A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex—An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site SurfacePharmacology Published on 2020-12-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 ACE2 binding site antibody antiviral molecule cells complex CR3022 crystal develop Drug discovery form fragment ideal identify in-crystal fragment screening inhibitors New powerful tool PPI inhibitors probe Protein SARC-CoV-2-RBD Screening Site surface target the SARS-CoV-2 virus entry [DOI] 10.3389/fphar.2020.615211 PMC 바로가기 [Article Type] Pharmacology
Modelling interventions to control COVID-19 outbreaks in a refugee campOriginal Research Published on 2020-12-102022-10-28 Journal: BMJ Global Health [Category] COVID-19, MERS, SARS, [키워드] absence applied condition control strategies COVID-19 COVID-19 outbreak COVID-19 pandemic disease Effect effective Epidemics Epidemiology evaluate Evidence explicit Face mask feasible Greece heterogeneous incidence infected individual Infection Intervention Isolation Lesbos Moria other study design Population populations powerful tool Prevent progression public health reduced reducing refugee respiratory infections Result risk Spread spread of COVID-19 the SARS-CoV-2 virus transmission rate Treatment Vaccines [DOI] 10.1136/bmjgh-2020-003727 PMC 바로가기 [Article Type] Original Research
Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes530 Published on 2020-12-082022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis assumption caused Complete coronavirus COVID-19 pandemic Cutoff direct coupling analysis Effect eight epistasis Genome genome sequence GISAID in viral initiative Interaction interactions investigated loci locus microbial Mutation natural selection Nonsynonymous mutations Nsp12 nsp13 nsp14 NSP2 nsp4 ORF3a ORF8 Pathogenesis Pathogens powerful tool public health emergency Recombination Repository reveal SARS-CoV-2 SARS-CoV-2 genome sequence Significance starting point synonymous Vaccine development viral gene viral pathogens Whole-genome sequence [DOI] 10.1073/pnas.2012331117 PMC 바로가기 [Article Type] 530
The use of chest ultrasonography in suspected cases of COVID-19 in the emergency departmentResearch Article Published on 2020-11-302022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] Abstract Accuracy acute respiratory syndrome aspartate AST Chest coronavirus cough COVID-19 diagnosis of COVID-19 diagnostic Dyspnea Fever gold standard identify initial limit lung Lung ultrasound pandemic Patient powerful tool predict RT-PCR SARS-CoV-2 symptomatic patient [DOI] 10.2144/fsoa-2020-0127 PMC 바로가기 [Article Type] Research Article
How COVID-19 is changing rheumatology clinical practice Reviews Published on 2020-11-022022-10-05 Journal: Nature reviews. Rheumatology [Category] SARS, 유전자 메커니즘, 임상, [키워드] Care change Clinical practice COVID-19 COVID-19 pandemic FIVE Government Health hospital limitation limitations pandemic Patient powerful tool Region Research rheumatologist rheumatology Spread the disease Virtual care [DOI] 10.1038/s41584-020-00527-5 [Article Type] Reviews
Clinical Applications of Visual Plasmonic Colorimetric SensingReview Published on 2020-10-302022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, [키워드] Analysis application Bacteria biochemical biological samples Biomarker clinical clinical diagnostics colorimetric sensor coronavirus 2 diagnostics IMPROVE LSPR naked eye nanomaterials nucleic acids Perspective plasmonics point of care powerful tool Proteins provided respiratory SARS-CoV-2 unique variety virus Visual [DOI] 10.3390/s20216214 PMC 바로가기 [Article Type] Review
Investigating the Prevalence of Reactive Online Searching in the COVID-19 Pandemic: Infoveillance StudyOriginal Paper Published on 2020-10-272022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] addressed affected age being Care carried Chloroquine circulation coronavirus correlation Correlation analysis country COVID-19 COVID-19 pandemic COVID-19 testing death determine disease dissemination European fake news Germany global pandemic Google Google Trends Government Health ibuprofen identify imperative infodemiology information Italy limit maintain media misinformation Mortality mortality data objective pandemic Pandemics Panic portal positive correlation powerful tool Premature Public public health authorities resources Result resulting searched selected Spain Spearman Spread Strong temporal dynamics The United States trend United Kingdom Volume [DOI] 10.2196/19791 PMC 바로가기 [Article Type] Original Paper
Cascaded deep learning classifiers for computer-aided diagnosis of COVID-19 and pneumonia diseases in X-ray scansOriginal Article Published on 2020-09-222022-10-31 Journal: Complex & Intelligent Systems [Category] COVID-19, [키워드] Accuracy assist Bacterial binary classifier Biomedical image processing CAD Cascaded classifiers Classifier Coronavirus outbreak COVID-19 COVID-19 infection dataset deep learning Dense diagnose Diagnosis diagnosis of COVID-19 diagnostic procedure disease ENhance evaluated flexible group Health status include infected cases network Neural Patient physician Pneumonia pneumonia images powerful tool Previous studies residual second Support tested Visual X-ray [DOI] 10.1007/s40747-020-00199-4 PMC 바로가기 [Article Type] Original Article
Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assayMethodology Published on 2020-09-102022-10-29 Journal: Journal of Nanobiotechnology [Category] Coronavirus, SARS, [키워드] accelerate analyzed antibody assays Biomarker C-reactive protein C-reactive protein (CRP caused clinically complex Conjugation chemistry consequence Conventional COVID-19 CRP Cytokine storm Diagnosis diagnostics Duplex lateral flow assay event events FIVE Gold nanoparticle handling IL-6 Image processing ImageJ immunoassay include Infection Inflammation Inflammatory information intensities interleukin-6 lateral flow limits medical need Multiplexing Nanoparticles optical pathophysiology POC point-of-care point-of-care diagnostics powerful tool provide quantification Quantitative quantum dots R-package Sandwich immunoassay Sensitivity and specificity Sepsis Shiny app target protein targets test line Treatment was used were used [DOI] 10.1186/s12951-020-00688-1 PMC 바로가기 [Article Type] Methodology
The impact of biosensing in a pandemic outbreak: COVID-19Research article Published on 2020-09-012022-10-05 Journal: Biosensors & bioelectronics [Category] SARS, 바이오마커, [키워드] accelerate approach Biomarkers biosensors country COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 testing CRISPR Critical diagnostic Diseases early stage effective Emerging infectious diseases Germany highlight Infection Isolation Lateral flow assays lower mortality on-site testing outbreak Outbreaks pandemic PCR powerful tool recommendation Serological tests severity South Korea Spread Treatment [DOI] 10.1016/j.bios.2020.112274 [Article Type] Research article