Tocilizumab administration is associated with the reduction in biomarkers of coronavirus disease 2019 infection토실리주맙 투여는 코로나바이러스 질병 2019 감염의 바이오마커 감소와 관련이 있습니다Meta-Analysis Published on 2021-03-012022-08-31 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 95% CI administration Analysis article benefit Biomarker Biomarkers C-reactive protein caused confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection D-dimer database death case dimer effective Effectiveness Evidence ferritin immunomodulator increment Infection interleukin interleukin-6 life lymphocyte Lymphocyte count mean difference Meta-analysis number of death Patient Potential treatment procalcitonin PubMed Central random reducing reduction reduction in retrieved searched severity the disease Tocilizumab Treatment [DOI] 10.1002/jmv.26698 PMC 바로가기 [Article Type] Meta-Analysis
Corona viruses: reaching far beyond the common coldArticles Published on 2021-03-012022-10-27 Journal: African Health Sciences [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome Analysis cause Clinical features Cochrane Library common cold Corona coronavirus COVID-19 COVID-19 pandemic Diagnosis disease Epidemics Epidemiology etiology events example finding Frequency Genome gold standard Health Human Intervention invasive literature review long-lasting management mechanical ventilation MERS Middle East Mild MOST outbreak Pandemics patients Potential treatment prevalent Recombination recombination event Respiratory disease Respiratory illness scientist severe disease Severe infection severe respiratory disease strain Strains subsequent supportive care syndrome the SARS-CoV-2 virus undergo understanding upper respiratory infection Vaccine virulent virus viruses was performed worldwide pandemic [DOI] 10.4314/ahs.v21i1.27 PMC 바로가기 [Article Type] Articles
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial경증에서 중등도의 COVID-19 환자의 바이러스 부하에 대한 밤라니비맙 단독 요법 또는 에테세비맙 병용 요법의 효과: 무작위 임상 시험Clinical Trial Published on 2021-02-162022-09-25 Journal: JAMA [Category] MERS, 임상, 진단, 치료법, 치료제, [키워드] 95% CI acute respiratory syndrome age ambulatory patient Analysis antibody bamlanivimab baseline clinical clinical benefit Clinical outcome clinical trial combination therapy combination treatment comparison coronavirus Coronavirus disease 2019 COVID-19 death determine Effect Efficacy End points enrolled etesevimab evaluated evaluation period events Final Hospitalization hypersensitivity reaction Immediate in viral load log measure Mild moderate Moderate COVID-19 monotherapy NCT04427501 neutralizing antibody no significant difference occurred outcome Patient patients with COVID-19 phase 2/3 trial Placebo positive Potential treatment primary end point proportion Randomized receive reduction reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load secondary outcome measure secondary outcome measures Spread statistically significant statistically significant reduction Symptoms tested the placebo group Treatment treatment group Viral load women [DOI] 10.1001/jama.2021.0202 PMC 바로가기 [Article Type] Clinical Trial
Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 PatientsPharmacology Published on 2021-02-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Affect Anti-viral application applied Autoimmune diseases can be used Characteristics children China Clinical findings clinical trial concomitant medications conducted COVID-19 COVID-19 patient Critical development distribution dose dosing recommendation dosing regimen drug-drug interaction extrinsic HCQ Hydroxychloroquine impairment in vitro in vivo experiment inhibitor intrinsic lung lung tissues malaria mechanism metabolism Model optimization organ Pandemics Patient pharmacokinetic physiologically-based pharmacokinetic Population populations Potential treatment pregnant women recommendation reduced Research Specific specific populations subject Support supported Treatment [DOI] 10.3389/fphar.2020.585021 PMC 바로가기 [Article Type] Pharmacology
A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygieneMiscellaneous Published on 2021-02-112022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, MERS, SARS, [키워드] Acid-Oxidizing solution (AOS2020) blocked coronavirus COVID-19 pandemic early stage Efficacy evaluate Guidance HClO highest hygiene Hypochlorous acid (HClO) in vitro indicate initial International intranasal mortality rates nasal National oral mucosa Potential treatment reduce reduced respiratory tract Result safety profile SARS-CoV-2 the disease Tolerability Transmission upper upper respiratory upper respiratory tract Viral load virucidal virus [DOI] 10.1007/s00405-021-06644-5 PMC 바로가기 [Article Type] Miscellaneous
Effectiveness and feasibility of convalescent blood transfusion to reduce COVID-19 fatality ratioMathematics Published on 2021-02-102022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] Analysis appear approach assumption average Blood Complication conditions contribute convalescent convalescent blood transfusion COVID-19 Critical death deaths develop disorders Donor Efficacy Epidemics fatality feasibility feasible implementation Italy Logistic logistic feasibility mathematical Mathematical models outbreak outcome Patient per day performed plasma potential benefit Potential treatment recovered patients reduce reduction reduction of deaths second wave Spread therapeutic option therapy Treatment with COVID-19 [DOI] 10.1098/rsos.202248 PMC 바로가기 [Article Type] Mathematics
SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19SAveRUNNER: 약물 용도 변경을 위한 네트워크 기반 알고리즘 및 COVID-19에 적용Research Article Published on 2021-02-052022-09-02 Journal: PLoS Computational Biology [Category] MERS, 신약개발, 임상, 치료제, [키워드] (hydroxychloroquine Algorithm anti-IL6 anti-TNF applied Arthritis association cardiovascular diseases Chloroquine Clinical practice combination therapy Comorbidity coronavirus Coronavirus infections COVID-19 COVID-19 treatment COVID-19 treatments de novo disease disease-causing downstream drug Drug discovery drug target drugs effective drug effective drugs Efficiency enrichment analysis experiments Focusing gene set enrichment analysis Genetic heparin HIV human coronavirus Hydroxychloroquine in-silico include inhibitors knowledge lAbel lack Lopinavir malaria monoclonal antibodies monoclonal antibody network off-label Potential treatment predict Protein reduce Remdesivir remdesivir) repositioning rheumatoid arthritis rheumatoid arthritis) Ritonavir selected similarity thrombin Tocilizumab treat Vaccine variety worldwide pandemic PMC 바로가기 [Article Type] Research Article
The interplay between emerging human coronavirus infections and autophagy신종 코로나바이러스 감염과 자가포식 사이의 상호작용Review Published on 2021-02-032022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 비임상, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applicability approved autophagic autophagy breath cellular concerning coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection CoV infection COVID-19 drugs targeting Evidence HCoV HCoVs highly pathogenic human coronavirus induce Infection MERS MERS-CoV MHV Middle East Middle East respiratory syndrome Coronavirus mouse hepatitis mouse hepatitis virus outbreak pandemic Potential treatment promote provided Replication respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus stimulate target cell target cells Viral viral propagation [DOI] 10.1080/22221751.2021.1872353 PMC 바로가기 [Article Type] Review
A Comprehensive Summary of the Knowledge on COVID-19 TreatmentReview Published on 2021-02-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] accelerated Chinese Chinese medicine Clinical outcome complementary Comprehensive coronavirus coronavirus disease country COVID-19 COVID-19 epidemic disease drug drug candidate effective Efficacy epidemiologist IMPROVE Intervention knowledge limitations medication pandemic patients with COVID-19 potential mechanisms Potential treatment researcher Strategies TCM Treatment treatment strategy Trial [DOI] 10.14336/AD.2020.1124 PMC 바로가기 [Article Type] Review
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case seriesCOVID-19로 유발된 중증 ARDS 환자 치료를 위한 주산기 조직 유래 중간엽 줄기세포: 사례 시리즈Clinical Trial Published on 2021-01-292022-08-13 Journal: Stem Cell Research & Therapy [Category] 바이오마커, 임상, 진단, [키워드] acute renal and hepatic failure acute respiratory distress syndrome age Allogeneic allogeneic prenatal Alpha ARDS ARDS patients C-reactive protein C-reactive protein (CRP candidate Cardiac arrest Cardiomyopathy case sery cell infusion cell infusions Cell therapy cells chronic lymphocytic leukemia clinical trial CLL CMP Comorbidities Comorbidity Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill develop diabetes diagnosed died discharged distress Dyspnea eight enrolled fatal complication feasibility finding FIVE hepatic failure High dose hospital human umbilical cord MSCs hypertension Hypoxemia ICU ICUs IFN-γ IL-6 IL-6 level IL-6 levels IL-8 IMPROVE Inflammatory biomarker inflammatory biomarkers infusion intensive care unit intensive care units interferon gamma intravenous infusion Large randomized multicenter clinical trials leukemia Leukocytosis lung lymphocyte Lymphocytes mechanical ventilation men mesenchymal stem cell Mesenchymal stem cells Mesenchymal stromal cells MSC MSCs multi-organ failure multicenter one patient outcome Patient patients perinatal tissue Phase 1 PL-MSCs Placenta placental MSC placental MSCs Pneumonia Potential treatment Radiological parameter Radiological parameters Randomized reduce reduced renal reported required respiratory distress Respiratory distress syndrome Safe Sepsis Serious Adverse Event Serious Adverse Events Serum level serum levels Seven severe hypoxemia Significant reduction significant reductions SpO2 stem cell Stem cell therapy supplementary material survivor Survivors syndrome the cell therapeutic potential TNF-α Tolerability Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha UC-MSCs umbilical Umbilical cord women [DOI] 10.1186/s13287-021-02165-4 PMC 바로가기 [Article Type] Clinical Trial