AVIFAVIR for Treatment of Patients With Moderate Coronavirus Disease 2019 (COVID-19): Interim Results of a Phase II/III Multicenter Randomized Clinical Trial중등도 코로나바이러스 질환 2019(COVID-19) 환자 치료를 위한 AVIFAVIR: 2상/3상 다기관 무작위 임상 시험의 중간 결과Clinical Trial Published on 2021-08-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] AVIFAVIR clearance clinical clinical trial COVID-19 COVID-19 patients Favipiravir Interim Ministry of Health Patient phase Registration Result RNA polymerase inhibitor Safe SARS-CoV-2 SARS-CoV-2 viral Treatment treatment of COVID-19 patients viral clearance [DOI] 10.1093/cid/ciaa1176 PMC 바로가기 [Article Type] Clinical Trial
Covid-19 convalescent plasma and SARS-CoV-2 viral variantsCovid-19 회복기 혈장 및 SARS-CoV-2 바이러스 변이체Comment Published on 2021-08-012022-09-11 Journal: Transfusion clinique et biologique : journal de la [Category] SARS, 변종, [키워드] convalescent plasma SARS-CoV-2 viral variant [DOI] 10.1016/j.tracli.2021.05.008 PMC 바로가기 [Article Type] Comment
Locally harvested Covid-19 convalescent plasma could probably help combat the geographically determined SARS-CoV-2 viral variants지역적으로 수확된 Covid-19 회복기 혈장은 아마도 지리적으로 결정된 SARS-CoV-2 바이러스 변이체를 퇴치하는 데 도움이 될 수 있습니다Article Published on 2021-08-012022-09-11 Journal: Transfusion clinique et biologique : journal de la [Category] MERS, SARS, 변종, 진단, [키워드] administer affected Antigen AstraZeneca Bharat Blood donors Blood safety CCP combating convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma COVID-19 patients Donor registry drug effective Efficacy Epitopes help herd immunity Human plasma identify Immunity Inactivated vaccine India individual inherent live vaccine mind multiple epitope multiple epitopes Novel coronavirus Oxford pandemic pandemic status pathogen polyclonal researcher rising Russia SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 virus the vaccine the vaccines United Kingdom Vaccine Vaccine impact variant variants Viral Viral variants [DOI] 10.1016/j.tracli.2021.05.003 PMC 바로가기 [Article Type] Article
Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemicsArticle Published on 2021-07-272022-10-04 Journal: Scientific Reports [Category] 변종, 임상, 진단, [키워드] aAPC activated Antigen antigen presenting cell Applied immunology approach Biotechnology catalytic Cell Clinical course clinical investigation clinically co-stimulatory molecule complexes contribute convalescent COVID-19 patient COVID-19 COVID-19 infection cytokine profile cytomegalovirus Donor effector memory evaluate expand explain generate histocompatibility complex immune immune response immunodominant immunology induced infiltrating leukocyte lymphocyte MHC Mild mononuclear cell Mortality Multisystem organ failure Pandemics Patient PBMC Peripheral blood phenotype Pragmatic prognosis of patient protocol rapid expansion REP robust SARS-CoV-2 SARS-CoV-2 viral T cell T cell receptor therapeutic therapeutic option therapy therapy for COVID-19 Treatment viral pathogen virus [DOI] 10.1038/s41598-021-94654-y PMC 바로가기 [Article Type] Article
Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals혈청 양성 및 혈청 형성 개인에서 SARS-CoV-2 mRNA 백신 투여 동안 체액 면역 반응Research Article Published on 2021-07-262022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] administration antibody antibody level antibody levels Antibody Response Antibody responses Antibody titers approved binding Binding assays BNT162b2 caused comparable coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dose doses Efficacy epitope Epitopes first vaccination global pandemic guide had no high resolution humoral immune responses IgA IgG IgM antibody immune immune response immune responses immunization immunodominant individual Infection mapped Messenger RNA mRNA mRNA vaccine peptide peptides Pfizer-BioNTech protein antigen regimens Result S1 and S2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 viral SARS-CoV-2 virus seronegative seropositive seropositive individual seropositive individuals significantly higher single dose specificity Spike protein subunit supplementary material Support the antibody response the SARS-CoV-2 the SARS-CoV-2 virus USA vaccination Vaccine Viral viral infection while [DOI] 10.1186/s12916-021-02055-9 PMC 바로가기 [Article Type] Research Article
L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virusL-SIGN은 SARS-CoV-2 바이러스에 대한 간 정현파 내피 세포의 수용체입니다.Research Article Published on 2021-07-222022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 authentic SARS-CoV-2 virus Autopsy Blood canonical caused Cell Cell Biology cells clotting factor clotting factors Coagulation Coagulopathy confocal microscopy contribute control cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease dysfunction Endothelial cell endothelial cells entry receptor expressed factor VIII FVIII High-resolution human liver infected cell infected cells Infection L-SIGN liver Lymph node multiple organs N-glycan not express pandemic patients with COVID-19 Protein receptor reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 viral SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe disease SIGN sinusoidal endothelial cell Spike protein the SARS-CoV-2 uninfected Vascular Biology Viral proteins virus [DOI] 10.1172/jci.insight.148999 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2, myocardial injury and inflammation: insights from a large clinical and autopsy studySARS-CoV-2, 심근 손상 및 염증: 대규모 임상 및 부검 연구에서 얻은 통찰력Original Paper Published on 2021-07-192022-09-11 Journal: Clinical Research in Cardiology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] Abstract age analyzed Antigen association Autopsy autopsy study Cardiac autopsy study characterized chronic clinical Clinical data Cohort Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patients Deceased disease Evidence evidence of First wave form histological analysis Hospitalized immunohistochemistry Infection Inflammatory Injury lung Lungs mechanism Myocardial myocardial damage Myocardial inflammation myocardial injury myocarditis Necrosis objective pandemic Patient patients recorded Result RNA RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 viral severe SARS severe SARS-CoV-2 severity of COVID-19 supplementary material the patient tissue Viral viral antigens viral genomes viral persistence [DOI] 10.1007/s00392-021-01910-2 PMC 바로가기 [Article Type] Original Paper
Genomic epidemiological analysis of SARS-CoV-2 household transmissionShort Communications Published on 2021-07-192022-10-28 Journal: Access Microbiology [Category] COVID-19, [키워드] Analysis attack rate B.1 lineage baseline Characteristics circulating Cluster Co-infection Community contributed COVID-19 described diagnosed displaying epidemiological family Family cluster household transmission information Ireland Lineage Local Nasopharyngeal swab notable outbreak Outbreak investigation provide SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral Seven significantly Spread suggested Support Symptom symptomatic case Symptoms Transmission dynamics unlikely Vaccine variant Viral transmission virus WGS whole-genome sequencing Whole-Genome-Sequencing [DOI] 10.1099/acmi.0.000252 PMC 바로가기 [Article Type] Short Communications
Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters중증 급성 호흡기 증후군 코로나바이러스 2는 햄스터의 성숙하고 미성숙한 후각 감각 뉴런을 감염시키고 손상시킵니다Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] Acute inflammation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affecting Antigen Apoptosis Cell cells chemokine ciliated contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Cytokines damage destruction develop epithelial cells hamster hamsters highest immature Infection Inflammatory inflammatory cell inflammatory cell infiltration Inflammatory cytokine Inflammatory cytokines intranasal Invasion investigated less location Loss of Smell marker nasal nasal turbinate Neuron neuronal function olfactory olfactory bulb olfactory bulbs olfactory dysfunction Olfactory epithelium olfactory neuron olfactory neuron. Pathogenesis patients peaked Postinfection proinflammatory Proinflammatory cytokine proportion Protein reported respiratory respiratory epithelial cells respiratory tract infection response resulting SARS-CoV-2 SARS-CoV-2 viral Sensory sensory neuron severe acute respiratory syndrome Coronavirus Symptom tissues unique Viral load β-tubulin [DOI] 10.1093/cid/ciaa995 PMC 바로가기 [Article Type] Article
Intranasal gene therapy to prevent infection by SARS-CoV-2 variantsSARS-CoV-2 변이체에 의한 감염을 예방하기 위한 비강내 유전자 요법Research Article Published on 2021-07-152022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] ACE2 administration affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals Antiviral approach bind binding caused Cell combating coronavirus Coronaviruses countermeasure CoV COVID-19 COVID-19 pandemic CoVs demonstrated effective Efficacy evade expression Gene therapy human ACE2 humans immune response improvement infecting Infection Intervention intranasal intranasally less long-lasting monoclonal antibodies monoclonal antibody mouse model nasal Nasal spray neutralize Pandemics pathogenicity pathologic consequence Patient Population pre-existing immunity Prevent Prophylaxis Protein proximal receptor reduce respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral secrete significantly Spread tested the patient therapeutic Transmissibility unlikely vaccination Vaccinations Vaccine Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations viral particle Viral particles Viral vector virus Vulnerable populations zoonosis [DOI] 10.1371/journal.ppat.1009544 PMC 바로가기 [Article Type] Research Article