pro-inflammatory cytokine – Page 13 – Communicable Diseases Research

Therapeutic use of specific tumour necrosis factor inhibitors in inflammatory diseases including COVID-19

Review

Published on 2021-08-012022-10-04
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 신약개발,

Profiling of Oral Microbiota and Cytokines in COVID-19 Patients

Microbiology

Published on 2021-07-302022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] 16S rRNA ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 Area AUC automated Bacterial Biomarker clinics consortia Control controls coronavirus COVID-19 COVID-19 patients COVID-19 susceptibility Curve Cytokines demonstrated evidenced group highlighting immunoassays Inflammatory introduced local inflammation machine learning metagenomics microbiota (D064307) mucosa multiplex network analysis oral oral microbiota parameter Patient pilot study predict predominant Prevotella pro-inflammatory cytokine Profiling protease recent reduce Saliva SARS-CoV-2 secreted Sequencing serine 2 serum samples severe coronavirus disease Specy sputum subject subjects Symptoms TMPRSS2 Transcriptome transmembrane Transmission two group Viral RNA
[DOI] 10.3389/fmicb.2021.671813 PMC 바로가기 [Article Type] Microbiology

A systematic review on the effects of Echinacea supplementation on cytokine levels: Is there a role in COVID-19?

사이토카인 수치에 대한 에키네시아 보충제의 효과에 대한 체계적인 검토: COVID-19에 역할이 있습니까?

Articles from the Vaccines, Immune Response, Therapeutic Interventions and COVID-19 Special Issue

Published on 2021-07-292022-09-10
Journal: Metabolism Open [Category] 비임상,

[키워드] Abstract administration AMED anti-inflammatory cytokine appear ARDS, acute respiratory distress syndrome breath caused CCL, C–C motif ligand chemokine changes changes in CINAHL clinical clinical trial clinical trials COVID-19 COVID-19 mortality COVID-19, Coronavirus disease 2019 criteria CSF, Colony-stimulating factor cytokine cytokine level cytokine levels Cytokine release syndrome Cytokine storm Cytokines data extraction database decrease Echinacea Effect Effectiveness Evidence Ex vivo Factor for inclusion GM-CSF, granulocyte-macrophage colony-stimulating factor herbal medicine Highlights identify IFN, interferon IL-10 IL-6 IL-8 IL, interleukin immune modulation immune system in vitro increase in involved management MCP, monocyte chemoattractant protein MIP, macrophage inflammatory protein modulation Novel coronavirus OVID patients with COVID-19 pro-inflammatory cytokine pro-inflammatory cytokines qualitative analysis Research respiratory Respiratory illness risk of bia SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS, Severe acute respiratory syndrome severe COVID-19 suggested systematic review TFN, tumor necrosis factor therapeutic effect therapeutic effects title TNF Treatment Trial unique was used while
[DOI] 10.1016/j.metop.2021.100115 PMC 바로가기 [Article Type] Articles from the Vaccines, Immune Response, Therapeutic Interventions and COVID-19 Special Issue

SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

SARS-COV-2 N 단백질은 타고난 면역을 억제하기 위해 TRIM25- 매개 RIG-I 활성화를 표적으로합니다.

Article

Published on 2021-07-232022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료법,

[키워드] accessory proteins Activation Affect affecting antagonistic characterized clinical picture contributing to counteract COVID-19 Cytokines decrease demonstrated domain ENCODE exacerbated expressed feature host immune system IFN Infection Innate innate immune response Innate immunity Interaction involved Mask mechanism molecular mechanism molecular mechanisms N protein novel SARS-CoV-2 virus occurred Pathways Pattern recognition pattern recognition receptor pro-inflammatory cytokine pro-inflammatory cytokines Protein PRR Recognition reported RIG-I RIG-I activation SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 virus secretion signaling pathways suppresse target the N protein the SARS-CoV-2 TRIM25 Viral viral pathogenesis
[DOI] 10.3390/v13081439 PMC 바로가기 [Article Type] Article

Monocytes and Macrophages in COVID-19

COVID-19의 단핵구 및 대식세포

Review

Published on 2021-07-212022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

[키워드] affected alarmin alveolar macrophage Blood caused cellular characterized clinical manifestation clinical manifestations common cold complex Consequences contagious cough COVID-19 Critical defend Defense detrimental developmental disease dominant dysfunction dysregulated effector cell exacerbating expression Fever Health heterogeneous group HLA-DR homeostasis homeostatic Host host defense hyperinflammation Infection infiltrating Inflammation Inflammatory inflammatory monocyte interferon-stimulated gene invading pathogen invading pathogens knowledge Macrophage macrophage phenotype macrophage phenotypes macrophages mammalian mechanisms mild common cold Moderate COVID-19 monocyte Monocytes mononuclear phagocyte multi-organ failure organism organs pandemic pathogen Pathogens pathological condition pathological conditions patients with moderate phagocytes phenotype plasticity pro-inflammatory cytokine pro-inflammatory cytokine release pulmonary recruited recruitment repair respiratory respiratory distress responsible resulting SARS-CoV-2 scRNA-seq severe disease Severe respiratory distress Symptoms tissue tissue damage Viral viral disease viral infection viral infections while
[DOI] 10.3389/fimmu.2021.720109 PMC 바로가기 [Article Type] Review

The signal pathways and treatment of cytokine storm in COVID-19

Review Article

Published on 2021-07-072022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] 변종, 비임상, 임상,

[키워드] acute respiratory distress affected Antibody-dependent enhancement capillary leak syndrome cells Characteristics characterized clinically COVID-19 COVID-19 pathogenesis current cytokine Cytokine storm death develop disease Disseminated intravascular coagulation downstream dysregulation effective Evidence Fever help IFN-I immune immunopathological immunopathology Infectious disease Infectious diseases Inflammatory diseases inflammatory signaling Intervention involved lymphopenia macrophages monocyte multiorgan failure pandemic pathway Pathways physically poor prognosis pro-inflammatory cytokine proportion receptor reduced Research responsible resulting secreted severe cases Signaling signaling pathway suggested Symptom syndrome tissue Treatment treatment strategy type I interferon
[DOI] 10.1038/s41392-021-00679-0 PMC 바로가기 [Article Type] Review Article

Detection of pre-existing SARS-CoV-2-reactive T cells in unexposed renal transplant patients

노출되지 않은 신장 이식 환자에서 기존 SARS-CoV-2 반응성 T 세포 검출

Original Article

Published on 2021-07-062022-09-10
Journal: Journal of Nephrology [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen-spcific T cells Antiviral Blood donors CD4 CD8 Cohort collected competent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines demonstrated detectable detection expression pattern flow cytometry Frequency healthy healthy blood donors healthy individuals immune Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression magnitude majority Neutralization assay not differ nucleocapsid pandemic Patient patients positive controls pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines produced Protective reactive reactivity recent renal Renal transplantation required respiratory Result SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus supplementary material T cell T cells Th1 cytokine the SARS-CoV-2 were used
[DOI] 10.1007/s40620-021-01092-0 PMC 바로가기 [Article Type] Original Article

Modulation of ACE-2 mRNA by inflammatory cytokines in human thyroid cells: a pilot study

인간 갑상선 세포에서 염증성 사이토카인에 의한 ACE-2 mRNA 조절: 예비 연구

Original Article

Published on 2021-07-052022-09-12
Journal: Endocrine [Category] SARS, 진단,

Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets

아프리카 인구의 COVID-19에 대한 보호: 치료 표적에 대한 면역학, 유전학 및 말라리아 단서

Review

Published on 2021-07-022022-09-11
Journal: Virus research [Category] SARS, 말라리아, 유전자 메커니즘,

[키워드] Africa African alteration antibodies caspase Caspase 12 cellular immunity contribute COVID-19 COVID-19 case Cytokine storm Cytokines death discrepancy drug expression Factor Gene Expression Genetic genetics Glycophorins GYPA help humoral Hyperinflammatory identify Immune cell individual Inflammatory knowledge LAIR-1 lung malaria MAPK mitogen mitogen-activated protein kinase molecular multi-organ failure Multiple NF-kB nuclear pathophysiological mechanism pathophysiological mechanisms Pathways PD-1 pro-inflammatory cytokine protection Protein protein kinase provoke regulate SARS-CoV-2 SARS-CoV-2 seroprevalence severity of COVID-19 stimulate therapeutic target understanding Vaccine
[DOI] 10.1016/j.virusres.2021.198347 PMC 바로가기 [Article Type] Review

Babaodan controls excessive immune responses and may represent a cytokine-targeted agent suitable for COVID-19 treatment

Babaodan은 과도한 면역 반응을 제어하고 COVID-19 치료에 적합한 사이토카인 표적 제제를 나타낼 수 있습니다

Article

Published on 2021-07-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 치료법,

[키워드] Activation adapter anti-cytokine storm anti-inflammatory activity approach Babaodan Bacterial Bacterial infection cellular Chinese contribute Control COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokines demonstrated determine evaluated excessive immune response IL-6 immune responses immunomodulatory in vivo increased survival indicated Inflammation inhibited Macrophage macrophages MAPK MAPK signaling mechanism mice molecular mouse model MYD88 NF-κB occur Occurrence overproduction Pathways Pneumonia pro-inflammatory cytokine pro-inflammatory cytokines protective role Protein recruitment reduction in responsible resulting reveal robust SARS-COV-2 infection Seven severe COVID-19 severely ill COVID-19 patients significantly TCM therapy TLR TLR2 TLR3 TLRs Traditional Chinese medicine transcriptomic treating COVID-19 Treatment TRIF viruses was used
[DOI] 10.1016/j.biopha.2021.111586 PMC 바로가기 [Article Type] Article