeruginosa pyoverdine recognizing Regulation required respond response secreted selective shown Stress stress response Surveillance threat Toxicity transcriptomics unique upregulation variety virulence [DOI] 10.1371/journal.pgen.1006876 PMC 바로가기 [Article Type] Research Article
Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor초파리의 기능성 남성 액세서리 땀샘과 생식력에는 새로운 엑디손 수용체가 필요합니다Research Article Published on 2017-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Nuclear Receptors) analyzed Behavior Biodiversity carried cause cell death cells Critical Depletion dominant negative downstream Drosophila Drosophila melanogaster dying cells Ecdysone examined females Fertility forms Health hormone hormone receptor hormone receptors include independent insect Insects isoform male male fertility male reproductive system males management mechanism of action molecular Nuclear receptors pest control Physiology Protein protein synthesis Proteins receptor receptors regulated Regulation reproduction reproductive reproductive system secretory tissue Seminal fluid sterility tissue transcription factor transcription factors transfer [DOI] 10.1371/journal.pgen.1006788 PMC 바로가기 [Article Type] Research Article
Morphological and physiological features of Arthroderma benhamiae anamorphs isolated in northern Germany북부 독일에서 분리된 Arthroderma benhamiae 아나모프의 형태학적 및 생리학적 특징journal-article Published on 2015-02-012024-08-01 Journal: Mycoses [Category] 백선증, [키워드] dermatophytes Enzymes hyphae morphology Physiology thiamine. [DOI] 10.1111/myc.12280 [Article Type] journal-article
CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with HypomagnesemiaCNNM2 돌연변이는 저마그네슘혈증 환자의 뇌 발달 장애 및 발작을 유발합니다Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied Affect Brain brain development brain malformation brain malformations cation channel cause caused Cell cellular clinical variability CNNM2 Combination cRNA cyclin M2 de novo de novo heterozygous missense mutations demonstrated development Diagnosis disease Effect embryonic explain expressing FIVE gene encoding Genetic genetic cause genetic component genetic disease genetic etiology genetic heterogeneity handling HEK293 cell HEK293 cells heterozygous homeostasis human disease hypomagnesemia identify Impaired IMPROVE in vitro activity increase inheritance injection intellectual disability isoform kidney knockdown loss-of-function Magnesium mammalian Mental mental disability mental retardation Missense mutation mutant mutated Mutation neurodevelopmental impairment neurodevelopmental impairments neurological Neurological diseases occur Pathomechanism Pathomechanisms Patient patients with moderate phenotype Phenotypes physiological Physiology Protein reduced Regulation renal rescued Seizure Seizures shown the disease therapeutic drug Treatment TRPM7 unique wild-type zebrafish [DOI] 10.1371/journal.pgen.1004267 PMC 바로가기 [Article Type] Research Article
Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models새로운 지방세포 및 간세포 일주기 시계 모델에 의해 밝혀진 기간 유전자의 세포 유형별 기능Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipocytes Affect amplitude animals Behavior biochemical Bmal1 Brain Cell cell types cellular circadian clock circadian rhythms CLOCK component Cry1 Cry2 Effect evaluated expected Families feasible fibroblasts function Gene Expression Genes Genetic genomic hepatocyte hepatocytes hypothalamus Impact implication Interaction kinetic knockdown knockout mice lentivirus library Local Luminescence mechanism metabolism microplate reader Model molecular negative feedback negative feedback mechanism neurons novel nuclei Per1 Per2 PER3 Period phenotype Physiology Previous studies regulated reporter reveal Revealed RNA RNA interference small molecule Small molecules tissue specific transcriptional [DOI] 10.1371/journal.pgen.1004244 PMC 바로가기 [Article Type] Research Article
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성Research Article Published on 2012-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation [DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article