HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected HamstersArticle Published on 2022-12-292023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] bioenergetics COVID-19 disease hamster hypoxia proteomics [DOI] 10.3390/ijms24010558 PMC 바로가기
Heritability of Protein and Metabolite Biomarkers Associated with COVID-19 Severity: A Metabolomics and Proteomics AnalysisArticle Published on 2022-12-272023-07-11 Journal: Biomolecules [Category] COVID19(2023년), [키워드] Biomarkers COVID-19 erythrocytes metabolomics proteomics SARS-CoV-2 [DOI] 10.3390/biom13010046 PMC 바로가기
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumoniaArticle Published on 2022-12-132023-06-20 Journal: Immunity [Category] Fulltext, MERS, [키워드] Actin COVID-19 Degradation DNA DNase I histone Inflammation NETs proteomics Sepsis [DOI] 10.1016/j.immuni.2022.11.007 PMC 바로가기
The role of multi-omics in the diagnosis of COVID-19 and the prediction of new therapeutic targetsReview Published on 2022-12-012023-07-09 Journal: Virulence [Category] COVID19(2023년), [키워드] COVID-19 Genomics metabolomics Multi-omics proteomics transcriptomic [DOI] 10.1080/21505594.2022.2092941 PMC 바로가기 [Article Type] Review
Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and futureArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] 진단, [키워드] Antibody assays Antigen Bacterial pathogens change clinical clinical microbiology Clinical practice COVID-19 COVID-19 pandemic Critical Culture Diagnosis diagnostics Diseases evidenced Genomics Gram stain IMPROVE in vitro Infectious disease metabolomics microbial microbial infections Molecular biology MONITOR morphology nucleic acid nucleic acid amplification outcome pathogen detection Patient point of care progression proteomics Revolutionary transcriptomics [DOI] 10.1080/22221751.2022.2125345 PMC 바로가기
The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection [DOI] 10.15252/emmm.202216643 PMC 바로가기
Machine learning algorithms based on proteomic data mining accurately predicting the recurrence of hepatitis B-related hepatocellular carcinomaArticle Published on 2022-11-012023-06-13 Journal: Journal of gastroenterology and hepatology [Category] B형 간염, [키워드] CPTAC database machine learning models proteomics recurrence of hepatocellular carcinoma. [DOI] 10.1111/jgh.15940
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected Analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기